Epidemiology and cost of Lyme disease‐related hospitalizations among patients with employer‐sponsored health insurance—United States, 2005–2014     

Amy M. Schwartz  Manjunath B. Shankar  Kiersten J. Kugeler  Ryan J. Max  Alison F. Hinckley  Martin I. Meltzer  Christina A. Nelson 《Zoonoses and public health》2020,67(4):407-415

An estimated 300,000 cases of Lyme disease occur in the United States annually. Disseminated Lyme disease may result in carditis, arthritis, facial palsy or meningitis, sometimes requiring hospitalization. We describe the epidemiology and cost of Lyme disease‐related hospitalizations. We analysed 2005–2014 data from the Truven Health Analytics MarketScan Commercial Claims and Encounters Databases to identify inpatient records associated with Lyme disease based on International Classification of Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) codes. We estimated the annual number and median cost of Lyme disease‐related hospitalizations in the United States in persons under 65 years of age. Costs were adjusted to reflect 2016 dollars. Of 20,983,165 admission records contained in the inpatient databases during the study period, 2,823 (0.01%) met inclusion criteria for Lyme disease‐related hospitalizations. Over half of the identified records contained an ICD‐9‐CM code for meningitis (n = 614), carditis (n = 429), facial palsy (n = 400) or arthritis (n = 377). Nearly 60% of hospitalized patients were male. The median cost per Lyme disease‐related hospitalization was $11,688 (range: $140–$323,613). The manifestation with the highest median cost per stay was carditis ($17,461), followed by meningitis ($15,177), arthritis ($13,012) and facial palsy ($10,491). Median cost was highest among the 15‐ to 19‐year‐old age group ($12,991). Admissions occurring in January had the highest median cost ($13,777) for all study years. Based on extrapolation to the U.S. population, we estimate that 2,196 Lyme disease‐related hospitalizations in persons under 65 years of age occur annually with an estimated annual cost of $25,826,237. Lyme disease is usually treated in an outpatient setting; however, some patients with Lyme disease require hospitalization, underscoring the need for effective prevention methods to mitigate these serious cases. Information from this analysis can aid economic evaluations of interventions that prevent infection and advances in disease detection.  相似文献   

Estimating Velocity for Processive Motor Proteins with Random Detachment     

John Hughes  Shankar Shastry  William O. Hancock  John Fricks 《Journal of Agricultural, Biological & Environmental Statistics》2013,18(2):204-217

We show that, for a wide range of models, the empirical velocity of processive motor proteins has a limiting Pearson type VII distribution with finite mean but infinite variance. We develop maximum likelihood inference for this Pearson type VII distribution. In two simulation studies, we compare the performance of our MLE with the performance of standard Student’s t-based inference. The studies show that incorrectly assuming normality (1) can lead to imprecise inference regarding motor velocity in the one-sample case, and (2) can significantly reduce power in the two-sample case. These results should be of interest to experimentalists who wish to engineer motors possessing specific functional characteristics.  相似文献   

Effect of nutrients and plant extracts on Alternaria blight of tomato caused by Alternaria Alternata     

Sharma  Ratan Lal  Ahir  R. R.  Yadav  Shankar Lal  Sharma  Pinki  Ghasolia  R. P. 《植物病害和植物保护杂志》2021,128(4):951-960

Journal of Plant Diseases and Protection - Studies with nutrients and phyto-extracts were performed in vitro and in vivo to assess their potential in controlling Alternaria blight of tomato...  相似文献   

Stability analysis for bollworm complex in <Emphasis Type="Italic">Gossypium hirsutum</Emphasis> L.     

