Efficacy and safety of selamectin against gastrointestinal nematodes in cats presented as veterinary patients     

Six RH  Sture GH  Thomas CA  Clemence RG  Benchaoui HA  Boy MG  Watson P  Smith DG  Jernigan AD  Rowan TG 《Veterinary parasitology》2000,91(3-4):321-331

A series of randomized, controlled, masked, field (veterinary patient) studies were conducted in the USA and Europe to evaluate the efficacy of selamectin, a novel macrocyclic lactone of the avermectin subclass, in the treatment of naturally acquired gastrointestinal nematode infections in cats. After confirmation of ascarid and/or hookworm infection, 298 cats of various ages and breeds were randomly assigned to treatment with selamectin (n=202) or an existing commercially approved positive-control product (n=96). Unit doses of selamectin (providing a minimum dosage of 6mgkg(-1)) were administered topically to the skin in a single spot at monthly intervals. Quantitative fecal examinations were performed on days 0 (before treatment), 30, and 60. In the selamectin-treated cats, fecal ascarid egg counts were reduced by 99.6 to 100% on day 30, and by 99.9 to 100% on day 60. Fecal hookworm egg counts were reduced by 98.3% on day 30, and by 100% on day 60 in the selamectin-treated cats. The positive-control products achieved reductions in egg counts of 96.5 to 100% (ascarids) and 98.9 to 99.9% (hookworms). These studies have shown that monthly topical administration of selamectin is safe and highly effective in the treatment of naturally acquired ascarid and hookworm infections in cats.  相似文献   

Landscape improvement, or ongoing degradation – reconciling apparent contradictions from the arid rangelands of Western Australia     

Hugh J. R. Pringle  Ian W. Watson  Ken L. Tinley 《Landscape Ecology》2006,21(8):1267-1279

Recent quantitative site-based monitoring and qualitative aerial and ground traverses provide contrasting assessments of the health of much of the arid shrublands of Western Australia extensively grazed by livestock (‘rangelands’). Although these results seem incompatible, we explain the apparent contradictions based on landscape succession processes operating at multiple levels of ecological organisation. Specifically, we suggest that the intact areas in which site-based monitoring is conducted are contracting as catchment canalisation and desiccation increase. However, the impacts of these processes have not yet become manifest at the site scale. The site-based system addresses important regional questions. These relate to the large, relatively intact areas away from most active surface flows, which should be a focus for resource conservation, given practical limits to repairing widespread degradation with low management inputs. We provide a complementary set of questions to provide a more comprehensive audit of rangeland dynamics in the context of underlying hierarchical landscape patterns and processes that might threaten intact areas. We recognise the need to match questions and levels of ecological organisation and the implications these have for sampling. We also recognise the difficulty in producing concise statements of change for clients when reporting on complex ecological issues and processes. Without a clearly articulated, and well understood, hierarchical model of pattern and process within which apparently contradictory findings can be reported meaningfully, policy makers may be confused by the results, with the consequent risk of policy inaction.  相似文献   

Soil physical fertility, soil structure and rooting conditions after ploughing organically managed grass/clover swards     

B. C. Ball    C. A. Watson  & J. A. Baddeley 《Soil Use and Management》2007,23(1):20-27

Effective management of soil structure and organic matter are essential in organic cropping to ensure good rooting conditions and to optimize the production of mineralized N and thus minimize greenhouse gas emissions. We investigated how mid‐winter or early spring ploughing and three grazing duration treatments prior to ploughing influenced soil structure, soil organic matter and plant root growth under the first spring barley crop after a grass–clover ley. The experiment was carried out over two seasons. We also studied the soil under first‐year oats in a long‐term rotations experiment where 2 or 3 years of arable crops followed 3 or 4 years of grass. Pore size distribution and pore continuity, bulk density, particulate (light fraction) organic matter, readily oxidizable organic matter (ROM), aggregate size distribution and root length densities were measured. Macroporosity appeared to be the best indicator of soil physical fertility; it was sensitive to changes in soil structure arising from compaction and root growth. This, along with visual examination, revealed the loosening resulting from ploughing. The generally favourable macroporosity amongst small, stable aggregates reduced the likelihood of development of anaerobism. Macroporosity and aggregate size can be estimated from visual examination of the soil, a method that offers the advantage of being quick and of sampling a large volume. The content of ROM was high 6.1–6.4 g 100 g^?1 whole soil. However, particulates formed only a small fraction (6–9%) of the ROM. Despite the favourable ROM and structure, the soil was susceptible to compaction damage during seedbed preparation in wet soil after ploughing which reduced grain yield in some plots. Grazing by sheep before ploughing and date of ploughing had minor effects on soil quality. Grazing for 2 months prior to ploughing increased root length density in the upper topsoil in the following arable crop, possibly because of the higher quality of the animal and grass–clover residues. Conservation of soil quality was related more to secondary tillage and sowing operations after ploughing than to duration and timing of grazing.  相似文献   

