Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. VIII. Conclusions and implications     

M W O'Callaghan  J R Pascoe  W S Tyler  D K Mason 《Equine veterinary journal》1987,19(5):428-434

This paper reviews a series of clinical, post mortem and imaging studies on exercise-induced pulmonary haemorrhage (EIPH) performed on 26 Thoroughbred racehorses. Post mortem techniques included routine gross, subgross and histological examination; coloured latex perfusions of pulmonary and bronchial circulations; and microradiography and computerised tomography scans of lungs with contrast injected vasculature. The major lesions were multiple, separate and coalescing foci of moderately proliferative small airway disease accompanied by intense neovascularisation of the bronchial circulation. As a result of bronchial artery angiogenesis, the systemic circulation dominated the vascular supply of the air exchange structures in affected areas, producing an apparent left to right shunt. Extensive areas of sequestered haemosiderophages indicated previous haemorrhage from vessels apparently supplied by the bronchial arteries. Diffuse and focal parenchymal destruction and connective tissue reactions in affected areas were considered to be secondary to localised haemorrhage and macrophage-induced damage. The aetiology of EIPH was not determined, but the multifocal, small airway-centred lesions indicated that low grade bronchiolitis, possibly of viral origin, was a factor. Gravitational effects also appear to contribute to dorsal distribution of the lesions. The mild focal and subclinical lesions confined to secondary lobules are thought to evolve into the serious lung pathology observed in EIPH cases through the effects of localised hypoxia induced by maximal exercise and partial airway obstruction. Once initiated, a vicious cycle of increasing inflammatory damage and further local bleeding is set in motion.  相似文献   

Exercise-induced pulmonary haemorrhage in the horse: results of a detailed clinical, post mortem and imaging study. III. Subgross findings in lungs subjected to latex perfusions of the bronchial and pulmonary arteries   总被引：1，自引：0，他引：1  

M W O'Callaghan  J R Pascoe  W S Tyler  D K Mason 《Equine veterinary journal》1987,19(5):394-404

Latex was injected under pressure into bronchial and pulmonary arteries of the inflated lungs of Thoroughbreds and transverse sections taken to calculate the area of lesions resulting from exercise-induced pulmonary haemorrhage. Extensive areas of dense brown haemosiderin varying from 0 to 45 per cent of total lung volume were identified, predominantly in the dorsocaudal lungfields. Bronchial arterial proliferation appeared to have replaced the pulmonary supply in affected areas of the lung. Closely associated with the staining and bronchial arterialisation, there was widespread small airway disease. The most severely affected bronchioles contained thick gelatinous or mucous exudate or mucoid plugs and had grossly thickened walls. These lesions suggest that the source of haemorrhage in exercise-induced pulmonary haemorrhage is from alveolar capillaries anomalously supplied by the bronchial arterial circulation through the development of pathological shunts. Small airway disease is suggested as being of major importance in the pathogenesis of the disease and may have led to the initial proliferation of the bronchial circulation.  相似文献   

Survival after small intestine resection and anastomosis in horses   总被引：3，自引：0，他引：3  

M H MacDonald  J R Pascoe  S M Stover  D M Meagher 《Veterinary surgery : VS》1989,18(6):415-423

The authors examined factors influencing survival in 140 horses that recovered from anesthesia after small intestinal resection between 1968 and 1986, using Kaplan-Meier estimated survival curves and the Cox proportional hazards regression model. Seventy-two horses (51%) died during the initial postoperative period, 19 horses (14%) died after discharge from the hospital, 33 horses (24%) were alive, and 16 horses (11%) were classified as censored. Mean age at surgery was 8 years. Horses 15 years of age or older, Arabians and Stallions, were overrepresented in the hospital population. The most common reason for resection was strangulation of bowel through a mesenteric rent. The mean and 50% median survival times were 1540 and 27 days, respectively. Horses admitted after January 1, 1980, had a significantly longer survival than those admitted before that time. Survival was longer after anastomosis of two small intestinal segments than after anastomosis of a small intestinal segment to the cecum; however, the length of bowel resected and the method of anastomosis had no demonstrable influence on survival. Of the variables studied, the heart rates at presentation and 24 hours after surgery were the most accurate predictors of survival.  相似文献   

The case for the routine use of analgesics.     

