An enzootic of calf pneumonia associated with Mycoplasma bovirhinis     

T Shimizu  D Nosaka  N Nakamura 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1973,35(6):535-537

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Histopathology of spermatocele of fowl (author's transl)]     

M Nakamura  M Inoue 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1979,41(1):41-51

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Effect of parthenocarpy,peeling and fruit age on the changes in volume and specific gravity of cucumber fruits during storage at 20°C     

R. Sakiyama  Yuzo Nakamura  S. Nakamura 《Scientia Horticulturae》1978,8(3):229-236

Either parthenocarpically grown, peeled or at any stage of picking, cucumber fruits showed a tendency to increase in volume and decrease in specific gravity while they were stored under unsaturated vapour pressure at 20°C. The amount of change varied according to the treatment.Recovery from a flaccid appearance occurred in all fruit except very young ones. In those fruits the incipient recovery from wilting, an increase in volume and a decrease in specific gravity, coincided.Parthenocarpic fruits showed an increase in volume at almost the same rate in any transverse quarter of a fruit, in contrast to the pollinated ones in which the most distal quarter enlarged more than the other parts. Pithy appearance of the fruit wall was evenly distributed through a parthenocarpic fruit to a moderate degree, but at the proximal half of a pollinated one it was severe.  相似文献   

Epidemiology, pathology, and immunohistochemistry of layer hens naturally affected with H5N1 highly pathogenic avian influenza in Japan     

Nakatani H  Nakamura K  Yamamoto Y  Yamada M  Yamamoto Y 《Avian diseases》2005,49(3):436-441

Epidemiology, pathology, and immunohistochemistry were investigated in layer hens affected with H5N1 highly pathogenic avian influenza, which occurred for the first time in 79 years in Japan. The farm, which had a total of 34,640 chickens, experienced up to 43.3% mortality before the chickens were depopulated. Clinically, the affected chickens exhibited mortality without apparent clinical signs. Histologically, hepatocytic necrosis; necrosis of ellipsoids and follicles with fibrin in the spleen; necrosis with glial nodules in the brain stem, cerebrum, and cerebellum; necrosis of acinar cells in the pancreas; and necrosis of lymphoid tissues in intestinal lamina propria were seen. Occasionally, mild bronchiolitis, degeneration of smooth muscle fibers in the cecum, and mild tubulonephrosis were noted. Immunohistochemically, influenza virus antigens were detected often in the liver and spleen, heart, intestine, gizzard, proventriculus, and oviduct. In addition, antigens were seen also in the brain, kidney, pancreas, and ovary, but seldom in the lung and trachea. Virus antigen was mainly detected in the capillary endothelium and parenchymal cells. This suggests that virus excretion from the respiratory tract was not as prevalent as that from the digestive tract in the present cases.  相似文献   

Inhibitory effect of several fluoroquinolones on hepatic microsomal cytochrome P-450 1A activities in dogs     

Regmi NL  Abd El-Aty AM  Kuroha M  Nakamura M  Shimoda M 《Journal of veterinary pharmacology and therapeutics》2005,28(6):553-557

We examined inhibitory effects of ofloxacin (OFX), orbifloxacin (OBFX), ciprofloxacin (CFX), enrofloxacin (EFX) and norfloxacin (NFX) on cytochrome P-450 1A (CYP1A) activities using hepatic microsomes from four beagle dogs. Ethoxyresorufin O-de-ethylation was referred as CYP1A activities. All the fluoroquinolones inhibited the reaction in a noncompetitive manner. The determined inhibitory constants were the followings; 10.1 +/- 3.8 mM for OFX, 6.43 +/- 2.01 mM for OBFX, 0.726 +/- 0.134 mM for CFX, 4.06 +/- 1.19 mM for EFX and 4.75 +/- 1.63 mM for NFX respectively. As these values are >100-fold of plasma concentrations after a clinical single dose of the fluoroquinolones, it is suggested that the inhibitory effect on CYP1A activities is not so high to elicit drug-drug interaction with CYP1A substrates, when these fluoroquinolones are co-administered. Mechanism based inhibition was also examined in this study. Of the five fluoroquinolones examined, OFX, OBFX and CFX had this inhibition manner. As this inhibition is irreversible, inhibitory effects of the three fluoroquinolones may accumulate, when they are repeatedly administered. Therefore, OFX, OBFX and CFX may result in substantial drug-drug interaction with a CYP1A substrate even in clinical states. As EFX is metabolized to CFX in the body, it may also have the same possibility.  相似文献   

N-acetylglucosaminyltransferase I activity of bovine oviduct epithelial cells: stimulation by luteinizing hormone, vascular endothelial growth factor and tumor necrosis factor alpha     

Nozaki H  Wijayagunawardane MP  Kodituwakku SP  Yoshida T  Nakamura T  Arai I  Urashima T  Miyamoto A 《The Journal of reproduction and development》2005,51(2):229-234

