Outcomes and complications associated with ventral screws, pins, and polymethyl methacrylate for atlantoaxial instability in 12 dogs     

Sanders SG  Bagley RS  Silver GM  Moore M  Tucker RL 《Journal of the American Animal Hospital Association》2004,40(3):204-210

Clinical outcomes and complications of a technique used for atlantoaxial stabilization were evaluated in a group of 12 dogs. At surgery, the atlantoaxial joint was realigned and rigidly fixated using cortical bone screws, K-wire, and polymethyl methacrylate. Results in nine dogs were graded as excellent. Results in two dogs were judged as good. One dog was euthanized 17 months after surgery for recurrent cervical pain. Eight dogs had no postoperative complications. The surgical technique described provided an adaptable method for the correction of atlantoaxial instability.  相似文献   

Current research and theories on the pathogenesis of acute laminitis in the horse     

Bailey SR  Marr CM  Elliott J 《Veterinary journal (London, England : 1997)》2004,167(2):129-142

A large number of studies have been undertaken in recent years aimed at furthering our understanding of the complex mechanisms underlying the common and debilitating condition of acute laminitis in the horse. Many of these studies have either reinforced or cast doubt on previously held theories on the pathogenesis of this disease, while others have suggested new mechanisms which may play a key role in its development. This review seeks to put the current hypotheses into the context of this recent body of evidence. While a unifying theory may not yet seem to be achievable, this review demonstrates that most of the current theories are not mutually exclusive. Studies utilising in vitro and in vivo models of the disease, particularly addressing the areas of inflammation, haemodynamic disturbances and enzyme activation in the hoof, as well as the preceding events occurring in the hindgut, have helped to explain many clinical observations of the disease and may possibly lead to more effective therapies and means of prevention in the future.  相似文献   

Owner experiences and complications with home use of a replacement low profile gastrostomy device for long-term enteral feeding in dogs          下载免费PDF全文

Yoshimoto SK  Marks SL  Struble AL  Riel DL 《The Canadian veterinary journal. La revue veterinaire canadienne》2006,47(2):144-150

The purpose of this study was to evaluate complications and owner impressions of a low profile gastrostomy device (LPGD) for enteral feeding in dogs. Medical records of dogs that had placement of a percutaneous endoscopic gastrostomy tube followed by a LPGD between 1995 and 2003 were reviewed. Fifteen dogs had 29 devices placed for a variety of disease states in which enteral nutritional support was indicated. The individual tubes were placed for a median duration of 212 d. Most complications occurred more than 15 d after placement and were of no health risk to the animals. The most common reason for LPGD replacement was leakage through the 1-way antireflux valve. Fourteen of 15 owners that were contacted were supportive of the device. Based on its durability, ease of placement, minor complications, and positive owner impressions, we conclude that the LPGD is a valuable device for long-term enteral nutritional support of dogs.  相似文献   

The veterinary profession's role in policing animal welfare     

Whiting TL  Brennan SC  Wruck GC 《The Canadian veterinary journal. La revue veterinaire canadienne》2006,47(11):1065-1072

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Chocolate is a powerful ex vivo and in vivo antioxidant, an antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American Diets     

Vinson JA  Proch J  Bose P  Muchler S  Taffera P  Shuta D  Samman N  Agbor GA 《Journal of agricultural and food chemistry》2006,54(21):8071-8076

Chocolate today is often viewed as a food or snack with little nutritional value. The high saturated fat content of chocolate has also contributed to the belief that its consumption increases the risk of heart disease. However, recent human studies have proven that chocolate has beneficial effects on some pathogenic mechanisms of heart disease such as endothelial function and blood pressure. Although the antioxidant properties of chocolate have been known for some time, there has been no examination of its place in the U.S. diet as a source of antioxidants. This paper demonstrates that chocolate makes a significant contribution to U.S. per capita dietary antioxidants and by inference the European Community's. In the U.S. diet chocolate is the third highest daily per capita antioxidant source. An ex vivo study shows that epicatechin, a major polyphenol in chocolate and chocolate extracts, is a powerful inhibitor of plasma lipid oxidation due to polyphenols' ability to bind to lower density lipoproteins. Conversely, the fat from chocolate alone is a pro-oxidant in this model. This is also demonstrated in an in vivo human study. After consumption of dark chocolate and cocoa powder, the lower density lipoproteins isolated from plasma were protected from oxidation compared to the lipoproteins isolated after cocoa butter consumption, which were put under oxidative stress. In an animal model of atherosclerosis, cocoa powder at a human dose equivalent of two dark chocolate bars per day significantly inhibited atherosclerosis, lowered cholesterol, low-density lipoprotein, and triglycerides, raised high-density lipoprotein, and protected the lower density lipoproteins from oxidation. Chocolate has thus been shown to have potential beneficial effects with respect to heart disease.  相似文献   