Shankar Lal Ahuja  P. Jeyakumar  L. S. Dhayal 《Euphytica》2008,161(3):313-318

One approach to improve cotton (Gossypium hirsutum L.) yield is to identify stable genotypes for low or no bollworms damage as it accounts low cost of cultivation to a considerable extent. The objective of the study was to identify stable genotypes for low bollworms damage under protected and unprotected experiments. Fifty cotton (Gossypium hirsutum L.) genotypes were evaluated for open bollworms damage percent (spotted, pink and Heliothis bollworms) for 3 years during 2003–2005 under protected and unprotected conditions. Variance due to genotypes, environments, genotype × environment and genotype × environment (linear) components were highly significant for the trait in protected and unprotected experiments. Under protected experiment, genotypes CSH 3020 and 3045 were found to be desirable and stable while genotype CSH 3058 was suited for poor environments. Fourteen genotypes viz. CSH 3034, 3035, 3043, 3044, 3047, 3051, 3053, 3058, 3059, 3094, 3106, 3114, 3123 and CSH-3157 were fairly stable under unprotected environments. The study lead to the conclude that in general for the two experiments the genotypes differed for stability for low bollworms damage.  相似文献   

Rhizobacteria‐mediated resistance against the blackeye cowpea mosaic strain of bean common mosaic virus in cowpea (Vigna unguiculata)     

Arakere Chunchegowda Udaya Shankar  Siddaiah Chandra Nayaka  Sathyanarayana Niranjan‐Raj  Hanumanthaiah Bhuvanendra Kumar  Munagala S Reddy  Siddapura Ramachandrappa Niranjana  Harishchandra Sripathy Prakash 《Pest management science》2009,65(10):1059-1064

BACKGROUND: The present study investigated the effect of seven Bacillus‐species plant‐growth‐promoting rhizobacteria (PGPR) seed treatments on the induction of disease resistance in cowpea against mosaic disease caused by the blackeye cowpea mosaic strain of bean common mosaic virus (BCMV). RESULTS: Initially, although all PGPR strains recorded significant enhancement of seed germination and seedling vigour, GBO3 and T4 strains were very promising. In general, all strains gave reduced BCMV incidence compared with the non‐bacterised control, both under screen‐house and under field conditions. Cowpea seeds treated with Bacillus pumilus (T4) and Bacillus subtilis (GBO3) strains offered protection of 42 and 41% against BCMV under screen‐house conditions. Under field conditions, strain GBO3 offered 34% protection against BCMV. The protection offered by PGPR strains against BCMV was evaluated by indirect enzyme‐linked immunosorbent assay (ELISA), with lowest immunoreactive values recorded in cowpea seeds treated with strains GBO3 and T4 in comparison with the non‐bacterised control. In addition, it was observed that strain combination worked better in inducing resistance than individual strains. Cowpea seeds treated with a combination of strains GBO3 + T4 registered the highest protection against BCMV. CONCLUSION: PGPR strains were effective in protecting cowpea plants against BCMV under both screen‐house and field conditions by inducing resistance against the virus. Thus, it is proposed that PGPR strains, particularly GBO3, could be potential inducers against BCMV and growth enhancers in cowpea. Copyright © 2009 Society of Chemical Industry  相似文献   

Premature seed germination induced by very-long-chain fatty acids causes jelly seed disorder in the mango (Mangifera indica L.) cultivar ‘Amrapali’ in India     

Seshadri Shivashankar  Manoharan Sumathi  Hari Shankar Singh 《The Journal of Horticultural Science and Biotechnology》2016,91(2):138-147

Jelly seed (JS) in ‘Amrapali’ mango (Mangifera indica L.) is a physiological disorder, the cause of which has long remained obscure. The disorder is distinguished by the appearance of jelly-like tissue in the pulp adjoining the stone, although the fruit show no external symptoms. The objective of this study was to determine the causative factor inducing the JS disorder in ‘Amrapali’ mango. Studies showed, for the first time, that JS in ‘Amrapali’ mango arose at the start of germination-associated events in the seed of developing fruit. The trigger for premature seed germination originated from reduced synthesis of very-long-chain fatty acids (VLCFAs) in the seed of developing fruit. This then promoted the production of cytokinins, leading to the onset of premature germination-associated events in the seed. Consequently, a large increase in the activities of pectinolytic enzymes in JS pulp occurred that led to the rapid degradation of pectin and excessive softening of the pulp, to the consistency of jelly. The application of plant growth regulators to developing fruit showed that gibberellic acid (GA₃) increased the incidence of JS, while paclobutrazol reduced the incidence of JS, confirming that the onset of early germination during fruit maturation and ripening played a primary role in the incidence of the JS disorder.  相似文献   