N-acetylglucosaminyltransferase I (GnT I; EC 2.4.1.101), which catalyzes the first step in the conversion of oligomannose to complex or hybrid N-glycans of glycoproteins, was found in media cultured with bovine oviduct epithelial cells (BOEC) obtained from non-pregnant cows during the follicular phase. Combined treatment with specific hormones increased GnT I release from BOEC. Luteinizing hormone (LH; 10 ng/ml) alone slightly, but together with 17beta-estradiol (E2; 1 ng/ml), synergistically increased GnT I activity. Vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF) alpha, which have been shown to have their highest activities in the bovine oviduct during the periovulatory period, also increased in GnT I activity. This study provides the first evidence of an increase of GnT I release from BOEC in vitro, and shows that endocrine as well as local factors such as LH, VEGF and TNFalpha increase this activity. The results suggest that GnT I activity in the bovine oviduct may contribute to the induction of glycosylation and thereby contributing to the provision of the optimal microenvironment for fertilization and early development of the embryos.  相似文献   

Effects of heat stress on the redox status in the oviduct and early embryonic development in mice     

Matsuzuka T  Ozawa M  Nakamura A  Ushitani A  Hirabayashi M  Kanai Y 《The Journal of reproduction and development》2005,51(2):281-287

This study examined the association between redox status in the oviduct and early embryonic death in heat-stressed mice. In Experiment 1, non-pregnant mice were heat-stressed at 35 C with 60% relative humidity for 12, 24, or 36 h, and the maternal redox status was verified by measuring the levels of reactive oxygen species (ROS) and free radical scavenging activity (FRSA) in the oviduct, and thiobarbituric acid reactive substances (TBARS) and glutathione peroxidase (GSH-Px) activity in the liver. In Experiment 2, zygotes were collected from mice heat-stressed for 12 h on the day of pregnancy, and their developmental abilities were assessed in vitro, along with the intensity of DNA damage at the 2-cell stage. The TBARS value and GSH-Px activity in the liver, and ROS level in the oviduct were significantly higher in heat-stressed mice, and this increase appeared to depend on the duration of the heat stress. Maternal heat stress significantly reduced the percentage of zygotes that developed to the morula and blastocyst and the total cell number in the blastocyst. In addition, DNA damage at the 2-cell stage was significantly higher in maternally heat-stressed embryos. These results suggest that heat stress induces systemic changes in redox status in the maternal body, and the resultant increase in oxidative stress in the oviduct is possibly involved in heat stress-induced early embryonic death .  相似文献   

Clinical application of computed tomography for the diagnosis of feline hepatic lipidosis     

Nakamura M  Chen HM  Momoi Y  Iwasaki T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2005,67(11):1163-1165

The usefulness of computed tomography (CT) for the diagnosis of feline hepatic lipidosis (FHL) was evaluated. Liver CT number was 54.7+/-5.6 HU (mean+/-SD) in 26 healthy cats. We fast 6 healthy cats for 72 hr to induced FHL experimentally and the cats were assessed by CT and serum biochemical analysis. Liver CT number of the six cats was 53.8+/-3.0 HU before fasting, 46.8+/-2.4 HU after fasting, and 50.2+/-3.6 HU two weeks after restarted feeding. The decreased CT number was associated with the elevation of serum non-esterified fatty acid (NEFA) and beta-hydroxybutyrate levels. These results indicate that measurement of CT number of the liver is an effective procedure for the diagnosis of FHL.  相似文献   

Volume and specific gravity of cucumber fruits as affected by moisture condition after harvest     

R. Sakiyama  S. Nakamura 《Scientia Horticulturae》1980,12(2):117-124

When cucumber fruits were stored at temperatures of 10, 20 and 30°C, in conditions that were so wet that they were able to absorb water freely through the skin, they maintained a constant specific gravity which was a hhigh as it had been at the time of picking, with a hyperbolic increase in volume. After removal to unsaturated vapour conditions at 20°C, their volume and specific gravity changed in a similar way to these of fruit which had not been in wet storage. Storage in humid conditions at 10°C resulted in almost constant specific gravity and volume, but storage at 20 or 30°C produced a gradual increase in volume as well as a decrease in specific gravity of fruits, in spite of the fresh weight showing little change. After removal of these fruits to unsaturated vapour conditions, the volume and specific gravity changed at a much faster rate with their specific rates having a peak. The shorter the humid storage, the higher the peak. The decrease in the specific gravity of picked cucumber fruits was discussed in relation to the presence of water stress.  相似文献   

Epidemiological study on periodontal diseases and some other dental disorders in dogs     

H Isogai  E Isogai  H Okamoto  H Shirakawa  F Nakamura  T Matsumoto  T Watanabe  H Miura  Y Aoi  W Kagota 《Nippon juigaku zasshi. The Japanese journal of veterinary science》1989,51(6):1151-1162

The prevalence of dental disorders in dogs was studied by applying index systems for human with some modifications. A total of 251 mongrel dogs including 143 stray dogs kept in the Animal Protection Offices in Tokyo and Hokkaido and 108 pet dogs visiting veterinary clinicians in Chiba Prefecture and Hokkaido were used. Periodontitis was prevalent among these dogs regardless of their sources and its incidence was increased with age. The lesion was more severe and more frequent in the premolar and molar regions than in the maxillary and mandibular incisor regions. Missing of teeth was observed at a high and increasing incidence with age. The tooth most commonly lost was the first premolar, followed by the other premolars and molars, where severe periodontitis was frequently found. Calculus was seen on many teeth, and aging agravated its prevalence and severity. Dental caries was observed in stray dogs, but neither to a serious degree nor at a significant level. These findings emphasize the necessity of dental hygiene, proper dental care and continuous periodical survey for dogs.  相似文献