排序方式: 共有13条查询结果,搜索用时 6 毫秒
11.
Shoma MIKAWA Shohei YAMAMOTO Md Shafiqul ISLAM Noriyuki KAJI Takahisa MURATA Risuke MIZUNO Hiroshi OZAKI Masatoshi HORI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(10):1195-1199
Maropitant is a neurokinin 1 receptor (NK1R) antagonist that is clinically used as a new
anti-emetic drug for dogs. Substance P (SP) and its receptor NK1R are considered to
modulate gastrointestinal peristalsis. In addition, SP works as an inflammatory mediator
in gastrointestinal diseases. Aim of this study is to clarify the effects of maropitant on
intestinal motility and inflammation in mice. Ex vivo examination of
luminal pressure-induced intestinal motility of whole intestine revealed that maropitant
(0.1–10 µM) increased frequency of contraction, decreased amplitude of
contraction and totally inhibited motility index in a concentration-dependent manner. We
measured intestinal transit in vivo by measuring transportation of orally
administered luminal content labeled with phenol red. Our results demonstrated that
maropitant (10 mg/kg, SC) delayed intestinal transit. Geometric center value was
significantly decreased in maropitant-treated mice. Anti-inflammatory effects of
maropitant against leukocytes infiltration into the intestinal smooth muscle layer in
post-operative ileus (POI) model mice were measured by immunohistochemistry. In POI model
mice, a great number of CD68-positive macrophages or MPO-stained neutrophils infiltrated
into the inflamed muscle region of the intestine. However, in the maropitant treated mice,
the infiltration of leukocytes was not inhibited. The results indicated that maropitant
has ability to induce disorder of intestinal motility in mice, but has no
anti-inflammatory action in the mouse of a POI model. In conclusion, in mice, maropitant
induces disorder of intestinal motility in vivo. 相似文献
12.
Yusuke HORI Takatoshi OZAKI Yoshimitsu YAMADA Teruaki TOZAKI Heui-Soo KIM Ayaka TAKIMOTO Maiko ENDO Noboru MANABE Miho INOUE-MURAYAMA Kazuo FUJITA 《Journal of Equine Science》2013,24(3):31-36
Genetic polymorphisms in genes related to neurotransmitters or hormones affect
personality or behavioral traits in many animal species including humans. In domestic
animals, the allele frequency of such genes has been reported to be different among breeds
and it may account for breed differences in behavior. In this study, we investigated breed
differences in horses in the dopamine receptor D4 gene (DRD4), which has been reported to
affect horse personality. We collected samples from seven horse breeds including those
native to Japan and Korea, and compared the sequence of the DRD4 exon3 region among these
breeds. We found that there were two types of polymorphisms (VNTR and SNPs) in the exon3
region, and some of them seemed to be breed-specific. In addition, we found that the
allele frequency of G292A, reported to be associated with horse personality, differed
greatly between native Japanese horses and Thoroughbred horses. The frequency of the A
allele which is associated with low curiosity and high vigilance, was much lower in native
Japanese horses (Hokkaido, 0.03; Taishu, 0.08) than in Thoroughbreds (0.62). This
difference may account for breed differences in personality or behavioral traits. Further
studies of the function of these polymorphisms and their effect on behavior are
indicated. 相似文献
13.
Kosuke SODA Hiroichi OZAKI Hiroshi ITO Tatsufumi USUI Masatoshi OKAMATSU Keita MATSUNO Yoshihiro SAKODA Tsuyoshi YAMAGUCHI Toshihiro ITO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(12):1891
Large highly pathogenic avian influenza (HPAI) outbreaks caused by clade 2.3.4.4e H5N6 viruses occurred in Japan during the 2016–2017 winter. To date, several reports regarding these outbreaks have been published, however a comprehensive study including geographical and time course validations has not been performed. Herein, 58 Japanese HPAI virus (HPAIV) isolates from the 2016–2017 season were added for phylogenetic analyses and the antigenic relationships among the causal viruses were elucidated. The locations where HPAIVs were found in the early phase of the outbreaks were clustered into three regions. Genotypes C1, C5, and C6–8 HPAIVs were found in specific areas. Two strains had phylogenetically distinct hemagglutinin (HA) and non-structural (NS) genes from other previously identified strains, respectively. The estimated latest divergence date between the viral genotypes suggests that genetic reassortment occurred in bird populations before their winter migration to Japan. Antigenic differences in 2016–2017 HPAIVs were not observed, suggesting that antibody pressure in the birds did not contribute to the selection of HPAIV genotypes. In the late phase, the majority of HPAI cases in wild birds occurred south of the lake freezing line. At the end of the outbreak, HPAI re-occurred in East coast region, which may be due to the spring migration route of Anas bird species. These trends were similar to those observed in the 2010–2011 outbreaks, suggesting there is a typical pattern of seeding and dissemination of HPAIV in Japan. 相似文献