Breast-feeding initiation and determinants of exclusive breast-feeding - a questionnaire survey in an urban population of western Nepal     

Chandrashekhar TS  Joshi HS  Binu V  Shankar PR  Rana MS  Ramachandran U 《Public health nutrition》2007,10(2):192-197

OBJECTIVE: To assess rates of initiation of breast-feeding and exclusive breast-feeding within 2 months after delivery and to determine the factors influencing exclusive breast-feeding. DESIGN: A health worker-administered questionnaire survey was carried out during the time period 1 August-30 September 2005. SETTING: Immunisation clinics of Pokhara, a submetropolitan city in western Nepal. SUBJECTS: Three hundred and eighty-five mothers who had delivered a child within the previous 2 months. RESULTS: The rates of initiation within 1 h and within 24 h of delivery were 72.7 and 84.4%, respectively. Within 2 months after delivery, exclusive breast-feeding was practised by 82.3% of the mothers. Breast milk/colostrum was given as the first feed to 332 (86.2%) babies but 17.2% of them were either given expressed breast milk or were put to the breast of another lactating mother. Pre-lacteal feeds were given to 14% of the babies. The common pre-lacteal feeds given were formula feeds (6.2%), sugar water (5.9%) and cow's milk (2.8%). Complementary feeds were introduced by 12.7% of the mothers. By logistic regression analysis, friends' feeding practices, type of delivery and baby's first feed were the factors influencing exclusive breast-feeding practice of the mothers. CONCLUSIONS: Despite the higher rates of initiation and exclusive breast-feeding, practices such as pre-lacteal feeds and premature introduction of complementary feeds are of great concern in this urban population. There is a need for promotion of good breast-feeding practices among expectant mothers and also the community, especially the families, taking into account the local traditions and customs.  相似文献   

Immunostimulating influence of herbal biomedicines on nonspecific immunity in Grouper Epinephelus tauvina juvenile against Vibrio harveyi infection   总被引：1，自引：0，他引：1  

S. M. J. Punitha  M. M. Babu  V. Sivaram  V. S. Shankar  S. A. Dhas  T. C. Mahesh  G. Immanuel  T. Citarasu 《Aquaculture International》2008,16(6):511-523

Herbals such as Cynodon dactylon, Piper longum, Phyllanthus niruri, Tridax procumbens, and Zingiber officinalis were extracted with acetone, benzene, butanol, and petroleum ether and screened against the pathogen Vibrio harveyi isolated from the infected Grouper Epinephalus tauvina. Among the different solvent extractions screening to V. harveyi, petroleum ether extracts were suppressed significantly (P < 0.05). Equal proportions of the all-plant extracts were mixed with the artificial feeds at concentrations of 100, 200, 400, and 800 mg kg⁻¹ of diet and fed to grouper juveniles of 20 ± 2 g average weight for a period of 60 days. Every 20 days, fish juveniles were challenged with V. harveyi and the immune response was studied. The herbal diets significantly (P < 0.05) increased the survival, growth, and immune responses compared to the control group. The herbal diets were significantly improved (P < 0.01) in immune parameters such as phagocytic activity and albumin–globulin (A–G) ratio. Among the different concentrations of the herbals in the diet, the 400 mg kg⁻¹ diet was the most effective in the experiment.  相似文献   

Anti-oxidant status in embryonic,post-hatch and larval stages of Asian seabass (<Emphasis Type="Italic">Lates calcarifer</Emphasis>)   总被引：1，自引：0，他引：1  

Kalaimani N  Chakravarthy N  Shanmugham R  Thirunavukkarasu AR  Alavandi SV  Santiago TC 《Fish physiology and biochemistry》2008,34(2):151-158

