Selection of reference genes for quantitative PCR analysis in poultry red mite (Dermanyssus gallinae)     

Takuma ARIIZUMI  Shiro MURATA  Sotaro FUJISAWA  Masayoshi ISEZAKI  Naoya MAEKAWA  Tomohiro OKAGAWA  Takumi SATO  Eiji OISHI  Akira TANENO  Satoru KONNAI  Kazuhiko OHASHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(4):558

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Gigantic photoresponse in 1/4-filled-band organic salt (EDO-TTF)2PF6     

Chollet M  Guerin L  Uchida N  Fukaya S  Shimoda H  Ishikawa T  Matsuda K  Hasegawa T  Ota A  Yamochi H  Saito G  Tazaki R  Adachi S  Koshihara SY 《Science (New York, N.Y.)》2005,307(5706):86-89

We report that the organic salt (EDO-TTF)2PF6 with 3/4-filled-band (1/4-filled in terms of holes), which forms an organic metal with strong electron and lattice correlation, shows a highly sensitive response to photoexcitation. An ultrafast, photoinduced phase transition from the insulator phase to the metal phase can be induced with very weak excitation intensity at near room temperature. This response makes the material attractive for applications in switching devices with room-temperature operation. The observed photo-induced spectroscopic change shows that this photoinduced phase transition process is caused by the cooperative melting of charge ordering assisted by coherent phonon generation.  相似文献   

The Selaginella genome identifies genetic changes associated with the evolution of vascular plants     

Banks JA  Nishiyama T  Hasebe M  Bowman JL  Gribskov M  dePamphilis C  Albert VA  Aono N  Aoyama T  Ambrose BA  Ashton NW  Axtell MJ  Barker E  Barker MS  Bennetzen JL  Bonawitz ND  Chapple C  Cheng C  Correa LG  Dacre M  DeBarry J  Dreyer I  Elias M  Engstrom EM  Estelle M  Feng L  Finet C  Floyd SK  Frommer WB  Fujita T  Gramzow L  Gutensohn M  Harholt J  Hattori M  Heyl A  Hirai T  Hiwatashi Y  Ishikawa M  Iwata M  Karol KG  Koehler B  Kolukisaoglu U  Kubo M  Kurata T  Lalonde S  Li K  Li Y  Litt A  Lyons E  Manning G  Maruyama T  Michael TP 《Science (New York, N.Y.)》2011,332(6032):960-963

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Human hypertension caused by mutations in WNK kinases   总被引：1，自引：0，他引：1  

Wilson FH  Disse-Nicodème S  Choate KA  Ishikawa K  Nelson-Williams C  Desitter I  Gunel M  Milford DV  Lipkin GW  Achard JM  Feely MP  Dussol B  Berland Y  Unwin RJ  Mayan H  Simon DB  Farfel Z  Jeunemaitre X  Lifton RP 《Science (New York, N.Y.)》2001,293(5532):1107-1112

Hypertension is a major public health problem of largely unknown cause. Here, we identify two genes causing pseudohypoaldosteronism type II, a Mendelian trait featuring hypertension, increased renal salt reabsorption, and impaired K+ and H+ excretion. Both genes encode members of the WNK family of serine-threonine kinases. Disease-causing mutations in WNK1 are large intronic deletions that increase WNK1 expression. The mutations in WNK4 are missense, which cluster in a short, highly conserved segment of the encoded protein. Both proteins localize to the distal nephron, a kidney segment involved in salt, K+, and pH homeostasis. WNK1 is cytoplasmic, whereas WNK4 localizes to tight junctions. The WNK kinases and their associated signaling pathway(s) may offer new targets for the development of antihypertensive drugs.  相似文献   

Anthocyanins from purple sweet potato Ipomoea batatas cultivar Ayamurasaki suppress the development of atherosclerotic lesions and both enhancements of oxidative stress and soluble vascular cell adhesion molecule-1 in apolipoprotein E-deficient mice     

Miyazaki K  Makino K  Iwadate E  Deguchi Y  Ishikawa F 《Journal of agricultural and food chemistry》2008,56(23):11485-11492

