Melanopsin is required for non-image-forming photic responses in blind mice     

Panda S  Provencio I  Tu DC  Pires SS  Rollag MD  Castrucci AM  Pletcher MT  Sato TK  Wiltshire T  Andahazy M  Kay SA  Van Gelder RN  Hogenesch JB 《Science (New York, N.Y.)》2003,301(5632):525-527

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University-industry interaction     

Cody GD  Compton WD  Roy R 《Science (New York, N.Y.)》1973,181(4102):800

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Involvement of mammalian Mus81 in genome integrity and tumor suppression     

McPherson JP  Lemmers B  Chahwan R  Pamidi A  Migon E  Matysiak-Zablocki E  Moynahan ME  Essers J  Hanada K  Poonepalli A  Sanchez-Sweatman O  Khokha R  Kanaar R  Jasin M  Hande MP  Hakem R 《Science (New York, N.Y.)》2004,304(5678):1822-1826

Mus81-Eme1 endonuclease has been implicated in the rescue of stalled replication forks and the resolution of meiotic recombination intermediates in yeast. We used gene targeting to study the physiological requirements of Mus81 in mammals. Mus81-/- mice are viable and fertile, which indicates that mammalian Mus81 is not essential for recombination processes associated with meiosis. Mus81-deficient mice and cells were hypersensitive to the DNA cross-linking agent mitomycin C but not to gamma-irradiation. Remarkably, both homozygous Mus81-/- and heterozygous Mus81+/- mice exhibited a similar susceptibility to spontaneous chromosomal damage and a profound and equivalent predisposition to lymphomas and other cancers. These studies demonstrate a critical role for the proper biallelic expression of the mammalian Mus81 in the maintenance of genomic integrity and tumor suppression.  相似文献   

Chondrite barium, neodymium, and samarium isotopic heterogeneity and early Earth differentiation     

Carlson RW  Boyet M  Horan M 《Science (New York, N.Y.)》2007,316(5828):1175-1178

Isotopic variability in barium, neodymium, and samarium in carbonaceous chondrites reflects the distinct stellar nucleosynthetic contributions to the early solar system. We used 148Nd/144Nd to correct for the observed s-process deficiency, which produced a chondrite 146Sm-142Nd isochron consistent with previous estimates of the initial solar system abundance of 146Sm and a 142Nd/144Nd at average chondrite Sm/Nd ratio that is lower than that measured in terrestrial rocks by 21 +/- 3 parts per million. This result strengthens the conclusion that the deficiency in 142Nd in chondrites relative to terrestrial rocks reflects 146Sm decayand earlyplanetary differentiation processes.  相似文献   

Inflammatory arthritis. How immune system gangs up on joints     

Beckman M 《Science (New York, N.Y.)》2002,297(5587):1626-1627

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Distal conformation of the thyroid hormone 3,5,3'-triiodo-L-thyronine     

V Cody  W L Duax 《Science (New York, N.Y.)》1973,181(101):757-758

In the crystal structure of the thyroid hormone, 3,5,3'-triiodo-L-thyronine, the 3' iodine is observed in the distal position, away from the alaninebearing ring of the thyroid hormone. This result had been anticipated from stereochemical and biological activity studies. However, previous observations of structures in which the 3' iodine was proximal had cast some doubt on the stability of the 3' distal conformation. This observation suggests that the relative energies of the two conformers is similar and that perhaps the barrier to rotation is not as great as previously supposed since both the distal and proximal conformers have now been observed in the solid state.  相似文献   

Statement on scientific publication and security     

Atlas R  Campbell P  Cozzarelli NR  Curfman G  Enquist L  Fink G  Flanagin A  Fletcher J  George E  Hammes G  Heyman D  Inglesby T  Kaplan S  Kennedy D  Krug J  Levinson R  Marcus E  Metzger H  Morse SS  O'Brien A  Onderdonk A  Poste G  Renault B  Rich R  Rosengard A  Salzburg S  Scanlan M  Shenk T  Tabor H  Varmus H  Wimmer E  Yamamoto K;Journal Editors  Authors Group 《Science (New York, N.Y.)》2003,299(5610):1149

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Pheromone reception. When in doubt, mice mate rather than hate     

Beckman M 《Science (New York, N.Y.)》2002,295(5556):782

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Soft-tissue vessels and cellular preservation in Tyrannosaurus rex     

Schweitzer MH  Wittmeyer JL  Horner JR  Toporski JK 《Science (New York, N.Y.)》2005,307(5717):1952-1955

Soft tissues are preserved within hindlimb elements of Tyrannosaurus rex (Museum of the Rockies specimen 1125). Removal of the mineral phase reveals transparent, flexible, hollow blood vessels containing small round microstructures that can be expressed from the vessels into solution. Some regions of the demineralized bone matrix are highly fibrous, and the matrix possesses elasticity and resilience. Three populations of microstructures have cell-like morphology. Thus, some dinosaurian soft tissues may retain some of their original flexibility, elasticity, and resilience.  相似文献   

Genetics. Poultry genetic resources--operation rescue needed     

Fulton JE  Delany ME 《Science (New York, N.Y.)》2003,300(5626):1667-1668

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