Treatment of cutaneous T-cell lymphoma with dacarbazine in a dog   总被引：1，自引：0，他引：1  

STEPHEN L. LEMARIÉ  SUSAN M. EDDLESTONE 《Veterinary dermatology》1997,8(1):41-46

Abstract Epitheliotropic cutaneous T-cell lymphoma in a Lhasa Apso dog treated with dacarbazine is reported. Clinical disease consisted of a 4 × 4-cm ulcerated mass over the mandibular symphysis and bilateral lymphadenopathy of the submandibular lymph nodes. Skin biopsy sections were díagnostic for epitheliotropic cutaneous T-cell lymphoma, and immunohistochemistry staining for the CD3 antigen was positive. Tissue samples were submitted for chemosensitivity testing and dacarbazine was shown to be 60% effective. Treatment with dacarbazine resulted in total clinical remission. The dog remains disease free 1 year after treatment. Résumé— Les auteurs décrivent un cas de lymphome cutané T épithéliotrope chez un Lhassa Apso traitéà la dacarbazine. Le tableau clinique était caractérisé par la présence d'une masse ulcérée de 4 × 4 cm sur la symphyse mandibulaire et par une adénopathie bilatérale des ganglions sous mandibulaires. Les biopsies posèrent le díagnostic de lymphome cutané T et l'immunomarquage fut positif pour l'antigène CD3. Des prélèvements tissulaires fürent soumis à des tests de chimiosensibilité et la dacarbazine se révéla efficace à 60%. Le traitement à la dacarbazine entraina une rémission clinique totale. Le chien ne présente pas de récidive un an après le traitement. [Lemarié, S. L., Eddlestone, S. M. Treatment of cutaneous T-cell lymphoma with dacarbazine in a dog. (Traitement d'un lymphome cutané T à la dacarbazine chez un chien.) Veterinary Dermatology 1997; 8 : 41–46.] Resumen Se describe el tratamiento con dacarbazina de un linfoma cutáneo epiteliotrópico de células T en un Lasha Apso. La presentación clinica consistia en una masa ulcerada de 4 × 4 cm por encima de la sinfisis mandibular y linfadenopatia bilateral de los ganglios linfáticos submandibulares. El estudio histológico cutáneo permitió un díagnóstico de linfoma cutáneo epiteliotrópico de celulas T, con positividad inmunohistoquimica al antigeno CD3. Se remitieron muestras tisulares para pruebas de quimiosensibilidad, en las que la dacarbazina mostró una efectividad del 60%. El tratamiento con dacarbazina llevó a una remisión clinica total. El perro sigue sano un año después del tratamiento. [Lemarié, S. L., Eddlestone, S. M. Treatment of cutaneous T-cell lymphoma with dacarbazine in a dog. (Tratamiento del linfoma cutáneo de celulas T con dacarbazina en un perro.) Veterinary Dermatology 1997; 8 : 41–46.] Zusammenfassung— Es wird über eine epitheliotropes kutanes T-Zell-Lymphom bei einem Lhasa Apso berichtet, das mit Dacarbazin behandelt wurde. Die klinische Erkrankung bestand in einer 4 × 4 cm großen ulzerierten Masse über der Symphyse der Mandibula sowie einer bilateralen Lymphadenopathie der submandibulären Lymphknoten. Die Hautbiopsien ergaben die Diagnose epitheliotropes kutanes T-Zell-Lymphom, die immunohistochemische Färbung auf CD3-Antigen fiel positiv aus. Die Gewebsproben wurden einer Chemosensitivitätsprobe unterzogen und Dacarbazin erwies sich zu 60% wirksam. Die Behandlung mit Dacarbazin führte zu einer vollständigen klinischen Remission. Der Hund blieb frei von Krankheitssymptomen seit einem Jahr nach der Behandlung. [Lemarié, S. L., Eddlestone, S. M. Treatment of cutaneous T-cell lymphoma with dacarbazine in a dog. (Die Behandlung eines kutanen T-Zell-Lymphom mit Dacarbazin bei einem Hund.) Veterinary Dermatology 1997; 8 : 41–46.]  相似文献   

