Regulation of phosphodiesterase synthesis: requirement for cyclic adenosine monophosphate-dependent protein kinase   总被引：7，自引：0，他引：7  

H R Bourne  G M Tomkins  S Dion 《Science (New York, N.Y.)》1973,181(103):952-954

Endogenous cyclic adenosine monophosphate (AMP) and its dibutyryl derivative increase cyclic AMP phosphodiesterase activity in cultured lymphoma cells. This effect is prevented by cycloheximide. A variant population of cells deficient in cyclic AMP-dependent protein kinase contains lower basal phosphodiesterase activity, which cannot be induced by cyclic AMP.  相似文献   

National Speleological Society     

Nicholas G 《Science (New York, N.Y.)》1954,120(3113):5A

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National Speleological Society (E4)     

Nicholas BG  Thrailkill JV 《Science (New York, N.Y.)》1963,139(3555):636

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Senate passes back gene-splice cup     

Wade N 《Science (New York, N.Y.)》1978,200(4348):1368

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Issues in the analysis of contemporary farm protest     

Nicholas R. Ellig 《Agriculture and Human Values》1985,2(2):44-47

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Statement on scientific publication and security     

Atlas R  Campbell P  Cozzarelli NR  Curfman G  Enquist L  Fink G  Flanagin A  Fletcher J  George E  Hammes G  Heyman D  Inglesby T  Kaplan S  Kennedy D  Krug J  Levinson R  Marcus E  Metzger H  Morse SS  O'Brien A  Onderdonk A  Poste G  Renault B  Rich R  Rosengard A  Salzburg S  Scanlan M  Shenk T  Tabor H  Varmus H  Wimmer E  Yamamoto K;Journal Editors  Authors Group 《Science (New York, N.Y.)》2003,299(5610):1149

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Molecular mechanisms for the functionality of lubricant additives     

Mosey NJ  Müser MH  Woo TK 《Science (New York, N.Y.)》2005,307(5715):1612-1615

Wear limits the life-span of many mechanical devices with moving parts. To reduce wear, lubricants are frequently enriched with additives, such as zinc phosphates, that form protective films on rubbing surfaces. Using first-principles molecular dynamics simulations of films derived from commercial additives, we unraveled the molecular origin of how antiwear films can form, function, and dissipate energy. These effects originate from pressure-induced changes in the coordination number of atoms acting as cross-linking agents to form chemically connected networks. The proposed mechanism explains a diverse body of experiments and promises to prove useful in the rational design of antiwear additives that operate on a wider range of surface materials, with reduced environmental side effects.  相似文献   

Recombinant DNA: NIH rules broken in insulin gene project     

Wade N 《Science (New York, N.Y.)》1977,197(4311):1342-1345

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Early origin and recent expansion of Plasmodium falciparum     

Joy DA  Feng X  Mu J  Furuya T  Chotivanich K  Krettli AU  Ho M  Wang A  White NJ  Suh E  Beerli P  Su XZ 《Science (New York, N.Y.)》2003,300(5617):318-321

The emergence of virulent Plasmodium falciparum in Africa within the past 6000 years as a result of a cascade of changes in human behavior and mosquito transmission has recently been hypothesized. Here, we provide genetic evidence for a sudden increase in the African malaria parasite population about 10,000 years ago, followed by migration to other regions on the basis of variation in 100 worldwide mitochondrial DNA sequences. However, both the world and some regional populations appear to be older (50,000 to 100,000 years old), suggesting an earlier wave of migration out of Africa, perhaps during the Pleistocene migration of human beings.  相似文献   

Ultrahigh-density nanowire lattices and circuits     

Melosh NA  Boukai A  Diana F  Gerardot B  Badolato A  Petroff PM  Heath JR 《Science (New York, N.Y.)》2003,300(5616):112-115

We describe a general method for producing ultrahigh-density arrays of aligned metal and semiconductor nanowires and nanowire circuits. The technique is based on translating thin film growth thickness control into planar wire arrays. Nanowires were fabricated with diameters and pitches (center-to-center distances) as small as 8 nanometers and 16 nanometers, respectively. The nanowires have high aspect ratios (up to 10(6)), and the process can be carried out multiple times to produce simple circuits of crossed nanowires with a nanowire junction density in excess of 10(11) per square centimeter. The nanowires can also be used in nanomechanical devices; a high-frequency nanomechanical resonator is demonstrated.  相似文献