Bioavailability of two ibuprofen oral paste formulations in fed or nonfed ponies.     

G M Vandenbossche  S Bouckaert  C De Muynck  G Mommens  A Van Zeveren  J P Remon 《American journal of veterinary research》1992,53(4):528-531

The bioavailability and pharmacokinetics of ibuprofen, a nonsteroidal antiinflammatory drug, was studied in healthy Shetland ponies. Ibuprofen was administered IV, as a suspension, and as a solid solution oral paste to ponies from which food was withheld. The suspension paste was also administered to ponies that received hay and water ad libitum. Both formulations had an absolute bioavailability of about 80%. Bioavailability was not influenced by feeding.  相似文献   

Growth and abortion of flower buds in gynoecious cucumber plants in relation to temperature     

Johanna L.F. Van Der Vlugt 《Scientia Horticulturae》1983,20(4):329-339

The growth of flower buds in a gynoecious cucumber cultivar was studied at 15, 21 and 27°C. Competition between buds in the same node was measured as the ratio of the growth rates of individual buds. This competition was stronger at 21 and 27 than at 15°C. At 15°C, at least 3 buds were about equally strong; at 21°C, 2 buds developed fast and suppressed the other buds; at 27°C, the first bud which developed suppressed all other buds. When plants were transferred from one temperature to another, the growth-rate ratio between buds in older nodes was maintained. In nodes formed in the new temperature regime, the growth-rate ratio was determined by the new temperature.  相似文献   

Comparison of three enzyme-linked immunosorbent assays for serologic diagnosis of contagious agalactia in sheep.     

Michel Pépin  Philippe Dufour  Maurice Lambert  Michel Aubert  Aurèle Valognes  Thierry Rotis  Anne Van de Wiele  Dominique Bergonier 《Journal of veterinary diagnostic investigation》2003,15(3):281-285

Serologic diagnosis of ovine contagious agalactia (Mycoplasma agalactiae) with the enzyme-linked immunosorbent assay (ELISA) developed by Agence Fran?aise de Sécurité Sanitaire des Aliments (AFSSA) may produce a few false-positive (FP) and false-negative (FN) results. When the prevalence of disease is low, these erroneous results may generate problems for eradication schemes. To prevent this, 2 commercial ELISAs were compared with the AFSSA ELISA. Flocks of known status were selected and classified into 4 categories: true positive (TP), FP, true negative (TN), and FN; 20 sheep per flock were submitted for blood sampling. A flock was considered positive when at least 1 out of 20 sera was positive or 2 sera were doubtful. In the flock, the diagnostic sensitivity of the 3 kits was very good (100%), and the diagnostic specificity showed an improvement from 46% (AFSSA test) to 88% and 92% (commercial tests). Considering individual animals, very few positive ewes were detected within TN or FP flocks; the proportion of positive ewes varied greatly from one kit to another (48% to 82%) within TP flocks. The kinetics of antibody response in sheep experimentally infected with various field strains of M. agalactiae were quite similar with all 3 ELISAs. The agreement between the 3 tests, assessed using the kappa value, varied from moderate to good (respective values of 0.56, 0.61, and 0.86). The 2 commercial ELISAs showed better performances, probably because of a superior analytical sensitivity, and are a good alternative for the serodiagnosis of contagious agalactia in sheep.  相似文献   

Anthelmintic efficacy of flubendazole paste against nematodes and cestodes in dogs and cats     

O Vanparijs  L Hermans  L Van der Flaes 《American journal of veterinary research》1985,46(12):2539-2541

Small dogs and cats, naturally infected with nematodes and cestodes, were used in a critical test under laboratory conditions to determine the palatability and efficacy of flubendazole as a past formulation. Subsequently, a control test in dogs was conducted under field conditions. A 4.4% past formulation was given at a dosage of 22 mg/kg of body weight once a day for 2 or 3 consecutive days. In a critical test in dogs, the efficacy against Toxocara canis was 97.4% after a 2-day administration and 100% after 3 days. Toxascaris leonina seemed to be the most susceptible worm species, since either 2 or 3 treatments were 100% active. The efficacy against Uncinaria stenocephala was 97.5% after 2 treatments; the same dose level for 3 days improved the efficacy to 100%. The efficacy was 100% for the removal of Trichuris vulpis after a daily dosage for 2 days and 96.7% after 3 days. One of 2 dogs infected with Taenia pisiformis was cleared of the infection after a 2-day treatment, and 3 of 4 dogs were cleared after a 3-day regimen. All cats were cleared of Toxocara cati after 2 or 3 days of treatment. One of 2 cats infected with Hydatigera taeniaeformis was cleared of the infection after a 2-day treatment; a 3-day treatment in 7 cats was 100% effective. The results in the laboratory test in dogs were confirmed under field conditions by a control test, based on the reduction of eggs per gram of feces count after treatment. The paste formulation was well accepted by all dogs and cats without any side effects.  相似文献   

