Newsmaker interview: Nico Schlaefer. Schooling the Jeopardy! champ: far from elementary. Interview by Karen A. Frenkel     

Schlaefer N 《Science (New York, N.Y.)》2011,331(6020):999

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Successful treatment of sebaceous adenitis in a rabbit with ciclosporin and triglycerides     

Annette Jassies-van der Lee  Yvonne van Zeeland  Marja Kik†  Nico Schoemaker 《Veterinary dermatology》2009,20(1):67-71

A 4-year-old rabbit was presented with a chronic exfoliative dermatitis and patchy alopecia. General physical examination revealed no abnormalities. Skin scrapings and fungal culture were negative. A blood sample was obtained for a complete blood cell count and biochemical profile, and yielded results that were within normal limits. Radiographic examination of the thorax excluded the presence of a thymoma. Histopathology of the skin showed orthokeratotic hyperkeratosis, absence of sebaceous glands and mural lymphocytic folliculitis, consistent with sebaceous adenitis. Oral treatment was started with ciclosporin dissolved in a medium-chain triglyceride solution (Miglyol 812), combined with essential fatty acids and topical propylene glycol sprays. Within 2 months of treatment, complete regression of skin lesions and regrowth of hair was observed. Serum chemistry values including kidney and liver function tests remained within reference range during the course of treatment. Histopathological examination of control biopsies of the skin showed presence of normal sebaceous glands and active hair follicles. Treatment was changed to a different pharmaceutical formulation of ciclosporin without Miglyol and deterioration of clinical signs was noticed. Using pure Miglyol 812, however, resulted in a gradual improvement of 60%. A nearly complete response was again observed after re-administration of the combination ciclosporin/Miglyol. It is hypothesized that sebaceous adenitis in the rabbit is most likely due to an autoimmune reaction directed at the sebaceous glands and a defect in lipid metabolism. The outcome indicates that a combination of ciclosporin and Miglyol 812 is a promising new treatment for sebaceous adenitis in rabbits.  相似文献   

Penaeus monodon (Fabricius) and Penaeus merguiensis (de Man) biculture in East Java, Indonesia     

A M Hariati  D G R Wiadnya  R K Rini  J H Boon  M C J Verdegem 《Aquaculture Research》1998,29(10):743-750

Shrimp farmers in South-East Java have recently observed a decline in Penaeus monodon (Fabricius) production. To stabilize overall production, some farms have switched partially to biculture of P. monodon and P. merguiensis (de Man). The production from 33 ponds in two of these farms was analysed. In addition, the water quality in 10 ponds was monitored over the entire culture period. Information was also available on the post-larvae (PL) source and feed used per pond. Water quality remained stable during the culture period and there was no accumulation of organic material during the second half of the culture period. Stocking P. merguiensis 2 months after P. monodon partially compensated for the low production of P. monodon, thereby stabilizing overall production. When the production of P. monodon is low, the production of P. merguiensis is high and vice versa (P<0.001). Feed source had no effect on production when stocking density was included as a covariable in the analysis (P > 0.05), while P. monodon PL source caused production to differ by a factor of three (P<0.001). It was concluded that biculture of P. monodon and P. merguiensis is an effective way to stabilize overall shrimp production.  相似文献   

Developing a standard approach for assessing the hydromorphology of lakes in Europe     

Philip Boon  Christine Argillier  Angela Boggero  Marzia Ciampittiello  Judy England  Monika Peterlin  Sneana Radulovi&#x;  John Rowan  Hanna Soszka  Gorazd Urbani 《水产资源保护:海洋与淡水生态系统》2019,29(4):655-669

Developing a standard approach for monitoring freshwater pearl mussel (Margaritifera margaritifera) populations in European rivers     

Philip J. Boon  Susan L. Cooksley  Juergen Geist  Ian J. Killeen  Evelyn A. Moorkens  Iain Sime 《水产资源保护:海洋与淡水生态系统》2019,29(8):1365-1379

