Abbau des Herbizids Chloralhydrat im Boden     

H. R. Schütte  U. Stephan 《植物养料与土壤学杂志》1969,123(3):212-219

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Germline allele-specific expression of TGFBR1 confers an increased risk of colorectal cancer     

Valle L  Serena-Acedo T  Liyanarachchi S  Hampel H  Comeras I  Li Z  Zeng Q  Zhang HT  Pennison MJ  Sadim M  Pasche B  Tanner SM  de la Chapelle A 《Science (New York, N.Y.)》2008,321(5894):1361-1365

Much of the genetic predisposition to colorectal cancer (CRC) in humans is unexplained. Studying a Caucasian-dominated population in the United States, we showed that germline allele-specific expression (ASE) of the gene encoding transforming growth factor-beta (TGF-beta) type I receptor, TGFBR1, is a quantitative trait that occurs in 10 to 20% of CRC patients and 1 to 3% of controls. ASE results in reduced expression of the gene, is dominantly inherited, segregates in families, and occurs in sporadic CRC cases. Although subtle, the reduction in constitutive TGFBR1 expression alters SMAD-mediated TGF-beta signaling. Two major TGFBR1 haplotypes are predominant among ASE cases, which suggests ancestral mutations, but causative germline changes have not been identified. Conservative estimates suggest that ASE confers a substantially increased risk of CRC (odds ratio, 8.7; 95% confidence interval, 2.6 to 29.1), but these estimates require confirmation and will probably show ethnic differences.  相似文献   

CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance   总被引：3，自引：0，他引：3  

Niess JH  Brand S  Gu X  Landsman L  Jung S  McCormick BA  Vyas JM  Boes M  Ploegh HL  Fox JG  Littman DR  Reinecker HC 《Science (New York, N.Y.)》2005,307(5707):254-258

Dendritic cells (DCs) and macrophages are critical to innate and adaptive immunity to the intestinal bacterial microbiota. Here, we identify a myeloid-derived mucosal DC in mice, which populates the entire lamina propria of the small intestine. Lamina propria DCs were found to depend on the chemokine receptor CX3CR1 to form transepithelial dendrites, which enable the cells to directly sample luminal antigens. CX3CR1 was also found to control the clearance of entero-invasive pathogens by DCs. Thus, CX3CR1-dependent processes, which control host interactions of specialized DCs with commensal and pathogenic bacteria, may regulate immunological tolerance and inflammation.  相似文献   

5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia     

Manzke T  Guenther U  Ponimaskin EG  Haller M  Dutschmann M  Schwarzacher S  Richter DW 《Science (New York, N.Y.)》2003,301(5630):226-229

Opiates are widely used analgesics in anesthesiology, but they have serious adverse effects such as depression of breathing. This is caused by direct inhibition of rhythm-generating respiratory neurons in the Pre-Boetzinger complex (PBC) of the brainstem. We report that serotonin 4(a) [5-HT4(a)] receptors are strongly expressed in respiratory PBC neurons and that their selective activation protects spontaneous respiratory activity. Treatment of rats with a 5-HT4 receptor-specific agonist overcame fentanyl-induced respiratory depression and reestablished stable respiratory rhythm without loss of fentanyl's analgesic effect. These findings imply the prospect of a fine-tuned recovery from opioid-induced respiratory depression, through adjustment of intracellular adenosine 3',5'-monophosphate levels through the convergent signaling pathways in neurons.  相似文献   

A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective     

Rendulic S  Jagtap P  Rosinus A  Eppinger M  Baar C  Lanz C  Keller H  Lambert C  Evans KJ  Goesmann A  Meyer F  Sockett RE  Schuster SC 《Science (New York, N.Y.)》2004,303(5658):689-692

