Expression of molecular markers in blood of neonatal foals with sepsis     

Pusterla N  Magdesian KG  Mapes S  Leutenegger CM 《American journal of veterinary research》2006,67(6):1045-1049

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A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration   总被引：1，自引：0，他引：1  

Yang Z  Camp NJ  Sun H  Tong Z  Gibbs D  Cameron DJ  Chen H  Zhao Y  Pearson E  Li X  Chien J  Dewan A  Harmon J  Bernstein PS  Shridhar V  Zabriskie NA  Hoh J  Howes K  Zhang K 《Science (New York, N.Y.)》2006,314(5801):992-993

Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss in the developed world and has a strong genetic predisposition. A locus at human chromosome 10q26 affects the risk of AMD, but the precise gene(s) have not been identified. We genotyped 581 AMD cases and 309 normal controls in a Caucasian cohort in Utah. We demonstrate that a single-nucleotide polymorphism, rs11200638, in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49.3%. The HTRA1 gene encodes a secreted serine protease. Preliminary analysis of lymphocytes and retinal pigment epithelium from four AMD patients revealed that the risk allele was associated with elevated expression levels of HTRA1 mRNA and protein. We also found that drusen in the eyes of AMD patients were strongly immunolabeled with HTRA1 antibody. Together, these findings support a key role for HTRA1 in AMD susceptibility and identify a potential new pathway for AMD pathogenesis.  相似文献   

Unusual histiocytic disease in a Somali cat     

Reed N  Begara-McGorum IM  Else RW  Gunn-Moore DA 《Journal of Feline Medicine and Surgery》2006,8(2):129-134

An 8-year-old Somali cat presented with a 9-month history of inappetence, vomiting and weight loss. The disease progressed to involve neurological signs associated with a mass lesion at the level of the first lumbar vertebra. Histopathology identified the condition as malignant histiocytosis affecting the lungs, stomach, mesenteric lymph nodes, liver, spleen, brain and spinal cord. However, the presentation of this case differs from previously reported cases of malignant histiocytosis, and may therefore represent a variant form of histiocytic disease.  相似文献   

Assessment of the influence of surgical technique on postoperative pain and wound tenderness in cats following ovariohysterectomy     

Grint NJ  Murison PJ  Coe RJ  Waterman Pearson AE 《Journal of Feline Medicine and Surgery》2006,8(1):15-21

Elective ovariohysterectomy was performed on 66 cats. Surgical approach was flank (group F) or midline (group M) allocated by block randomisation. Pre-anaesthetic medication was acepromazine (0.1 mg/kg) via intramuscular injection. Anaesthesia was induced with intravenous thiopentone, and maintained with halothane in 100% oxygen. Carprofen (4 mg/kg) was administered by the subcutaneous route immediately after induction of anaesthesia. Postoperative pain and wound tenderness were assessed at 1, 3, 6, 9, 11-12 and 20-24h after the end of surgery, and the assessment outcome marked on visual analogue scales (VAS). Intervention analgesia (if pain VAS was >40 mm) was pethidine 4 mg/kg via intramuscular injection. Area under the curve (AUC) for VAS for pain and VAS for wound tenderness for each cat were calculated. AUC for wound tenderness was significantly greater for group F (P = 0.007). There was no significant difference for AUC for pain between the groups. In conclusion, wounds after flank ovariohysterectomy are significantly more tender than after midline ovariohysterectomy in the cat. This indicates that interactive methods, including wound palpation, must be used to assess postoperative pain and the findings should be appropriately weighted in the overall assessment.  相似文献   

The social regulation of transnational migration: Perspectives from the Asia Pacific          下载免费PDF全文

Nicola Piper  Gaby Ramia 《Asia Pacific viewpoint》2018,59(1):87-91

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Comparison of corneal degeneration and calcific band keratopathy from 2000 to 2013 in 69 horses          下载免费PDF全文

Emily H. Berryhill  Sara M. Thomasy  Philip H. Kass  Christopher M. Reilly  Kathryn L. Good  Steven R. Hollingsworth  David J. Maggs  K. Gary Magdesian  Nicola Pusterla 《Veterinary ophthalmology》2017,20(1):16-26

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Genetic variation within species and haplotypes of the Wiseana (Lepidoptera: Hepialidae) complex and development of non‐sequenced based identification tools to aid field studies          下载免费PDF全文

Nicola K Richards  Sarah Mansfield  Richard J Townsend  Colin M Ferguson 《Pest management science》2017,73(11):2334-2344

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Otter occupancy in the Cape Peninsula: Estimating the probability of river habitat use by Cape clawless otters,Aonyx capensis,across a gradient of human influence          下载免费PDF全文

Nicola C. Okes  M. Justin O'Riain 《水产资源保护:海洋与淡水生态系统》2017,27(3):706-716

What constitutes effective governance of recreational fisheries?—A global review     

Warren M. Potts  Nicola Downey‐Breedt  Pablo Obregon  Kieran Hyder  Roy Bealey  Warwick H. H. Sauer 《Fish and Fisheries》2020,21(1):91-103

The effectiveness of recreational fisheries governance has been mixed, with some countries boasting good governance practices that sustain productive recreational fisheries, while others lack any policies and governance structures specific to recreational fisheries. Here, we identify what constitutes effective governance of recreational fisheries by carrying out: (a) a desktop review of 227 country‐specific fisheries legislation, policies and strategies; and (b) a follow‐up questionnaire‐based survey covering 57 contacts in 29 selected countries. Our results show that while recreational fishing is referred to in the main legislation of 67% of the countries reviewed, only 86 of these 152 countries provide a definition for either “recreational” or “sport” fishing and not always in the main legislation. Recreational fisheries are not considered to be effectively managed in many countries, with less than a quarter of respondents claiming that management in their country is effective. Furthermore, the management efficacy, including compliance with regulations, was considered greater for the industrial and small‐scale fishing sectors than for recreational fisheries in most countries. From our findings, it appears that effective recreational fisheries governance requires explicit acknowledgement of recreational fisheries with a clear legal definition in Policy, a well‐developed Policy statement, extensive co‐management processes, clearly defined biological, economic and social monitoring structures and efficient and transparent cost recovery mechanisms. To ensure adaptation to rapidly changing conditions, policy should recognize all fishery sectors and proactively incorporate adaptive planning and contingency plans to effectively secure the diverse values of resources for all users.  相似文献   

Changing distribution of the east coast of Scotland bottlenose dolphin population and the challenges of area‐based management     

Mnica Arso Civil  Nicola J. Quick  Barbara Cheney  Enrico Pirotta  Paul M. Thompson  Philip S. Hammond 《水产资源保护:海洋与淡水生态系统》2019,29(Z1):178-196