Pharmacokinetics of oxfendazole in red deer (Cervus elaphus)     

T G Watson  T R Manley 《Research in veterinary science》1985,38(2):231-233

The pharmacokinetics of oxfendazole (OFZ) in red deer (Cervus elaphus) was examined. OFZ, administered per os at 4.53 mg kg-1, was extracted in ether from plasma and identified and concentrations estimated by high pressure liquid chromatography. Irrespective of whether the animals were fed concentrates indoors as pellets or grass while on pasture, OFZ was absorbed rapidly. Concentrations of OFZ in plasma reached maxima within 20 hours (0.83 and 1.005 mg litre-1 respectively) and were undetectable 36 hours after administration. Fenbendazole was not detected at any time in the chromatograms. Metabolism of OFZ occurred rapidly producing the sulphone metabolite. In comparison with published data for OFZ in sheep, red deer appear to metabolise OFZ and excrete OFZ sulphone at much faster rates. Consequently, anthelmintic efficacy is likely to vary from species to species.  相似文献   

A New Light Microscopy Classification of Spermatogenesis in the Bull and the Boar Applicable to Tissues Processed for Electron Microscopy     

R. F. L. Suswillo  P. F. Watson 《Anatomia, histologia, embryologia》1990,19(4):326-339

A new light microscopy classification of spermatogenesis in the bull and the boar was formulated to be used in conjunction with electron microscopy. It uses information available from all cell types and allows for very small portions of testicular epithelium at any orientation to be evaluated. The classification devised, being simple in outline, allows for the natural overlap of cell types. Furthermore, it emphasises the direct comparability of the morphological events occurring during spermatogenesis in the bull and the boar.  相似文献   

"FLORIDA WEATHER"     

Watson JR 《Science (New York, N.Y.)》1912,36(918):147-148

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A COMPARISON BETWEEN A PADDOCK SYSTEM AND A 'WYE COLLEGE' SYSTEM OF GRAZING FOR MILK PRODUCTION     

M. E. Castle  J. N. Watson 《Grass and Forage Science》1973,28(1):7-12

Two grazing systems, a paddock system and a ‘Wye College’ system, were compared in two 20-week experiments nsing 16 and 20 spring-calved Ayrshire cows in 1970 and 1971, respectively. A sward of S23 perennial ryegrass was used, and an average of 342 kg N/ha (305 lb N/ ac) was applied per annum. The paddock system had 28 separate paddocks; one paddock was grazed each day in rotation and occasionally topped in mid-season. The Wye College system had 4 plots of equal size and the cows were offered 1/7 of one plot each day; no back fence was used and surplus herbage was neither cut nor topped. The stocking rate on hoth systems was 1 cow per 0.20 ha (0.49 ac) in 1970 and per 0.16 ha (0.40 ac) in 1971. The mean daily milk yields per cow on the paddock and the Wye College systems were 16.2 and 15.3 kg (35.7 and 33.7 lb), respectively, in 1970; and 18.1 and 18.4 kg (39.9 and 40.6 lb) in 1971. The average annual output of milk was 13,500 and 13,150 kg/ha (1200 and 1170 gal/ac) on the paddock and Wye College systems, respectively. The fat and solids-not-fat (S.N.F.) contents of the milk were not significantly affected by the grazing system. It is concluded that the Wye College system was as effective as the paddock system in producing a high output of mUk per ha, but at a lower cost and with far fewer management decisions.  相似文献   

Determination of 10 carcinogenic polycyclic aromatic hydrocarbons in mainstream cigarette smoke     

Ding YS  Ashley DL  Watson CH 《Journal of agricultural and food chemistry》2007,55(15):5966-5973