Predatory bacteria remain molecularly enigmatic, despite their presence in many microbial communities. Here we report the complete genome of Bdellovibrio bacteriovorus HD100, a predatory Gram-negative bacterium that invades and consumes other Gram-negative bacteria. Its surprisingly large genome shows no evidence of recent gene transfer from its prey. A plethora of paralogous gene families coding for enzymes, such as hydrolases and transporters, are used throughout the life cycle of B. bacteriovorus for prey entry, prey killing, and the uptake of complex molecules.  相似文献   

The chemistry of sexual deception in an orchid-wasp pollination system     

Schiestl FP  Peakall R  Mant JG  Ibarra F  Schulz C  Franke S  Francke W 《Science (New York, N.Y.)》2003,302(5644):437-438

The "sexually deceptive" orchid Chiloglottis trapeziformis attracts males of its pollinator species, the thynnine wasp Neozeleboria cryptoides, by emitting a unique volatile compound, 2-ethyl-5-propylcyclohexan-1,3-dione, which is also produced by female wasps as a male-attracting sex pheromone.  相似文献   

Carbon flux and growth in mature deciduous forest trees exposed to elevated CO2   总被引：1，自引：0，他引：1  

Körner C  Asshoff R  Bignucolo O  Hättenschwiler S  Keel SG  Peláez-Riedl S  Pepin S  Siegwolf RT  Zotz G 《Science (New York, N.Y.)》2005,309(5739):1360-1362

Whether rising atmospheric carbon dioxide (CO2) concentrations will cause forests to grow faster and store more carbon is an open question. Using free air CO2 release in combination with a canopy crane, we found an immediate and sustained enhancement of carbon flux through 35-meter-tall temperate forest trees when exposed to elevated CO2. However, there was no overall stimulation in stem growth and leaf litter production after 4 years. Photosynthetic capacity was not reduced, leaf chemistry changes were minor, and tree species differed in their responses. Although growing vigorously, these trees did not accrete more biomass carbon in stems in response to elevated CO2, thus challenging projections of growth responses derived from tests with smaller trees.  相似文献   

Infrared echoes near the supernova remnant Cassiopeia A     

Krause O  Rieke GH  Birkmann SM  Le Floc'h E  Gordon KD  Egami E  Bieging J  Hughes JP  Young ET  Hinz JL  Quanz SP  Hines DC 《Science (New York, N.Y.)》2005,308(5728):1604-1606

Two images of Cassiopeia A obtained at 24 micrometers with the Spitzer Space Telescope over a 1-year time interval show moving structures outside the shell of the supernova remnant to a distance of more than 20 arc minutes. Individual features exhibit apparent motions of 10 to 20 arc seconds per year, independently confirmed by near-infrared observations. The observed tangential velocities are at roughly the speed of light. It is likely that the moving structures are infrared echoes, in which interstellar dust is heated by the explosion and by flares from the compact object near the center of the remnant.  相似文献   

Modern cyanobacterial analogs of paleozoic stromatoporoids     

Kazacutemierczak J  Kempe S 《Science (New York, N.Y.)》1990,250(4985):1244-1248

Recent and subfossil calcareous structures resembling cystose and subclathrate Paleozoic stromatoporoids have been discovered in a sea-linked, stratified, alkaline crater lake on Satonda Island, Indonesia. The structures are produced by mats of coccoid cyanobacteria growing along the lakeshore from the water surface down to the O(2)-H(2)S interface located at a depth of 22.8 meters. Calcification of the mats is controlled by seasonal changes in calcium carbonate supersaturation in the epilimnion. The internally complex structures are a product of two different calcification processes: (i) periodic in vivo calcification of the surficial cyanobacterial layers by low-Mg calcite, and (ii) early postmortem calcification of the cyanobacterial aggregates below the mat surface by microbially precipitated aragonite. The finding supports the idea that Paleozoic stromatoporoids represent fossilized cyanobacteria (stromatolites). It also implies that the stromatoporoid-generating epicontinental seas during the early Paleozoic may have been more alkaline and had a higher carbonate mineral supersaturation than modern seawater.  相似文献   

Economics. Can integration tame conflicts?     

Goette L  Meier S 《Science (New York, N.Y.)》2011,334(6061):1356-1357

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