Apparent production of 2 types of antibdoies by a single cell     

J G Michael  R Marcus 《Science (New York, N.Y.)》1968,159(820):1247-1249

Immunization of mice with bacterial, sheep red cells coated with antigen resulted in apparent production of antibody-forming plaques with specificities for both hemolysis and bactericidal activity. The secondary response for production of these bifunctional types of plaques could be induced by red blood cells or bacteria alone. A significant mutual suppression of immune response between the two immunizing agents was observed.  相似文献   

Snares Awaiting the American Scientist     

Marcus JK 《Science (New York, N.Y.)》1953,117(3045):507-509

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Speeding up the EPA review process     

Peacock M 《Science (New York, N.Y.)》2007,316(5821):53

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A proposal for a Decade of the Mind initiative     

Albus JS  Bekey GA  Holland JH  Kanwisher NG  Krichmar JL  Mishkin M  Modha DS  Raichle ME  Shepherd GM  Tononi G 《Science (New York, N.Y.)》2007,317(5843):1321

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NIOSH and the CDC reorganization     

Key MM  Robbins A  Millar JD  Rosenstock L 《Science (New York, N.Y.)》2004,305(5684):607

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Martian craters: number density     

Marcus AH 《Science (New York, N.Y.)》1968,160(3834):1333-1335

The incremental frequency distribution of Martian crater diameters larger than 20 to 30 kilometers follows an inverse-square law, with density equal to that of craters on the lunar continents. This finding accords with the prediction that lunar continents and the Martian surface carry an equilibrium density (saturation) of craters originating in meteoroidal impact. Therefore crater statistics alone cannot be used for estimation of the age of the Martian surface.  相似文献   

Statement on scientific publication and security     

Atlas R  Campbell P  Cozzarelli NR  Curfman G  Enquist L  Fink G  Flanagin A  Fletcher J  George E  Hammes G  Heyman D  Inglesby T  Kaplan S  Kennedy D  Krug J  Levinson R  Marcus E  Metzger H  Morse SS  O'Brien A  Onderdonk A  Poste G  Renault B  Rich R  Rosengard A  Salzburg S  Scanlan M  Shenk T  Tabor H  Varmus H  Wimmer E  Yamamoto K;Journal Editors  Authors Group 《Science (New York, N.Y.)》2003,299(5610):1149

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Genetic structure of human populations   总被引：1，自引：0，他引：1  

Rosenberg NA  Pritchard JK  Weber JL  Cann HM  Kidd KK  Zhivotovsky LA  Feldman MW 《Science (New York, N.Y.)》2002,298(5602):2381-2385

We studied human population structure using genotypes at 377 autosomal microsatellite loci in 1056 individuals from 52 populations. Within-population differences among individuals account for 93 to 95% of genetic variation; differences among major groups constitute only 3 to 5%. Nevertheless, without using prior information about the origins of individuals, we identified six main genetic clusters, five of which correspond to major geographic regions, and subclusters that often correspond to individual populations. General agreement of genetic and predefined populations suggests that self-reported ancestry can facilitate assessments of epidemiological risks but does not obviate the need to use genetic information in genetic association studies.  相似文献   

Uncertainty and adaptive management for biodiversity conservation   总被引：2，自引：0，他引：2  

David A. Keith  Tara G. Martin  Eve McDonald-Madden  Carl Walters 《Biological conservation》2011,(4):1175-1178

Adaptive management of natural resources is widely supported, but in biodiversity conservation there have been few practical applications of the approach in its entirety. Some of the contributions to this special publication examine progress in the implementation of adaptive approaches into conservation policy, while others explore novel theoretical and modeling approaches that seek to accommodate the complexities of real-world applications. Several of the papers address the treatment of uncertainty in adaptive management through innovative approaches to experimentation and monitoring, use and characterisation of expert knowledge and reconciliation of differences of opinion about parameters or systems. Drawing on these contributions, we discuss the major impediments to implementing adaptive management, why adaptive management has been slow to be implemented and how this can be redressed.  相似文献   

Pterocarpan profiles for soybean leaves at different growth stages and investigation of their glycosidase inhibitions     

Yuk HJ  Curtis-Long MJ  Ryu HW  Jang KC  Seo WD  Kim JY  Kang KY  Park KH 《Journal of agricultural and food chemistry》2011,59(23):12683-12690

Soybean leaves are eaten as seasonal edible greens in Korea. Analysis of the ethyl acetate extract of these leaves showed that it exhibited potent and selective neuraminidase inhibition, which began at the R3 stage and peaked at R7. Ten pterocarpans, including the new 6a-hydroxypterocarpan 10, were isolated from soybean leaves and their inhibition activities tested against a range of glycosidases. The relationship between structure and enzyme inhibition was investigated: 6a-hydroxypterocarpans exhibited much higher inhibition against neuraminidase (IC(50) = 2.4-89.4 μM) than α-glucosidase (IC(50) = 90.4-?>100 μM). Glyceollin VII (7) displayed 40-fold greater activity (IC(50) = 2.4 μM) against neuraminidase than α-glucosidase (IC(50) = 90.4 μM). On the other hand, coumestanes (1-3) were good α-glucosidase inhibitors (IC(50) = 6.0-42.6 μM). In kinetic analysis, the most potent neuraminidase inhibitors (5-10) were noncompetitive. HPLC analysis indicated that most pterocarpan synthesis began from the R3 stage, and a rapid change of pterocarpan concentrations was observed between the R4 and R7 stages.  相似文献