Clinical Signs of Tumors Affecting the Rostral Cerebrum in 43 Dogs   总被引：2，自引：1，他引：1  

Ellen S. Foster DVM    Joseph M. Carrillo DVM  Amiya K. Patnaik DVM 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1988,2(2):71-74

The clinical and pathologic features of 43 dogs with neoplasia of the rostral cerebrum were reviewed. Primary brain tumors included meningioma, astrocytoma, neuroblastoma, oligodendroglioma, and ependymoma. Other tumors that secondarily affected these areas included solitary hemangiosarcoma, nasal neuroendocrine carcinoma, nasal cell adenocarcinoma, nasal squamous cell carcinoma, and nasal neurofibrosarcoma. Older dogs were usually affected (mean, 10 years), and meningioma was the most frequent tumor type. Thirty-one dogs (72% of total) had a late-onset (greater than 5 years of age) of either generalized seizures or behavior abnormalities, or both, with an initially normal neurologic examination. In these 31 dogs, a mean time of 78 days (range, 2 to 400 days) elapsed from the onset of seizures or behavior change to the detection of a persistently abnormal neurologic examination. In all 43 dogs, the time from the detection of neurologic deficits to death or euthanasia and necropsy ranged from 1 to 63 days (mean, 13 days). On the basis of this review, it appears that dogs with late-onset seizures or behavior change, or both, should be suspected of having tumors involving the rostral cerebrum, despite the absence of persistent neurologic deficits commonly associated with cerebral tumors. Further, the onset of abnormalities in the neurologic examination and the time of death seem to occur within predictable time periods.  相似文献   

Hypofractionated radiation therapy of oral melanoma in five cats     

John Farrelly  DVM    David L. Denman  PhD    Ann E. Hohenhaus  DVM    Amiya K. Patnaik  DVM    Philip J. Bergman  DVM  MS  PhD 《Veterinary radiology & ultrasound》2004,45(1):91-93

Five cats with melanoma involving the oral cavity were treated with hypofractionated radiation therapy (RT). Cobalt photons were used to administer three fractions of 8.0 Gray (Gy) for a total dose of 24 Gy. Four cats received radiation on days 0, 7, and 21 and one cat received radiation on days 0, 7, and 13. One of the cats received additional irradiation following the initial treatment course. Two cats received chemotherapy. Their age ranged from 11 to 15 years with a median age of 12 years. Three cats had a response to radiation, including one complete response and two partial responses. All five cats were euthanized due to progression of disease, with one cat having evidence of metastatic disease at the time of euthanasia. The median survival time for the five cats was 146 days (range 66-224 days) from the start of RT. The results of this study suggest that oral melanoma in cats may be responsive to hypofractionated RT, but response does not seem to be durable.  相似文献   

Remote sensing-based assessment of impact of Phailin cyclone on rice in Odisha,India     

Dipanwita Haldar  Rahul Nigam  C. Patnaik  Sujay Dutta  Bimal Bhattacharya 《Paddy and Water Environment》2016,14(4):451-461

Assessing the nature and extent of damage due to natural calamities remains one of the thrust areas in monitoring resource inventory through remote sensing. The effect of the cyclone Phailin and the post-incessant rains during second fortnight of October 2013 on coastal Odisha was studied in terms of rice area flooded, submerged and damaged. Multi-temporal SAR data were analysed to obtain the rice mask, and from this rice mask, the flood affected rice area was determined. Taluka-wise and district-wise crop loss proportion was estimated, and the overall production loss has been estimated. SAR data aided in delineation of flooded regions, while AWiFS NDVI data of subsequent dates showed both continued inundation and crop vigour status post-flood time period. The ground truth indicated that a major portion of the inundated region was not rice but was typha grasses and harvested rice field which should not be accounted as damage to rice crop. The damage on crop yield was difficult to assess; however, the inundation of the crop at panicle initiation and flowering would have impact on grain filling (results in chaffiness) and was considered as completely damaged. Most of the current inundated rice regions fall in this category. It was estimated that a total of 0.167 million hectares and 0.37 million tons of rice crop was lost in the cyclone and floods. The district-level percentage area of rice flooded was communicated to State Remote Sensing Centre in four days timeframe. The overall accuracy obtained for the validation of the ground truth sites was 91.5 %.  相似文献   