The concentrations of anti-oxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and selenium-dependent glutathione peroxidase (SeGPx), and low molecular weight free-radical scavengers such as reduced glutathione (GSH) and ascorbic acid (vitamin C) were evaluated during the period from gastrulation (GS) to 25 days post-hatch (dph) in the larvae of Asian Seabass, Lates calcarifer. Oxidative damage due to lipid peroxidation (LPO) was also assessed, by evaluation of the formation of malondialdehyde (MDA). All the three anti-oxidant enzymes, SOD, CAT and GPx, showed high activities during gastrulation, suggesting an increased metabolic rate during the period of embryonic development. Though the SOD activity apparently decreased progressively during 3–20 dph of larval development, the difference was not significant. CAT showed high activity during gastrulation and remained constant up to 3 dph, suggesting an increased need to metabolise hydrogen peroxide (H₂O₂) and organic peroxides. In contrast, SeGPx activity increased progressively from 5 dph to 25 dph during larval development, indicating an increased need to detoxify lipid peroxides. This is evident from the observation of increased lipid peroxidation from 10 dph to 25 dph during larval development. GSH levels were low at gastrulation, indicating increased metabolic rate and formation of lipid radicals during this period, corresponding to the decrease in the level of ascorbic acid, which is consumed for regeneration of GSH.  相似文献   

Prevalence of Multi-Drug-Resistant Salmonella in Equids Maintained by Low Income Individuals and on Designated Equine Farms in India     

B.R. Singh PhD  N. Babu MVSc  J. Jyoti MVSc  H. Shankar PhD  T.V. Vijo BVSc  AH  R.K. Agrawal PhD  M. Chandra PhD  D. Kumar MVSc  A. Teewari MVSc 《Journal of Equine Veterinary Science》2007,27(6):266-276

We examined 872 equids (445 maintained by low-income individuals and 427 maintained on nine designated equine farms) and, using previously described methods for bacteria, isolated Salmonella from fecal samples of 59 (6.77%) animals. Of the 646 horses, 183 donkeys, and 43 mules that had feces cultured for Salmonella, 42 (6.5%), 7 (3.8%), and 10 (23.3%), respectively, were excreting Salmonella strains in feces. Six horse mares were excreting Salmonella enterica of two different serovars simultaneously. A total of 65 Salmonella enterica isolates belonged to 13 serovars, namely S. paratyphi B var Java (14), S. I. 4, 5, 12, 27: r, i: 1, 5 (11), S. Drogana (8), S. Newport (7), S. Saintpaul (5), S. Lagos (4), S. Typhimurium (5), S. Kottbus (3), S. Bovismorbificans (3), S. Dumfries (2), S. Tshiongwe (1) S. Weltevreden (monophasic) (1), and S. enterica ssp salamae (1). With Salmonella-specific polymerase chain reaction (PCR) using hisJ gene primers, 107 (12.3) fecal samples yielded a specific amplicon of 496 bp. On using PCR, prevalence of Salmonella in donkeys, horses, and mules was 4.9%, 10.8%, and 65.1%, respectively. With both methods of Salmonella detection in feces, prevalence was significantly higher in female than in male donkeys and horses. Salmonella shedding in feces was significantly higher in equids maintained by low-income people than those at designated equine farms. Almost all Salmonella isolates (63 of 65) had multiple-drug-resistance (MDR, resistance to three or more drugs). Salmonella isolates were commonly resistant to sulfamethoxazole (90.8%), tetracycline (70.8%), doxycycline (67.7%), furazolidone (66.2%), and colistin (55.4%). A few isolates had resistance to trimethoprim (3.1%), ciprofloxacin (3.1%), ceftriaxone (3.1%), ceftazidime (3.1%), cefoperazone (3.1%), chloramphenicol (4.6%), cefotaxime (6.2%), gentamicin (9.2%), ampicillin + cloxacillin (9.2%), cotrimoxazole (13.8%), kanamycin (13.8%), amoxicillin + clavulanic acid (16.9%), imipenem (16.9%), ampicillin (18.5%), amikacin (23.1%), neomycin (27.7%), nalidixic acid (33.8%), and streptomycin (36.9%). With the exception of 13 Salmonella isolates of S. Drogana (4), S. Newport (4), S. I. 4, 5, 12, 27: r, i: 1, 5 (4) and S. Kottbus (1) serovars, all had one or more than one plasmid. Molecular weight of plasmids ranged between 3 kDa and >87 kDa. One heavy plasmid (≥87 kda) was present in all the 52 plasmid-positive strains. Presence of plasmid could not be correlated with MDR in Salmonella isolates from equids.  相似文献