P J Pascoe 《Veterinary Clinics of North America: Small Animal Practice》1992,22(2):357-359

Surgery is painful and it behooves us, as people who care for and take care of animals, to prevent their suffering whenever possible. Recent developments in the understanding of nociceptive physiology underscores this prospective, rather than retrospective, approach to the management of pain. We have the armamentarium to do this and there are very few deleterious side effects when appropriate treatments are used.  相似文献   

COMPLICATIONS FOLLOWING A RUPTURED BLADDER IN A 60-DAY-OLD FOAL     

R. R. Pascoe  M.V.Sc.  F.R.C.V.S.  F.A.C.V.Sc. 《Australian veterinary journal》1976,52(10):473-475

The death of a 60-day-old foal due to massive haemorrhage associated with erosion of the left umbilical artery into the left ureter is reported. Surgical repair attempts are described together with post-mortem findings.  相似文献   

Persistence of Salmonella Typhimurium DT120 in abattoir paddocks holding sheep     

Purvis GM  Hullah K  Pascoe SJ  Evans SJ  Davies RH 《The Veterinary record》2005,157(6):165-167

In the summer of 1999 there was an outbreak of Salmonella Typhimurium DT120 in people in the north of England which was unusual in being sensitive to antimicrobial drugs. The outbreak was linked to mutton and lamb from a local abattoir, and attention focused on four holding paddocks used to retain sheep before slaughter. In November 1999, samples of soil and faeces were taken from these paddocks and samples of faeces were taken from the concrete race leading from them. Salmonella Typhimurium was isolated from 59 of the 100 samples. Between January 2000 and October 2000 seven visits were made to the abattoir at each of which 100 samples were taken from the paddocks and concrete race and examined for the presence of Salmonella. The paddocks remained heavily contaminated with S Typhimurium DT120 until April when there was a marked reduction in the recovery of the organism. By June the contamination was minimal and by August it had disappeared, and the organism was not recovered in September or October.  相似文献   

Somatostatin receptor imaging in vivo by planar scintigraphy facilitates the diagnosis of canine insulinomas     

Garden OA  Reubi JC  Dykes NL  Yeager AE  McDonough SP  Simpson KW 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(2):168-176

Somatostatin receptors expressed by insulinomas in 5 dogs were imaged in vivo by means of indium in 111 pentetreotide (OctreoScan) scintigraphy. The diagnosis in each dog was supported by the presence of hypoglycemia (<60 mg/dL), hyperinsulinemia (>20 microU/mL), and histopathologic review of neoplastic tissue. All insulinomas expressed high-affinity somatostatin receptors of subtype sst2, as shown by receptor autoradiography in vitro using 125I-[tyrosine3]-octreotide and 125I-[leucine8, Dtryptophan22, tyrosine25]-somatostatin-28 with an sst2 subtype-selective analogue. Scintigrams were obtained at 1, 4, 12, and 24 hours after the i.v. administration of 74-222 MBq of OctreoScan to each patient. Abnormal foci of activity were 1st observed from 1 hour after administration of the radioligand in dog 3, to 24 hours after its administration in dog 4; in dogs 1 and 2, abnormal foci of activity were visible from 12 hours. Dog 5 showed a questionable abnormal focus of activity at 12 hours, but not at 24 hours. Scintigraphy enabled accurate prediction of the anatomical location of the primary tumor in 1 of 4 dogs, but was unable to differentiate a right- from a left-pancreatic lobe tumor, or vice versa, in 3 dogs; the 5th dog had equivocal results. 111In-pentetreotide scintigraphy is a useful diagnostic adjunct to the clinical evaluation of the insulinoma patient, but is unable to localize the tumor in some cases.  相似文献   

Giant unruptured aneurysm of the left sinus of Valsalva in the left ventricular outflow tract of a young dog     

Jandrey KE  Smarick SD  Burkitt JM  Labelle P  Mohr FC  Kittleson MD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(4):602-605

A young adult, 28 kg, intact female Siberian husky-mixed breed dog was presented to the Veterinary Medical Teaching Hospital (VMTH) Emergency Service for evaluation of a dysrhythmia and an abnormal cardiac structure. The dog had been adopted from an animal shelter approximately 3 months before presentation. The dog occasionally showed exercise intolerance, and the owners suspected that she had impaired vision. Initial clinical signs appeared 2 days before presentation during strenuous activity—the dog uncharacteristically stopped and lay down while tachypneic. The dog produced dark liquid feces and was lethargic and anorexic overnight.  相似文献   

THE EPIDEMIOLOGY OF RINGWORM IN RACEHORSES CAUSED BY TRICHOPHYTON EQUINUM var AUTOTROPHICUM     

R. R. Pascoe 《Australian veterinary journal》1979,55(9):403-407

The epidemiology of dermatomycocis due to Trichophyton equinum var autotrophicum was studied in a number of thoroughbred stables in south-east Queensland. The significant factors in the epidemiology were defined. The infection was readily transmitted, particularly by infected saddle-girths, on which the fungus could survive for 12 months. Mild abrasion from the saddle during work favoured the development of lesions and prolonged the recovery period. A pronounced age and seasonal incidence of the disease was demonstrated as young horses under the age of 3 years were most susceptible, and the majority of cases occurred in periods of high humidity.  相似文献   

REPAIR OF A DEFECT IN THE BLADDER OF A FOAL   总被引：1，自引：0，他引：1  

R. R. Pascoe  M.V.Sc.  M.R.C.V.S. 《Australian veterinary journal》1971,47(7):343-344

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