Polycyclic aromatic hydrocarbons (PAHs) are one class of chemical compounds that (1) are present at low to trace levels in unburned cigarette filler, and (2) are predominantly generated during combustion. According to a recent report of the International Agency for Research on Cancer, 10 carcinogenic PAHs together with 53 other known carcinogens are present in cigarette smoke. Accurate quantification of these chemicals helps assess public health risk to both smokers and nonsmokers exposed to second-hand smoke. We have developed and validated a specific and sensitive method for measuring these 10 carcinogenic PAHs in the particulate phase of mainstream tobacco smoke. Cigarette smoke particulate, produced using standard machine smoking protocols, was collected on glass fiber Cambridge filter pads. The particulate matter was solvent extracted, purified by solid-phase extraction, and analyzed by liquid chromatography/atmospheric pressure photoionization tandem mass spectrometry using isotopically labeled analogues as internal standards. Our method's limits of detection ranged from 11 to 166 pg and achieved sufficient reproducibility and accuracy to provide useful information on a range of cigarettes having dramatically different machine-smoked tar and nicotine deliveries. The identity of each PAH analyte was established from chromatographic retention time, analyte-specific fragmentation patterns, and relative peak area ratios of the product/precursor ion pairs. This new method provides higher sensitivity, specificity, and throughput than did earlier methods. We found relatively consistent PAH levels among a selection of domestic full-flavor cigarettes. The PAH levels in smoke from highly ventilated light and ultralight cigarettes were low when smoked using ISO (International Organization for Standardization) conditions. However, if highly ventilated cigarettes were smoked under more intense conditions (e.g., larger or more frequent puffs, vents blocked), their PAH levels equaled or exceeded their full-flavor counterparts under ISO conditions.  相似文献   

Serum Biomarkers of Clinical and Cytologic Response in Dogs with Idiopathic Immune‐Mediated Polyarthropathy     

J.D. Foster  S. Sample  R. Kohler  K. Watson  P. Muir  L.A. Trepanier 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2014,28(3):905-911

Background

Immune‐mediated polyarthopathy (IMPA) is common in dogs, and is monitored by serial arthrocenteses.

Hypothesis/Objectives

Plasma C‐reactive protein (CRP), interleukin‐6 (IL‐6), and CXCL8 (interleukin‐8) would serve as noninvasive markers of joint inflammation in IMPA.

Animals

Nine client‐owned dogs with idiopathic IMPA; 6 healthy controls.

Methods

Prospective study. Plasma CRP, IL‐6, and CXCL8 were measured by ELISA at baseline, 2, and 4 weeks during treatment with prednisone at 50 mg/m²/day. Arthrocenteses, the canine brief pain inventory (CBPI), and accelerometry collars were used to assess joint inflammation, lameness, and mobility at all 3 time points.

Results

C‐reactive protein concentrations were higher in IMPA dogs (median 91.1 μg/mL, range 76.7–195.0) compared with controls (median <6.3 μg/mL, <6.3–13.7; P = .0035), and were significantly lower at week 2 (10.6 μg/mL, <6.3–48.8) and week 4 (<6.3 μg/mL, <6.3–24.4; P < .001).C‐reactive protein was correlated with median CBPI scores (r = 0.68; P = .0004), joint cellularity (r = 0.49, P = .011), and mobility by accelerometry (r = −0.42, P = .048). Plasma IL‐6 concentrations were also higher in IMPA dogs (median 45.9 pg/mL), compared with controls (median <15.7 pg/mL; P = .0008). IL‐6 was lower in IMPA dogs by week 4 (<15.7 pg/mL; P = .0099), and was modestly correlated with CBPI scores (r = 0.47, P = .023). CXCL8 did not differ significantly between IMPA and healthy dogs.

Conclusions

Plasma CRP and IL‐6 might be useful surrogate markers of synovial inflammation and disease activity in dogs with IMPA.  相似文献   

Artificial Reefs, the Attraction-production Issue, and Density Dependence in Marine Ornamental Fishes     

Jacqueline Wilson  Craig W. Osenberg  Colette M. St. Mary  Craig A. Watson  William J. Lindberg 《Aquarium Sciences and Conservation》2001,3(1-3):95-105

Artificial reefs may provide a useful tool to enhance production of marine ornamentals and to divert detrimental harvesting activities from sensitive natural habitat. The efficacy of this strategy depends, in part, on the extent to which artificial reefs contribute to new production (vs. attract fishes from natural habitat) and therefore benefit harvested populations on a local and regional basis. Here the attraction and production hypotheses and their application to marine ornamentals are presented. Specifically, it is discussed how the strength and timing of density dependence can affect the response of fish population dynamics to artificial reefs. In addition to this discussion, examples of density dependence in marine ornamentals and related reef fishes are provided. Based on this information, a simple conceptual model is presented to clarify the role of density dependence, and this is followed by a discussion on the use of artificial reefs in the management and production of marine ornamentals. Finally, unresolved scientific issues that remain to be addressed are provided.  相似文献