Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis   总被引：1，自引：0，他引：1  

Ricci R  Sumara G  Sumara I  Rozenberg I  Kurrer M  Akhmedov A  Hersberger M  Eriksson U  Eberli FR  Becher B  Borén J  Chen M  Cybulsky MI  Moore KJ  Freeman MW  Wagner EF  Matter CM  Lüscher TF 《Science (New York, N.Y.)》2004,306(5701):1558-1561

In vitro studies suggest a role for c-Jun N-terminal kinases (JNKs) in proatherogenic cellular processes. We show that atherosclerosis-prone ApoE-/- mice simultaneously lacking JNK2 (ApoE-/- JNK2-/- mice), but not ApoE-/- JNK1-/- mice, developed less atherosclerosis than do ApoE-/- mice. Pharmacological inhibition of JNK activity efficiently reduced plaque formation. Macrophages lacking JNK2 displayed suppressed foam cell formation caused by defective uptake and degradation of modified lipoproteins and showed increased amounts of the modified lipoprotein-binding and -internalizing scavenger receptor A (SR-A), whose phosphorylation was markedly decreased. Macrophage-restricted deletion of JNK2 was sufficient to decrease atherogenesis. Thus, JNK2-dependent phosphorylation of SR-A promotes uptake of lipids in macrophages, thereby regulating foam cell formation, a critical step in atherogenesis.  相似文献   

Results of the long-term field experiment IOSDV Rakičan at the beginning of the 21st century     

Anton Tajnšek  Zoran Čergan  Barbara Čeh 《Archives of Agronomy and Soil Science》2013,59(8):1109-1119

This article presents the results of a long-term field experiment at Raki?an (Eastern Slovenia). Between 1993 and 2010, the temperature increased at a rate of 0.0288°C a^?1, while average annual precipitation did not change, but showed great variation from year to year. In years with a higher average annual temperature, higher crop yields were achieved. Higher amounts of precipitation had a positive impact on yield at higher mineral nitrogen (N) rates, but a negative impact on yield in treatments with no mineral N. In systems with farmyard manure (FYM) and straw incorporation, maize yields increased in accordance with the increase in mineral N. Winter wheat yields increased with increasing mineral N to the N1 mineral N application rate with FYM application, and N2 with straw incorporation. Yields of winter barley increased in accordance with increasing mineral N until the highest N application rate (N3) with FYM application, and until N2 with straw incorporation. With regard to environmental compliance requirements for N and C balances and the crop yields, in FYM the most appropriate rate of fertilization is N1, and with straw incorporation the most appropriate rate is N1 to N2.  相似文献   

Book review     

Ida A. Leone  Myron Solberg Ph.D. 《American Journal of Potato Research》1970,47(8):318-319

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Proteomics as a methodology for the characterization of potential new markers of stress elicited by strenuous exercise in sporting dogs – a preliminary study     

Vučinić Srđan  Vrbanac Zoran  Belić Maja  Šmit Iva  Stanin Damir  Horvatić Anita 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2013,42(2):123-124

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Effect of temperature on the biology of Acyrthosiphon gossypii Mordvilko (Homoptera: Aphididae) on cotton   总被引：2，自引：0，他引：2  

Gui-Zhen Gao  Lynda E. Perkins  Myron P. Zalucki  Zhao-Zhi Lu  Ji-Hong Ma 《Journal of pest science》2013,86(2):167-172

Acyrthosiphon gossypii is a widespread, major pest of cotton in central Asia. Effects of specific temperatures on A. gossypii development and survival are unknown and would be useful in helping interpret population dynamics and devising management tactics for this pest. In this paper, the effect of temperature on the life table of A. gossypii reared on cotton was evaluated under laboratory conditions using temperatures of 18, 21, 24, 27, and 30 °C. The developmental rate of immatures increased exponentially from 18 to an optimum around 27 °C and then declined. The estimated lower developmental threshold was 8.0 °C, and 107.5 degree days were required for development from the first instar to adult. The percentage survival of immature stages varied from 81 to 91 % within the range of 18-27 °C. Survival declined to 27 % at 30 °C. The average longevity of adult females was 15.7, 11.7, 8.2, 5.2, and 2.8 days, and the average number of offspring produced per female was 46, 38, 20, 14, and 0, at temperatures of 18, 21, 24, 27, and 30 °C, respectively. From 21-27 °C, the intrinsic rate of increase of A. gossypii was significantly higher than at 18 °C, indicating that 21–27 °C was within the optimal range for the growth of A. gossypii, and that 30 °C constant is beyond the upper limit for reproduction. The observations will form the basis of a forecasting system and could account for the decline of the species on cotton in central Asia as well as other regions during hot summer months.  相似文献   

Impacts of climate change on the complex life cycles of fish     

Pierre Petitgas  Adriaan D. Rijnsdorp  Mark Dickey‐Collas  Georg H. Engelhard  Myron A. Peck  John K. Pinnegar  Ken Drinkwater  Martin Huret  Richard D. M. Nash 《Fisheries Oceanography》2013,22(2):121-139