Effect of fiber length on mechanical behavior of coir fiber reinforced epoxy composites     

Sandhyarani Biswas  Sanjay Kindo  Amar Patnaik 《Fibers and Polymers》2011,12(1):73-78

Fiber reinforced polymer composites have played a dominant role for a long time in a variety of applications for their high specific strength and modulus. The fiber which serves as a reinforcement in reinforced plastics may be synthetic or natural. To this end, an investigation has been carried out to make use of coir, a natural fiber abundantly available in India. Natural fibers are not only strong and lightweight but also relatively very cheap. The present work describes the development and characterization of a new set of natural fiber based polymer composites consisting of coconut coir as reinforcement and epoxy resin as matrix material. The developed composites are characterized with respect to their mechanical characteristics. Experiments are carried out to study the effect of fiber length on mechanical behavior of these epoxy based polymer composites. Finally, the scanning electron microscope (SEM) of fractured surfaces has been done to study their surface morphology.  相似文献   

Radiation treatment for incompletely resected soft-tissue sarcomas in dogs     

McKnight JA  Mauldin GN  McEntee MC  Meleo KA  Patnaik AK 《Journal of the American Veterinary Medical Association》2000,217(2):205-210

OBJECTIVE: To evaluate efficacy of radiation for treatment of incompletely resected soft-tissue sarcomas in dogs. DESIGN: Prospective serial study. ANIMALS: 48 dogs with soft-tissue sarcomas. PROCEDURE: Tumors were resected to < 3 cm3 prior to radiation. Tumors were treated on alternate days (three 3-Gy fractions/wk) until 21 fractions had been administered. Cobalt 60 radiation was used for all treatments. RESULTS: Five-year survival rate was 76%, and survival rate was not different among tumor types or locations. Four (8%) dogs developed metastases. Eight (17%) dogs had tumor recurrence after radiation. Development of metastases and local recurrence were significantly associated with reduced survival rate. Median survival time in dogs that developed metastases was 250 days. Median disease-free interval for all dogs was 1,082 days. Median time to recurrence was 700 days. Dogs that developed recurrence after a prolonged period responded well to a second surgery. Acute radiation toxicosis was minimal; osteosarcoma developed at the radiation site in 1 dog. CONCLUSIONS AND CLINICAL RELEVANCE: An excellent long-term survival rate may be achieved by treating soft-tissue sarcomas in dogs with resection followed by radiation. Amputation is not necessary for long-term control of soft-tissue sarcomas in limbs. Development of metastases and recurrence of local tumors after radiation treatment are associated with decreased survival rate. Acute and delayed radiation toxicosis was minimal with the protocol used in this study.  相似文献   

Comparison of needle-core (Trucut) biopsy and surgical biopsy for the diagnosis of cutaneous and subcutaneous masses: a prospective study of 51 cases (November 1997-August 1998)     

Aitken ML  Patnaik AK 《Journal of the American Animal Hospital Association》2000,36(2):153-157

Cutaneous or subcutaneous masses in 51 dogs and cats were examined by needle-core (i.e., Trucut) biopsy, and results were compared to results of surgical biopsy to assess the accuracy of the former. Needle-core specimens obtained before surgical biopsy were submitted to a single pathologist who evaluated both samples and was blinded to the results of surgical biopsy when evaluating the Trucut specimen. The results indicate that needle-core biopsy can accurately predict surgical biopsy. Thus, needle-core biopsy performed before surgical excision of masses can facilitate planning and reduce the need for numerous surgical procedures. Needle-core biopsy can direct appropriate treatment of nonmalignant masses.  相似文献   

Prognostic factors in dogs with urinary bladder carcinoma     

Rocha TA  Mauldin GN  Patnaik AK  Bergman PJ 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2000,14(5):486-490