Trade in wild birds     

Wensley S 《The Veterinary record》2006,159(9):292

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Complications and outcomes of one-step low-profile gastrostomy devices for long-term enteral feeding in dogs and cats     

Campbell SJ  Marks SL  Yoshimoto SK  Riel DL  Fascetti AJ 《Journal of the American Animal Hospital Association》2006,42(3):197-206

Sixteen dogs and cats with a variety of primary diseases were retrospectively evaluated following endoscopic placement of a one-step low-profile gastrostomy device. Overall, the devices were well tolerated, with most complications being minor in nature. Complications included bloody or purulent peristomal discharge, peristomal swelling, peristomal inflammation, discomfort associated with the device, leaking through the device, chewing at the device, premature removal of the device, peritonitis, and aspiration pneumonia. Dogs survived for up to 2241 days, and cats survived for up to 593 days after initial device placement. The median survival time after device insertion for dogs was 89 days, and for cats it was 87 days.  相似文献   

Topography of the northern hemisphere of Mercury from MESSENGER laser altimetry     

Zuber MT  Smith DE  Phillips RJ  Solomon SC  Neumann GA  Hauck SA  Peale SJ  Barnouin OS  Head JW  Johnson CL  Lemoine FG  Mazarico E  Sun X  Torrence MH  Freed AM  Klimczak C  Margot JL  Oberst J  Perry ME  McNutt RL  Balcerski JA  Michel N  Talpe MJ  Yang D 《Science (New York, N.Y.)》2012,336(6078):217-220

Laser altimetry by the MESSENGER spacecraft has yielded a topographic model of the northern hemisphere of Mercury. The dynamic range of elevations is considerably smaller than those of Mars or the Moon. The most prominent feature is an extensive lowland at high northern latitudes that hosts the volcanic northern plains. Within this lowland is a broad topographic rise that experienced uplift after plains emplacement. The interior of the 1500-km-diameter Caloris impact basin has been modified so that part of the basin floor now stands higher than the rim. The elevated portion of the floor of Caloris appears to be part of a quasi-linear rise that extends for approximately half the planetary circumference at mid-latitudes. Collectively, these features imply that long-wavelength changes to Mercury's topography occurred after the earliest phases of the planet's geological history.  相似文献   

Compartmentalized control of skin immunity by resident commensals     

S Naik  N Bouladoux  C Wilhelm  MJ Molloy  R Salcedo  W Kastenmuller  C Deming  M Quinones  L Koo  S Conlan  S Spencer  JA Hall  A Dzutsev  H Kong  DJ Campbell  G Trinchieri  JA Segre  Y Belkaid 《Science (New York, N.Y.)》2012,337(6098):1115-1119

Intestinal commensal bacteria induce protective and regulatory responses that maintain host-microbial mutualism. However, the contribution of tissue-resident commensals to immunity and inflammation at other barrier sites has not been addressed. We found that in mice, the skin microbiota have an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte function. Protective immunity to a cutaneous pathogen was found to be critically dependent on the skin microbiota but not the gut microbiota. Furthermore, skin commensals tuned the function of local T cells in a manner dependent on signaling downstream of the interleukin-1 receptor. These findings underscore the importance of the microbiota as a distinctive feature of tissue compartmentalization, and provide insight into mechanisms of immune system regulation by resident commensal niches in health and disease.  相似文献   

Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases   总被引：1，自引：0，他引：1  

Soon FF  Ng LM  Zhou XE  West GM  Kovach A  Tan MH  Suino-Powell KM  He Y  Xu Y  Chalmers MJ  Brunzelle JS  Zhang H  Yang H  Jiang H  Li J  Yong EL  Cutler S  Zhu JK  Griffin PR  Melcher K  Xu HE 《Science (New York, N.Y.)》2012,335(6064):85-88

Abscisic acid (ABA) is an essential hormone for plants to survive environmental stresses. At the center of the ABA signaling network is a subfamily of type 2C protein phosphatases (PP2Cs), which form exclusive interactions with ABA receptors and subfamily 2 Snfl-related kinase (SnRK2s). Here, we report a SnRK2-PP2C complex structure, which reveals marked similarity in PP2C recognition by SnRK2 and ABA receptors. In the complex, the kinase activation loop docks into the active site of PP2C, while the conserved ABA-sensing tryptophan of PP2C inserts into the kinase catalytic cleft, thus mimicking receptor-PP2C interactions. These structural results provide a simple mechanism that directly couples ABA binding to SnRK2 kinase activation and highlight a new paradigm of kinase-phosphatase regulation through mutual packing of their catalytic sites.  相似文献