To anticipate the response of fish populations to climate change, we developed a framework that integrates requirements in all life stages to assess impacts across the entire life cycle. The framework was applied on plaice (Pleuronectes platessa) and Atlantic herring (Clupea harengus) in the North Sea, Atlantic cod (Gadus morhua) in the Norwegian/Barents Seas and European anchovy (Engraulis encrasicolus) in the Bay of Biscay. In each case study, we reviewed habitats required by each life stage, habitat availability, and connectivity between habitats. We then explored how these could be altered by climate change. We documented environmental processes impacting habitat availability and connectivity, providing an integrated view at the population level and in a spatial context of potential climate impacts. A key result was that climate‐driven changes in larval dispersion seem to be the major unknown. Our summary suggested that species with specific habitat requirements for spawning (herring) or nursery grounds (plaice) display bottlenecks in their life cycle. Among the species examined, anchovy could cope best with environmental variability. Plaice was considered to be least resilient to climate‐driven changes due to its strict connectivity between spawning and nursery grounds. For plaice in the North Sea, habitat availability was expected to reduce with climate change. For North Sea herring, Norwegian cod and Biscay anchovy, climate‐driven changes were expected to have contrasting impacts depending on the life stage. Our review highlights the need to integrate physiological and behavioural processes across the life cycle to project the response of specific populations to climate change.  相似文献   

Morphological and physiological evaluation of common carp (Cyprinus carpio L., 1758) fed extruded compound feeds containing different fat levels     

Vesna Poleksić  Marko Stanković  Zoran Marković  Renata Relić  Nada Lakić  Zorka Dulić  Božidar Rašković 《Aquaculture International》2014,22(1):289-298

The study was carried out to examine morphological and physiological effects of different levels of fat in compound extruded feed for carp. A 90 days experiment was performed in tanks with water flow 0.34 L min^?1, stocked each with 29 specimens of carp, average weight 15.4 ± 4.2 g. The fish was fed 3 diets containing 38 % protein and 8, 12 or 16 % of fat (feed L8, L12, and L16, respectively). Body weight gain, specific growth rate, food conversion ratio, feed efficiency ratio, condition factor, liver and intestine histology and morphometry and some blood biochemical parameters were analysed. At the end of the experiment, a difference was established between the fish fed L8 feed compared to carp fed L12 and L16 feed for all growth parameters. For several other parameters, nuclear area of hepatocytes, nuclear/cytoplasm ratio, enterocytes height and intestinal folds’ length, a difference between carp fed feed L8 compared to feed L16 was found. The histological analysis revealed that normal structure of the liver and intestine prevailed, but changes were observed regardless of the diet type. In the hepatopancreas, more prominent changes were found around pancreatic tissue—particularly, increased number and size of adipocytes. Although blood biochemical parameters were within normal values, a difference between L8 and L16 diet-fed carp was found for plasma levels of triglycerides and total proteins. According to the results obtained in this study, the best results were achieved using a feed with 8 % fat.  相似文献   

Yield,Tuber Quality and Weight Losses During Storage of Ten Potato Cultivars Grown at Three Sites in Serbia     

Zoran Broćić  Željko Dolijanović  Dobrivoje Poštić  Drago Milošević  Jasna Savić 《Potato Research》2016,59(1):21-34

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Integrated use of biological approaches provides effective control of parthenium weed     

Asad Shabbir  Kunjithapatham Dhileepan  Myron Zalucki  Naeem Khan  Steve Adkins 《Archives of Agronomy and Soil Science》2018,64(13):1861-1878

Parthenium weed (Parthenium hysterophorus L.; Asteraceae) is an invasive weed species in agro-ecosystems. It causes huge losses to native biodiversity and agricultural productivity. This study was conducted to assess the combined effect of a leaf-feeding beetle, (Zygogramma bicolorata Pallister; Chrysomelidae) and suppressive plant species, bull Mitchell grass (Astrebella squrossa C.E. Hubb.; Poaceae) or butterfly pea (Clitoria ternatea L.; Fabaceae) on parthenium weed under shade house conditions. The suppressive plant species significantly reduced the parthenium weed height (16%), biomass (29%) and seed production (42%), in the absence of Z. bicolorata. However, this suppressive ability was further enhanced in the presence of Z. bicolorata. The combined effect of the suppressive plant species and Z. bicolorata further reduced the parthenium weed height (46%), biomass (66%) and seed production (95%). The combination also had a significant negative effect upon seed fill, decreasing the reproductive output of the current generation. The presence of Z. bicolorata also had positive effect on the biomass (10%) and plant height (11%) of both suppressive species. So, the combined use of suppressive plant species and the biological control agent suppressed parthenium weed more effectively than their sole use. Such integrated approaches should be prioritized for future management of parthenium weed.  相似文献   

Population dynamics of the diamondback moth,Plutella xylostella (L.), in northern China: the effects of migration,cropping patterns and climate          下载免费PDF全文

Shufa Zhang  Baoyun Xu  Youjun Zhang  Myron P Zalucki  Qingjun Wu  Xianhui Yin 《Pest management science》2018,74(8):1845-1853

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