Medical records and biopsy specimens were retrospectively reviewed from 25 dogs diagnosed with unresectable urinary bladder carcinoma and treated with chemotherapy. Our intention was to identify clinical, histologic, and immunohistochemical indicators of prognosis. Immunohistochemical stains for P-glycoprotein, glutathione-S-transferase pi, and factor VIII-related antigen were applied to archived tissue. There were more spayed female dogs than castrated male dogs (76% versus 24%). Transitional cell carcinoma was the most common tumor (88%, n = 22), followed by undifferentiated carcinoma (8%, n = 2) and squamous cell carcinoma (4%, n = 1). Overall median survival was 251 days. Histologic diagnosis and immunohistochemical characteristics did not correlate with prognosis. Spayed females survived significantly longer than castrated males (358 days versus 145 days, P = .042). Dogs that received either doxorubicin or mitoxantrone in addition to a platinum-based chemotherapeutic (either cisplatin or carboplatin) lived significantly longer than those that received only a platinum compound (358 days versus 132 days, P = .042).  相似文献   

Extramedullary plasmacytoma of the gastrointestinal tract in two dogs     

E G MacEwen  A K Patnaik  G F Johnson  A I Hurvitz  R A Erlandson  P H Lieberman 《Journal of the American Veterinary Medical Association》1984,184(11):1396-1398

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Efficacy and Toxicity of Doxorubicin and Cyclophosphamide Used in the Treatment of Selected Malignant Tumors in 23 Cats   总被引：3，自引：1，他引：2  

Guy Neal Mauldin DVM    Robert E. Matus DVM  MS    Amiya K. Patnaik BVSc  MVSc    Betsy R. Bond DVM  Samantha C. Mooney MA 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1988,2(2):60-65

Twenty-three cats with malignant, nonhematopoietic tumors were treated with doxorubicin and cyclophosphamide. Fourteen cats had nonresectable tumors of the mammary gland, and nine had tumors of the oral cavity. Of the cats with mammary gland adenocarcinoma, seven cats had a partial response to treatment and seven cats had no response. Of the cats with oral tumors, one cat had a complete response, three cats had a partial response, and five cats had no response. All 23 cats are dead because of tumor progression or recurrence. Toxic effects were seen in 18 of the cats; most were transient and required no alteration in the treatment protocol. A high response rate combined with acceptable toxicity warrants further evaluation of combination doxorubicin and cyclophosphamide chemotherapy in cats with nonhematopoietic neoplasia.  相似文献   

Spinal meningiomas in dogs: 13 cases (1972-1987)     

J M Fingeroth  R G Prata  A K Patnaik 《Journal of the American Veterinary Medical Association》1987,191(6):720-726

Medical records of 13 dogs with spinal meningiomas were reviewed. Breed predilections were not found. Males outnumbered females 9 to 4, and most of the dogs were middle-aged. All dogs had motor deficits of various degrees, and approximately half of the dogs had clinical signs of mild to moderate spinal pain. The remainder had histories of clinical signs suggestive of chronic discomfort. There was a prolonged (greater than 3 months) delay between the onset of signs and diagnosis, except in 3 dogs. The neurologic courses usually were progressive. Results of noncontrast spinal radiography were normal in 10 dogs; in 3 dogs, the lamina appeared scalloped. Results of myelography contributed to the correct diagnosis in 10 of 12 dogs; however, in 2 dogs, intradural/extramedullary tumors were thought to be intramedullary lesions. A preponderance of cervical meningiomas was found, accounting for 10 of 13 tumors. Lumbar meningiomas were found in the remaining 3 dogs. Surgery was performed in 9 of the dogs, six of which improved after surgery. Poor results were correlated with tumors that involved spinal cord segments of an intumescence, ventrally located tumors, iatrogenic trauma, and tumor invasion into adjacent neural parenchyma. Four of 13 spinal meningiomas were found to be invasive into the spinal cord itself.  相似文献