Effects of Polyethylene Glycol Administration and Bone Marrow Stromal Cell Transplantation Therapy in Spinal Cord Injury Mice     

Yasutaka ODA  Kenji TANI  Atsunobu ISOZAKI  Tomoya HARAGUCHI  Kazuhito ITAMOTO  Hiroshi NAKAZAWA  Yasuho TAURA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(3):415-421

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Intracellular olfactory response of hippocampal neurons in awake, sitting squirrel monkeys     

T Yokota  A G Reeves  P D MacLean 《Science (New York, N.Y.)》1967,157(792):1072-1074

Intracellular recordings of archicortical neurons in a primate have been made and the responses of these neurons in awake, sitting animals have been observed. Electrical stimulation of the olfactory bulbs elicits excitatory postsynaptic potentials in these neurons, which unlike those evoked by septal stimulation, are subliminal for generating spikes. The olfactory and septal pathways may be considered representative of inputs from exteroceptive and interoceptive systems. The findings are discussed in relation to a paradigm for archicortical conditioning.  相似文献   

Lack of exposed ice inside lunar south pole Shackleton Crater   总被引：2，自引：0，他引：2  

Haruyama J  Ohtake M  Matsunaga T  Morota T  Honda C  Yokota Y  Pieters CM  Hara S  Hioki K  Saiki K  Miyamoto H  Iwasaki A  Abe M  Ogawa Y  Takeda H  Shirao M  Yamaji A  Josset JL 《Science (New York, N.Y.)》2008,322(5903):938-939

The inside of Shackleton Crater at the lunar south pole is permanently shadowed; it has been inferred to hold water-ice deposits. The Terrain Camera (TC), a 10-meter-resolution stereo camera onboard the Selenological and Engineering Explorer (SELENE) spacecraft, succeeded in imaging the inside of the crater, which was faintly lit by sunlight scattered from the upper inner wall near the rim. The estimated temperature of the crater floor, based on the crater shape model derived from the TC data, is less than approximately 90 kelvin, cold enough to hold water-ice. However, at the TC's spatial resolution, the derived albedo indicates that exposed relatively pure water-ice deposits are not on the crater floor. Water-ice may be disseminated and mixed with soil over a small percentage of the area or may not exist at all.  相似文献   

The structure of arthropod hemocyanins   总被引：13，自引：0，他引：13  

B Linzen  N M Soeter  A F Riggs  H J Schneider  W Schartau  M D Moore  E Yokota  P Q Behrens  H Nakashima  T Takagi 《Science (New York, N.Y.)》1985,229(4713):519-524

Hemocyanins are large multi-subunit copper proteins that transport oxygen in many arthropods and molluscs. Comparison of the amino acid sequence data for seven different subunits of arthropod hemocyanins from crustaceans and chelicerates shows many highly conserved residues and extensive regions of near identity. This correspondence can be matched closely with the three domain structure established by x-ray crystallography for spiny lobster hemocyanin. The degree of identity is particularly striking in the second domain of the subunit that contains the six histidines which ligate the two oxygen-binding copper atoms. The polypeptide architecture of spiny lobster hemocyanin appears to be the same in all arthropods. This structure must therefore be at least as old as the estimated time of divergence of crustaceans and chelicerates, about 540 to 600 million years ago.  相似文献   

Malignant Lymphoma with Severe Infiltrative Growth into Skeletal Muscles in WBN/Kob Rats     

Sano T  Ozaki K  Kodama Y  Matsuura T  Narama I 《Journal of toxicologic pathology》2009,22(3):173-178

Although spontaneously occurring neoplasms have been reported repeatedly in F344, SD and Wistar rats, which are commonly used strains for routine toxicologic and carcinogenicity studies, there are only a few reports of malignant lymphoma or lymphatic leukemia except for large granular lymphocytic leukemia (LGL) in F344 rats. Malignant lymphoma (lymphosarcoma) is thought to be uncommon in F344 rats. The authors encountered malignant lymphomas of the non-LGL leukemia type with characteristic pathologic features in WBN/Kob rats. The mean age at onset of the disease in all 13 affected rats (8 males and 5 females) was about 60 weeks. Common and characteristic clinical signs were abnormal gait with hind limb paralysis. Macroscopically, the enlargement of the lymph nodes, spleen and liver was slight to moderate. Scattered multiple white-to-gray nodules encompassed the aorta and assumed a bead-like appearance near the thoracic and lumbar vertebrae. Histopathologically, neoplastic proliferative changes were predominant in the bone marrow tissue of the entire body, and many tumor cells infiltrated the spleen and several lymph nodes. The most striking histological features were constant and severe infiltration of tumor cells in the adipose tissue and skeletal muscle adjacent the thoracic and lumber vertebrae. Immunohistochemically, all tumor cells were positive for B-cell markers (PAX-5, CD79a and CD45) and negative for CD3. From the results of immunohistochemistry and morphological examination, these tumors were diagnosed as malignant B-cell lymphomas.  相似文献   

Stereolithographic biomodeling of equine ovary based on 3D serial digitizing device     

Junpei Kimura  Nobunori Kakusho  Kenji Yamazawa  Yuuko Hirano  Yasuo Nambo  Hideo Yokota  Ryutaro Himeno 《Journal of veterinary science (Suw?n-si, Korea)》2009,10(2):161-163

The 3D internal structure microscopy (3D-ISM) was applied to the equine ovary, which possesses peculiar structural characteristics. Stereolithography was applied to make a life-sized model by means of data obtained from 3D-ISM. Images from serially sliced surfaces contributed to a successful 3D reconstruction of the equine ovary. Photopolymerized resin models of equine ovaries produced by stereolithography can clearly show the internal structure and spatial localizations in the ovary. The understanding of the spatial relationship between the ovulation fossa and follicles and/or corpora lutea in the equine ovary was a great benefit. The peculiar structure of the equine ovary could be thoroughly observed and understood through this model.  相似文献   

Mitochondrial DNA variation and population structure of the Japanese mitten crab Eriocheir japonica   总被引：2，自引：0，他引：2  

Izumi Yamasaki  Goro Yoshizaki  Masashi Yokota  Carlos A. Strüssmann  Seiichi Watanabe 《Fisheries Science》2006,72(2):299-309

ABSTRACT:   The Japanese mitten crab Eriocheir japonica is a common grapsid species found throughout freshwater and estuarine regions in Japan. In order to obtain information on the genetic variation and population structure of this species, a polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) analysis was conducted on the cytochrome oxidase subunit I (COI) of mitochondrial DNA, on 666 individuals from 19 sample sites covering the three main geographic regions of Japan (Main Islands, Okinawa, and Ogasawara). Genetic analysis using seven restriction enzymes produced an array of 61 composite haplotypes. Three regional groups corresponding to the three geographic regions were clearly identified by cluster and molecular variance model ( amova ) analyses. Each of the three groups showed dominant haplotypes that were almost completely absent in populations from the other geographic areas. Comparison with published information for other species indicates that the degree of genetic divergence between these three main groups is equivalent to the genetic distance between congeneric species. Thus, the population structure of the Japanese mitten crab, as inferred from mtDNA analysis, is formed by genetically distinct groups that closely reflect their geographic distribution in the Japanese archipelago as well as restricted gene flow.  相似文献