THE ORIGIN AND DEVELOPMENT OF BROWN EARTHS ON CLAY-WITH-FLINTS AND COOMBE DEPOSITS     

B. W. AVERY  I. STEPHEN  G. BROWN  D. H. YAALON 《European Journal of Soil Science》1959,10(2):177-195

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Serum Levels of Type III Procollagen Peptide in Equidae before and after Intestinal Ischemia     

KAREN J. WHITEHAIR DVM    JILL E. PARKER VMD    GERALD N. SMITH Jr.  PhD  STEPHEN B. ADAMS DVM  MS  Dipiomate ACVS  GERALD B. BOTTOMS PhD 《Veterinary surgery : VS》1991,20(5):311-315

Serum levels of type III procollagen peptide (P-III-P) were measured by radioimmunoassay in clinically normal adult ponies (n = 15) and horses (n = 10). The mean serum levels of P-III-P from the ponies, 10.4 +/- 2.9 (SD) ng/mL, and the horses, 12.2 +/- 2.6 (SD) ng/mL, were not significantly different. Segments of jejunum were made ischemic to induce fibrous peritoneal adhesions in two ponies, and serum P-III-P levels were measured on days 4, 5, 7, 14, and 21. An exploratory celiotomy on day 21 revealed that the ischemic injury had induced fibrosis of the mesentery and bowel, but no adhesions had formed. The fibrotic mesentery contained type III collagen. The highest mean serum level of P-III-P, 23.0 +/- 3.5 (SD) ng/mL on day 7, was more than 4 SD above the mean from the normal ponies. There was a significant difference in the serum P-III-P levels in the ponies on days 0 (7.1 +/- 1.6 ng/mL) and 7 (23.0 +/- 3.5 ng/mL). Serum levels of P-III-P may be useful to study fibrosis associated with intestinal ischemia.  相似文献   

Surgical Management of Traumatic Atlanto-Occipital Instability in a Dog     

STEPHEN W. CRANE D.V.M. 《Veterinary surgery : VS》1978,7(2):39-42

An unusual case of atlanto-occipital instability resulted from traumatic disruption of the lateral atlanto-occipital ligament and fracture dislocation of the dens in a 13-month-old male Basset Hound. Initial treatment was traction-immobilization splintage followed by decompressive dorsal laminectomy of the atlas. Wiring the wing of the atlas to the base of the occipital condyle provided lateral, rotational and dorsoventral stability of the atlanto-occipital articulation.  相似文献   

Transdiaphragmatic Approach for Permanent Cardiac Pacemaker Implantation in Dogs     

JAMES M. FINGEROTH dvm  STEPHEN J. BIRCHARD dvm  MSc  Diplomateacvs 《Veterinary surgery : VS》1986,15(4):329-333

An approach combining ventral midline celiotomy with transdiaphragmatic thoracotomy for permanent electronic cardiac pacemaker implantation was evaluated in seven dogs with bradycardia. Dogs ranged in body weight from 6.7 to 32 kg, with a mean of 22.2 ± 11.1 kg. Body conformation varied from narrow, deep-chested animals to very broad-chested animals. The new approach was used with equal facility in all of these dogs. Thoracocentesis was performed intraoperatively after diaphragmatic closure. No dogs required postoperative thoracocentesis or tube thoracostomy. All seven dogs survived the surgical procedure. Two dogs required three subsequent operations by the new approach for correction of exit block or faulty pulse generators. No problems were encountered during these reoperations, which occurred 2 days, 1 month, and 5 months, respectively, following the previous surgery. No serious complications attributable to the surgical approach were seen in any of the dogs, with follow-up times ranging from 6 hours to greater than 12 months (five dogs still alive). The transdiaphragmatic approach is a rapid, cosmetic, and subjectively less painful means for permanent pacemaker implantation in dogs.  相似文献   

RADIOGRAPHIC ASSESSMENT OF CRANIAL CRUCIATE LIGAMENT RUPTURE IN THE DAIRY COW     

JOHN C. HUHN  DVM    STEPHEN K. KNELLER  DVM  MS    DALE R. NELSON  DVM  MS 《Veterinary radiology & ultrasound》1986,27(6):184-188