Veterinary herd health and production service on dairy farms IV. Index list on calf rearing and cow culling     

J.P.T.M. Noordhuizen  G.K. Van Meurs  R.K. Braun  A. Brand 《Preventive veterinary medicine》1985,3(3):277-287

The Herd Health and Production Service program for use in veterinary dairy practice is comprised of a basic and a flexible system. The basic system is a uniform system of data recording, standard veterinary activities and problem detection. In problem detection 4 index lists play a key role. The 4 comprise of the parameters or index figures that are relevant in monitoring the efficiency of milk production, calf rearing and cow replacement. Data on milk production, health status and reproduction of both individual animals and the herd are collected by the farmer and the veterinarian and transformed into index figures.This paper introduces index list “3”, with index figures for the monitoring of calf rearing and cow culling as parts of a herd health program. The development, implementation and significance of the index figures are presented. The index figures serve to detect unsatisfactory farm situations or problems in calf rearing and in cow culling. They trigger further investigation and aid the solution to and prevention of problems. Relationships with farm parameters mentioned in other index lists are also considered. Objectives and reference values where applicable are provided.  相似文献   

A net carbohydrate and protein system for evaluating cattle diets: III. Cattle requirements and diet adequacy.     

D G Fox  C J Sniffen  J D O'Connor  J B Russell  P J Van Soest 《Journal of animal science》1992,70(11):3578-3596

The Cornell Net Carbohydrate and Protein System (CNCPS) has equations for predicting nutrient requirements, feed intake, and feed utilization over wide variations in cattle (frame size, body condition, and stage of growth), feed carbohydrate and protein fractions and their digestion and passage rates, and environmental conditions. Independent data were used to validate the ability of the CNCPS to predict responses compared to National Research Council (NRC) systems. With DMI in steers, the CNCPS had a 12% lower standard error of the Y estimate (Sy.x) and three percentage units less bias than the NRC system. For DMI in heifers, both systems had a similar Sy.x but the NRC had four percentage units less bias. With lactating dairy cows' DMI, the CNCPS had a 12% lower Sy.x. Observed NEm requirement averaged 5% under NRC and 6% under CNCPS predicted values at temperatures above 9 degrees C but were 18% over NRC and 9% under CNCPS at temperatures under 9 degrees C. Energy retained was predicted with an R2 of .80 and .95 and a bias of 8 and 4% for the NRC and CNCPS, respectively. Protein retained was predicted with an R2 of .75 and .85 with a bias of 0 and -1% for NRC and CNCPS, respectively. Biases due to frame size, implant, or NEg were small. Body condition scores predicted body fat percentage in dairy cows with an R2 of .93 and a Sy.x of 2.35% body fat. The CNCPS predicted metabolizable protein allowable ADG with a bias of 1.6% with a Sy.x of .07 kg compared to values of -30% and .10 kg, respectively for the NRC system.  相似文献   

A net carbohydrate and protein system for evaluating cattle diets: I. Ruminal fermentation.   总被引：28，自引：0，他引：28  

J B Russell  J D O'Connor  D G Fox  P J Van Soest  C J Sniffen 《Journal of animal science》1992,70(11):3551-3561

The Cornell Net Carbohydrate and Protein System (CNCPS) has a kinetic submodel that predicts ruminal fermentation. The ruminal microbial population is divided into bacteria that ferment structural carbohydrate (SC) and those that ferment nonstructural carbohydrate (NSC). Protozoa are accommodated by a decrease in the theoretical maximum growth yield (.50 vs .40 g of cells per gram of carbohydrate fermented), and the yields are adjusted for maintenance requirements (.05 vs .150 g of cell dry weight per gram of carbohydrate fermented per hour for SC and NSC bacteria, respectively). Bacterial yield is decreased when forage NDF is < 20% (2.5% for every 1% decrease in NDF). The SC bacteria utilize only ammonia as a N source, but the NSC bacteria can utilize either ammonia or peptides. The yield of NSC bacteria is enhanced by as much as 18.7% when proteins or peptides are available. The NSC bacteria produce less ammonia when the carbohydrate fermentation (growth) rate is rapid, but 34% of the ammonia production is insensitive to the rate of carbohydrate fermentation. Ammonia production rates are moderated by the rate of peptide and amino acid uptake (.07 g of peptide per gram of cells per hour), and peptides and amino acids can pass out of the rumen if the rate of proteolysis is faster than the rate of peptide utilization. The protein-sparing effect of ionophores is accommodated by decreasing the rate of peptide uptake by 34%. Validation with published data of microbial flow from the rumen gave a regression with a slope of .94 and an r2 of .88.  相似文献   

