Perceived subject outcomes and impact on health-related quality of life associated with diet using the new Food Benefits Assessment (FBA) questionnaire: development and psychometric validation     

Guyonnet D  Chassany O  Picard C  Guillemin I  Meunier J  Seignobos E  Vigneux M  Lassel T  Trudeau E 《Public health nutrition》2008,11(11):1163-1172

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Liposome encapsulation and EDTA formulation of dsRNA targeting essential genes increase oral RNAi‐caused mortality in the Neotropical stink bug Euschistus heros     

Nathaly L Castellanos  Guy Smagghe  Rohit Sharma  Eugênio E Oliveira  Olivier Christiaens 《Pest management science》2019,75(2):537-548

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Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes     

Marilia Barreca  Virginia Span  Alessandra Montalbano  Mercedes Cueto  Ana R. Díaz Marrero  Irem Deniz  Ayegül Erdoan  Lada Luki&#x; Bilela  Corentin Moulin  Elisabeth Taffin-de-Givenchy  Filippo Spriano  Giuseppe Perale  Mohamed Mehiri  Ana Rotter  Olivier P. Thomas  Paola Barraja  Susana P. Gaudêncio  Francesco Bertoni 《Marine drugs》2020,18(12)

The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use.  相似文献   

2018 Awards for significant contributions to veterinary anaesthesiology     

Shannon M. Axiak Flammer  Olivier Levionnois 《Veterinary anaesthesia and analgesia》2019,46(1):2-3

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A surgical approach to the lateral compartment of the equine guttural pouch in the standing horse: modification of the forgotten "Garm technique"     

Muñoz JA  Stephen J  Baptiste KE  Lepage OM 《Veterinary journal (London, England : 1997)》2008,177(2):260-265

The objective of this study was to evaluate the feasibility, efficacy and complications following lavage and drainage of the lateral compartment (LC) of the equine guttural pouch (GP) using a modified Garm's technique (MGT). In an ex vivo study (study 1), six cadaver heads were examined to assess the anatomical limits of the surgical approach and whether vital structures might be damaged. This was followed by an in vivo study (study 2) in which a lavage/drainage tube was placed for 3 days into each LC of four standing horses using the MGT. In both studies, the procedure offered direct access into the LC and indirect access into the medial compartments of the GP. In study 1, the MGT provided a rostroventral point of access allowing drainage of the LC, with no obvious iatrogenic damage. In study 2, the MGT permitted lavage of the entire GP in three healthy horses and one horse with mild GP empyema. The only major complication was development of emphysema of the lateral wall of one LC, with secondary collapse of the mucous membrane. The time for secondary wound healing was 12-14 days. The MGT can be performed safely in standing horses and may be of value in providing access for lavage and drainage in horses with mild GP empyema.  相似文献   

Estimating direct genetic and maternal effects affecting rabbit growth and feed efficiency with a factorial design     

Herv Garreau  Julien Ruesche  Hlne Gilbert  Elodie Balmisse  Florence Benitez  Franois Richard  Ingrid David  Laurence Drouilhet  Olivier Zemb 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2019,136(3):168-173

The aim of this experiment was to evaluate the significance of neonatal environment on feed efficiency. For that purpose, rabbits from a line selected for residual feed intake (RFI) during 10 generations (G10 kits) were cross‐fostered with non‐selected control does (i.e., G0 line), and reciprocally. In parallel, sibs were fostered by mothers from their original line. Nine hundred animals were raised in individual (N = 456) or collective (N = 320) cages. Traits analysed in this study were body weight at 32 days and at 63 days, average daily gain (ADG), feed intake between weaning and 63 days (FI), feed conversion ratio (FCR) and RFI. The maternal environment offered by does from the line selected for RFI deteriorated the FCR of the kits, independently of their line of origin, during fattening (+0.08 ± 0.02) compared to FCR of kits nursed by G0 does. The line, the type of housing and the batch were significant effects for all the measured traits: G10 kits were lighter than their G0 counterparts at 32 days (?82.9 ± 9 g, p < 0.0001) and at 63 days (?161 ± 16 g, p < 0.0001). They also had a lower ADG (?2.36 ± 0.36 g/day, p < 0.0001), RFI (?521 ± 24 g/day, p < 0.0001) and a lower FI (?855 ± 31 g, p < 0.0001), resulting in a more desirable feed efficiency (FCR: ?0.35 ± 0.02). There was no significant difference in the contrast of G10 and G0 performances between collective and individual/digestive cages (p > 0.22): ?2.35 g/day versus 2.94 g/day for ADG, ?0.39 versus ?0.40 for FCR, ?577 g versus ?565 g for RFI and ?879 g versus ?859 g for FI, respectively). Thus, no genotype‐by‐environment (housing) interaction is expected at the commercial level, that is, no re‐ranking of the animals due to collective housing.  相似文献   

Matrix transformation alters species-area relationships in fragmented coastal forests     

Marc T. Freeman  Pieter I. Olivier  Rudi J. van Aarde 《Landscape Ecology》2018,33(2):307-322

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MuSeeQ,a novel supervised image analysis tool for the simultaneous phenotyping of the soluble mucilage and seed morphometric parameters     

Fabien Miart  Jean-Xavier Fontaine  Christophe Pineau  Hervé Demailly  Brigitte Thomasset  Olivier Van Wuytswinkel  Karine Pageau  François Mesnard 《Plant methods》2018,14(1):112

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Effects of esmolol on systemic hemodynamics and heart rate variability measured using the Analgesia/Nociception Index in resuscitated piglets with Pseudomonas aeruginosa septic shock          下载免费PDF全文

Emmanuel Boselli MD  PhD  Matthias Jacquet‐Lagrèze MD  Jean‐Yves Ayoub DVM  Lionel Bouvet MD  PhD  Olivier Dauwalder PharmD  PhD  Christelle Mansour DVM  Thomas Margez Eng  Christian Paquet Eng  Damien Restagno MSc  Bernard Allaouchiche MD  PhD  Jeanne‐Marie Bonnet‐Garin DVM  PhD  Stéphane Junot DVM  PhD 《Journal of Veterinary Emergency and Critical Care》2018,28(5):447-456

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Growing American ginseng in maple forests as an alternative land-use system in Québec, Canada     

I. Nadeau  A. Olivier  R. R. Simard  J. Coulombe  S. Yelle 《Agroforestry Systems》1998,44(2-3):345-353

American ginseng (Panax quinquefolium) is a medicinal crop which provides tens of millions of dollars in income every year for Canadian farmers. Most of the ginseng roots are produced in open fields under expensive shade structures. Farmers need to plant ginseng at a very high density to achieve profitability. Since high planting densities are related to high disease levels, field-cultivated ginseng requires frequent applications of pesticide. Growing ginseng in forests eliminates the need of a shade structure and may reduce the need for pesticides. Thus, an experiment was performed in a maple (Acer rubrum) forest in Québec to evaluate the effects of nutrient inputs such as lime or compost on ginseng development. Ginseng emergence and survival rates, leaf area and foliar and root weight were evaluated for each treatment. Soil samples were taken in each plot to determine the concentration of various soil nutrients. During the first two years of the experiment, it was noted that the application of lime had a significative positive effect on ginseng growth. This effect could be related to higher calcium concentration and/or lower aluminium toxicity. Liming would be an efficient way to improve the early development of ginseng in maple forests. This practice is also known to improve the health of maple stands. This revised version was published online in June 2006 with corrections to the Cover Date.  相似文献