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排序方式： 共有2135条查询结果，搜索用时 15 毫秒
971.
Baumeister W Bachmair A Chau V Cohen R Coffino P Demartino G Deshaies R Dohmen J Emr S Finley D Hampton R Hill C Hochstrasser M Huber R Jackson P Jentsch S Johnson E Kwon YT Pagano M Pickart C Rechsteiner M Scheffner M Sommer T Tansey W Tyers M Vierstra R Weissman A Wilkinson KD Wolf D 《Science (New York, N.Y.)》2004,306(5700):1290-1292
972.
George S Rochford JJ Wolfrum C Gray SL Schinner S Wilson JC Soos MA Murgatroyd PR Williams RM Acerini CL Dunger DB Barford D Umpleby AM Wareham NJ Davies HA Schafer AJ Stoffel M O'Rahilly S Barroso I 《Science (New York, N.Y.)》2004,304(5675):1325-1328
Inherited defects in signaling pathways downstream of the insulin receptor have long been suggested to contribute to human type 2 diabetes mellitus. Here we describe a mutation in the gene encoding the protein kinase AKT2/PKBbeta in a family that shows autosomal dominant inheritance of severe insulin resistance and diabetes mellitus. Expression of the mutant kinase in cultured cells disrupted insulin signaling to metabolic end points and inhibited the function of coexpressed, wild-type AKT. These findings demonstrate the central importance of AKT signaling to insulin sensitivity in humans. 相似文献
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Petra Sim
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Ron Lowe Valentina Granziera Alessio Pierini Filippo Torrigiani George Lubas 《Veterinary and comparative oncology》2020,18(3):428-432
Non‐tonsillar squamous cell carcinoma (ntSCC) is a common and locally aggressive oral tumour in dogs. The treatments of choice are currently surgery and radiotherapy. Electrochemotherapy (ECT) is a local ablative anti‐tumour technique using electric pulses to enhance the intracellular diffusion of cytotoxic drugs. The aim was to retrospectively evaluate the outcome of patients with oral ntSCC treated with ECT. Twelve dogs with ntSCC were retrospectively enrolled. ECT was combined with IV bleomycin (15 000 UI/m2) alone in 11 cases and post‐surgery in 1. Parameters considered were: tumour site and size, electroporation parameters, response rate (complete remission [CR], partial remission [PR]), median survival time (MST), recurrence rate (RR), median disease‐free interval (DFI) and treatment toxicity (6‐point scale). Median tumour size was 1.65 cm (range 0.3‐8.0 cm) and the response rate was 90.9% (10/11; 8 CR and 2 PR). Two dogs underwent a second ECT. MST for dogs dead with tumour (n = 2) was 110 days and for dogs dead without tumour (n = 3) was 831 days. Among five surviving dogs, one experienced tumour recurrence and four were in CR. Results from two dogs were analysed separately. Overall RR was 27.3%. DFI and MST for dogs with recurrence were 50 and 115 days, respectively. Treatment toxicity was very low. We noticed that all dogs with tumours smaller than 1‐2 cm achieved CR without recurrence suggesting a favourable prognosis when using ECT. ECT for canine ntSCC could be considered a valid treatment option especially for smaller tumours, but a larger caseload would be needed to confirm this statement. 相似文献
979.
Eberhart-Phillips D Haeussler PJ Freymueller JT Frankel AD Rubin CM Craw P Ratchkovski NA Anderson G Carver GA Crone AJ Dawson TE Fletcher H Hansen R Harp EL Harris RA Hill DP Hreinsdóttir S Jibson RW Jones LM Kayen R Keefer DK Larsen CF Moran SC Personius SF Plafker G Sherrod B Sieh K Sitar N Wallace WK 《Science (New York, N.Y.)》2003,300(5622):1113-1118
The MW (moment magnitude) 7.9 Denali fault earthquake on 3 November 2002 was associated with 340 kilometers of surface rupture and was the largest strike-slip earthquake in North America in almost 150 years. It illuminates earthquake mechanics and hazards of large strike-slip faults. It began with thrusting on the previously unrecognized Susitna Glacier fault, continued with right-slip on the Denali fault, then took a right step and continued with right-slip on the Totschunda fault. There is good correlation between geologically observed and geophysically inferred moment release. The earthquake produced unusually strong distal effects in the rupture propagation direction, including triggered seismicity. 相似文献
980.
An object spinning at the surface of a liquid creates a chiral vortex. If the spinning object is itself chiral, its shape modifies the characteristics of the vortex; interactions between that vortex and other vortices then depend on the chirality of the objects that produce them. This paper describes the aggregation of millimeter-sized, chiral magnetized plates floating at a liquid-air interface and rotating under the influence of a rotating external magnetic field. This external field confines all the plates at densities that cause the vortices they generate to interact strongly. For one set of plates investigated, plates of one chirality attract one another, and plates of the other chirality repel other plates of both chiralities. 相似文献