Case records and radiographs of 37 dairy cows presented to the University of Illinois Veterinary Medicine Teaching Hospital with a diagnosis of cranial cruciate ligament rupture were reviewed. Signalment, history, duration of lameness prior to clinical presentation, and physical examination findings were evaluated. Survey radiographs were examined and radiographic lesions were documented. Individual cows were classified into groups (A, B, C) based on the severity of radiographic lesions, with Group A cows having minimal radiographic lesions. Cows in Groups A and B had radiographic lesions similar to Class I in beef bulls reported in another study.^3,4 An attempt was made to relate the severity of radiographic lesions with age and duration of lameness. Group A animals tended to be younger cows (x?= 4.58 years) with a short duration of lameness. Group B cows were older (x?= 7.87 years) with a somewhat longer duration of lameness. Group C cows were slightly younger (x?= 7.30 years) than Group B cows; however, their duration of lameness was much longer (x?= 57.2 weeks vs 6.35 weeks for Group B and 2.54 weeks for Group A). The pathogenesis of cranial cruciate ligament rupture and its associated lameness appeared to differ in dairy cows from beef bulls. The majority of animals in this study had radiographic lesions of mild to moderate severity (Groups A and B). In contrast, based on previous work, beef bulls had a greater tendency to be similar to our Group C designation. Beef bulls became lame with cranial cruciate ligament rupture only after severe lesions of degenerative joint disease had already occurred. It has been stated that lameness associated with cranial cruciate ligament rupture in the beef bull is, therefore, secondary to degenerative joint disease. In contrast, the syndrome in dairy cows, as evidenced here, differs, since they often presented with cranial cruciate ligament rupture with little or no radiographic evidence of degenerative joint disease.  相似文献   

Partial Invagination of the Canine Stomach for Treatment of Infarction of the Gastric Wall     

DOUGLAS M. MacCOY  dvm  Diplomateacvm  STEPHEN K. KNELLER dvm  Diplomateacvr  JOHN P. SUNDBERG dvm  PhD  Dipiomateacvp JOSEPH HARARI ms  dvm 《Veterinary surgery : VS》1986,15(3):237-245

A technique was evaluated for the management of infarction of a portion of the canine gastric fundus and body by invagination of the compromised gastric wall with a double layer of inverting sutures. Two methods of potentially producing vascular compromise of the gastic wall were developed and studied. In the first method (ten dogs plus three control dogs), the first three short gastric arteries and veins were ligated and divided; vascular compromise was not produced. In the second method (eight dogs), an area of the gastric fundus was isolated by a strangulating suture in addition to the division of the short gastric vessels; this method did produce vascular compromise. The invagination procedure caused melena for several days in four dogs. Complete healing of the gastric wall had not occurred at 2 weeks.  相似文献   

Fixation of the Deferent Ducts for Retrodisplacement of the Urinary Bladder and Prostate in Canine Perineal Hernia   总被引：1，自引：0，他引：1  

STEPHEN A. BILBREY DVM  MS    DANIEL D. SMEAK DVM  DiplomateACVs  WILLIAM DEHOFF DVM  MS  DiplomateACVs 《Veterinary surgery : VS》1990,19(1):24-27

The deferent ducts were secured to the lateral abdominal wall in nine dogs to correct retrodisplacement of the urinary bladder and prostate. Perineal herniorrhaphy and fixation of the deferent ducts were performed in seven dogs; in two dogs, only fixation of the deferent ducts was performed. All dogs were clinically normal after 4 to 28 months (mean, 14.7 months).  相似文献   

Veterinary Anaesthesia (9th edition) By L. W. Hall and K. W. Clarke     

STEPHEN A. GREENE 《Veterinary surgery : VS》1992,21(4):325-325

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Cortisol concentrations in blood and urine of horses     

J M RALSTON  A M STENHOUSE †  N S STENHOUSE‡  G J BUCK †  S. F. LUCKS †  J A REYNOLDSON  J R BOLTON 《Australian veterinary journal》1988,65(1):1-5

A survey of the concentrations of cortisol in blood and urine samples taken from thoroughbred and standardbred horses after racing is presented. Statistical analysis showed the only significant difference between thoroughbred and standardbred horses was a higher cortisol concentration in thoroughbred urine. Urine volume and pH had no significant influence on the urinary cortisol concentration, however 9.5% of the urinary cortisol variation could be explained due to the influence of plasma cortisol concentration. The results of cortisol and ACTH administrations are also shown and compared with the survey results.  相似文献