Clinical Characteristics of 53 Dogs with Doppler-Derived Evidence of Pulmonary Hypertension: 1992–1996     

Lynelle Johnson  June Boon  E. Christopher Orton 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1999,13(5):440-447

Pulmonary hypertension occurs as a primary or secondary disorder of the pulmonary vasculature. Doppler echocardiography provides a noninvasive tool for the estimation of pulmonary arterial pressure when tricuspid regurgitation or pulmonic insufficiency is present. The cardiology database at Colorado State University was reviewed, and echocardiographic records from cases diagnosed with pulmonary hypertension were evaluated. Application of the modified Bernoulli equation to the maximal instantaneous velocity of a right-sided regurgitant jet provided evidence of pulmonary hypertension in 53 dogs over a 4-year period. Tricuspid regurgitant velocity > or = 2.8 m/second or pulmonic insufficiency velocity > or = 2.2 m/second was considered abnormal and indicative of pulmonary hypertension. Tricuspid regurgitant gradients in 51 dogs ranged from 32 to 145 mm Hg (mean, 63.0 mm Hg; median, 57.0 mm Hg; 25th-75th percentiles, 45.2-76.5 mm Hg). Pulmonic insufficiency gradients in 8 dogs ranged from 20 to 100 mm Hg (mean, 59.5 mm Hg; median, 61.5 mm Hg; 25th-75th percentiles, 32.0-84.5 mm Hg). Affected dogs ranged in age from 2 months to 16 years. Clinical signs were characteristic of cardiopulmonary disease, but a relatively high frequency of syncope was noted (12 of 53 dogs, 23%). Pulmonary hypertension was probably due to increased pulmonary vascular resistance in 23 dogs, pulmonary overcirculation in 2 dogs, and pulmonary venous hypertension in 23 dogs. Five dogs lacked a clinically recognizable cardiopulmonary cause of pulmonary vascular disease. Our results suggest that pulmonary hypertension can occur as a complication of commonly encountered cardiopulmonary diseases, and that Doppler echocardiography can facilitate recognition of this condition.  相似文献   

Ecotoxicological Risk Assessment of Pesticides Subject to Long-Range Transport     

van Straalen  Nico M.  van Gestel  Cornelis A.M. 《Water, air, and soil pollution》1999,115(1-4):71-81

Concern has arisen about the possible ecological effects of persistent pesticides that become airborne during or after application and are transported to regions far away from where they were applied. In this paper an ecotoxicological approach is outlined that may support assessments of products suspected of long-range transport capacity. It is proposed that the risk is estimated from a classical PNEC/PEC comparison for the surface layer of a remote area, where PEC is estimated from dose rate, emission factors, atmospheric residence time and persistence, while PNEC is estimated from ecotoxicological information collected as part of the registration procedure. According to this "null model", risk assessment of pesticides subject to long-range transport is not different from the usual risk assessment, provided that due attention is paid to losses occurring during transport and accumulation in remote areas with low temperature. A simplified equation is derived for estimating PEC from the recommended dose rate, which shows that the concentration in the remote area is higher than in the target area only if its residence time is at least two order of magnitude longer than the corresponding value in the target area. A review of ecotoxicity data for effects of volatile pesticides on arthropods indicates that effect levels in the air compartment are far above the concentrations of concern in long-range transport. Arguments supporting the view that remote areas, specifically the polar regions, are characterized by ecosystems that are more vulnerable than the ones on which the usual risk assessment is based, are reviewed. Although residues of organochlorines are of concern, there does not seem to be concrete epidemiological or experimental evidence about effects of modern pesticides on wildlife in remote areas. It is concluded that there is no reason to reject the "null model" at the moment, however, in view of the large uncertainty involved, it is proposed that the maximum acceptable ratio between PNEC and PEC be increased by an extra safety factor.  相似文献   

Out of the dark: Using energy flux to connect above- and belowground communities and ecosystem functioning     

Malte Jochum  Nico Eisenhauer 《European Journal of Soil Science》2022,73(1):e13154

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