We evaluated the protective potential of anthocyanins from purple sweet potato Ipomoea batatas cultivar Ayamurasaki (APSP) against low-density lipoprotein (LDL) oxidation in vitro and atherosclerotic lesion development in apolipoprotein E-deficient mice given a cholesterol- and fat-enriched diet with or without 1% APSP for 4 weeks. APSP protected LDL against oxidation more potently than other anthocyanins and l-ascorbic acid in vitro. In mice, APSP significantly lowered the atherosclerotic plaque area to about half of the control, the liver level of thiobarbituric acid-reactive substances as an oxidative stress marker, and the plasma level of soluble vascular cell adhesion molecule-1 (sVCAM-1). However, APSP showed no effects on body weight and cholesterol and lipid levels in the plasma. The results suggest that APSP can suppress the development of atherosclerotic lesions and both enhancements of oxidative stress and sVCAM-1 independently of the changes in cholesterol and lipid levels in mice.  相似文献   

Pharmacokinetics of Eugenol in Japanese Flounder,Paralichthys olivaceus          下载免费PDF全文

Akio Tago  Saichiro Yokoyama  Manabu Ishikawa  Shunsuke Koshio 《Journal of the World Aquaculture Society》2018,49(4):780-787

Eugenol, which has been used as an anesthetic for fish, was administered to Japanese flounder, Paralichthys olivaceus (127 ± 50.8 g), by bath treatment at concentrations of 0.025, 0.125, and 0.25 mL/L seawater for 10 min and intramuscular injection at 40 μL/fish to investigate the pharmacokinetic characteristics of eugenol in the plasma of Japanese flounder. In the bath treatment test, plasma eugenol concentration increased with increasing eugenol concentration up to 0.125 mL/L and reached steady state within 5 min. After a 10‐min bath treatment in 0.25 mL/L eugenol, plasma eugenol concentration was about 58.4 µg/mL. After transfer into running seawater, plasma eugenol concentration decreased biphasically with half‐lives of 0.0296 h (α‐phase) and 0.289 h (β‐phase). The AUC_0000→0800 was about 16.5 µg h/mL. In administration by intramuscular injection, plasma eugenol concentration increased rapidly after administration and decreased biphasically with half‐lives of 0.0329 h (α‐phase) and 8.08 h (β‐phase). The AUC_0000→0800 was about 52.5 µg h/mL. In both methods of administration, Japanese flounder with average weight of 127 g were effectively anesthetized when plasma eugenol concentrations were between 2.19 and 4.88 µg/mL.  相似文献   

Effects of Molasses-Urea Supplementation on Weight Gain,Ruminal Fermentation and Major Microbe Populations of Winter-Grazing Sheep in Inner Mongolia     

Li Chang-qing  Alatengdalai  Xue Shu-yuan  Atsushi Asano  Atsushi Tajima  Naoto Ishikawa 《东北农业大学学报(英文版)》2017,24(1)

The present experiment was conducted to determine the effects of Molasses-Urea Supplementation (MUS) on weight gain, ruminal fermentation and major microbial populations in sheep on a winter grazing regime in Inner Mongolia. Total 40 sheep, allowed free consumption of MUS after grazing, served as a treatment group, while 30 sheep, fed only by pasture grazing, served as a control group. Ruminal fermentation parameters, consisted of pH, Bacterial Crude Protein (BCP) and ammonia nitrogen (NH3-N) were measured. In addition, numbers of five symbiotic bacteria were investigated. The results showed as follows: the average daily weight gain, concentration of NH3-N and numbers of protozoa were significantly higher (p<0.05) in the treatment group than those in the control group. Contrastingly, no significant difference was found in BCP concentration and pH between the two groups. At the end of the experiment, the populations of Selenomonas ruminantium,Anaerovibrio lipolytica,Fibrobacter succinogenes,Ruminococcus flaveciens and Ruminococcus albus in the treatment group were significantly higher than those of the control group (p<0.05). These results demonstrated that greater weight gain could be induced during winter in Inner Mongolia by improved nutritional status through promotion of microbial populations using urea and sugar.  相似文献   

Studies on the mechanism of tobacco mosaic virus RNA replication     

Masayuki Ishikawa 《Journal of General Plant Pathology》2017,83(6):410-413

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Depth profiling of photodegraded wood surfaces by confocal Raman microscopy     

Toru Kanbayashi  Yutaka Kataoka  Atsuko Ishikawa  Masahiro Matsunaga  Masahiko Kobayashi  Makoto Kiguchi 《Journal of Wood Science》2018,64(2):169-172

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