Rapid in‐house method of CSF analysis utilising sedimentation direct from the spinal needle     

C. Hare  L. Sanchini  C. Worrall  S. Van Poucke  L. Alves  O. Restif  P. Freeman 《The Journal of small animal practice》2019,60(8):486-492

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Severe soft tissue infections in dogs: 47 cases (1996–2006)     

Yekaterina Buriko  Thomas J. Van Winkle  Kenneth J. Drobatz  Shelley C. Rankin  Rebecca S. Syring 《Journal of Veterinary Emergency and Critical Care》2008,18(6):608-618

Objective– To describe the patient population, microbiological findings, treatment and outcome in dogs with severe soft tissue infections (SSTIs) and to compare survivors to nonsurvivors. Design– Retrospective study. Animals– Forty‐seven dogs with confirmed soft tissue infections originating from the SC tissues, muscle or fascia. Interventions– None. Measurements and Main Results– Physical and clinicopathologic data on presentation, microbiological and histopathological findings, antimicrobial treatment and outcome. Dogs with SSTIs were predominantly large breed dogs with a median body weight of 35.6 kg. Incidence of pre‐existing conditions (immunomodulating diseases, blunt trauma, injections, clean surgical procedures) that could have contributed to development of SSTIs was 34%. Abnormal physical examination and diagnostic parameters on presentation included increased body temperature (median temperature 39.5 °C [103.1 °F]) and low arterial blood pressure (median systolic blood pressure 103.5 mm Hg). While Streptococcus species were the most commonly isolated bacteria, the incidence of polymicrobial infections differed between antemortem (38.7%) and postmortem (57.1%) cultures. The overall survival rate was 46.8%. Survivors had a higher body weight and higher respiratory rate on presentation than nonsurvivors. Nonsurvivors had a significantly lower WBC count and higher lactate, BUN, aspartate aminotransferase, and bilirubin concentrations. Histopathologic examination of tissue specimens showed that the degree of necrosis was higher in survivors compared with nonsurvivors. Conclusions– SSTIs in dogs are serious conditions associated with high mortality, significant inflammatory changes, and cardiovascular compromise. A number of conditions, including those that compromise skin integrity and immunomodulating diseases have been identified in our patient population and could have contributed to development of SSTIs. Polymicrobial infections occurred in many cases, necessitating broad‐spectrum antimicrobial coverage.  相似文献   

Presence of chlorogenic acid during in vitro maturation protects porcine oocytes from the negative effects of heat stress     

Thanh‐Van Nguyen  Lanh Thi Kim Do  Tamas Somfai  Takeshige Otoi  Masayasu Taniguchi  Kazuhiro Kikuchi 《Animal Science Journal》2019,90(12):1530-1536

Chlorogenic acid (CGA) is known to protect oocytes from oxidative stress. Here we investigated the effects of CGA on porcine oocyte maturation under heat stress and subsequent embryonic development after parthenogenetic activation. For in vitro maturation (IVM) at 41.0°C (hyperthermic condition), supplementation of the maturation medium with 50 μM CGA significantly improved the percentage of matured oocytes and reduced the rate of apoptosis relative to oocytes matured without CGA (p < .05). CGA treatment of oocytes during IVM under hyperthermia tended to increase (p < .1) percentage of blastocyst formation after parthenogenesis and significantly increased (p < .05) the total cell number per blastocyst relative to oocytes matured without CGA. For IVM at 38.5°C (isothermic condition), CGA significantly improved the rate of blastocyst development compared with oocytes matured without CGA (p < .05), but did not affect oocyte maturation, apoptosis rate or the number of cells per embryo. Omission of all antioxidants from the IVM medium significantly reduced the rate of oocyte maturation, but the rate was restored upon addition of CGA. These results demonstrate that CGA is a potent antioxidant that protects porcine oocytes from the negative effects of heat stress, thus reducing the frequency of apoptosis and improving the quality of embryos.  相似文献