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Makoto NAKATA Yasutsugu MIWA Masaya TSUBOI Kazuyuki UCHIDA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2014,76(12):1659-1662
An 8-year-old spayed female
Netherland Dwarf rabbit presented with a two-month history of dyspnea and snoring. A
computed tomography (CT) scan of the head revealed mass lesions in the right nasal cavity.
Surgical exenteration of the lesions was performed, and the histopathological diagnosis
was an intranasal adenocarcinoma. On the basis of this diagnosis, radiotherapy was planned
and consisted of eight fractions of 6 Gy administered once a week. After the completion of
radiation therapy, the soft tissue density in the right nasal cavity, as detected by CT,
significantly decreased. The prognosis has remained good for over 3 years after treatment.
This paper is the first to describe the clinical and pathological features of an
intranasal tumor in a rabbit. 相似文献
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Yui HIROSE Mona UCHIDA Masaya TSUBOI Takayuki NAKAGAWA Leo YAGA Shingo MAEDA Yasuyuki MOMOI Yugo KURIKI Mako KAMIYA Yasuteru URANO Tomohiro YONEZAWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2022,84(4):593
Since gamma-glutamyl transpeptidase (GGT) is highly and locally expressed in human breast cancer, a GGT-enzymatically activatable fluorescent probe, gamma-glutamyl hydroxymethyl rhodamine green (gGlu-HMRG), has been developed to detect the human breast cancer area with high performance. In this study, GGT expression and the efficacy of gGlu-HMRG on visualization were investigated in canine mammary gland tumors (MGT). Seventeen non-fixed fresh-frozen MGT specimens and each peritumoral control tissue were utilized. The GGT mRNA levels were highly observed in the tumor specimens compared with the control. GGT immunostaining was mostly observed on the cell membrane and cytosol of the alveolar and duct mammary epithelium of MGT tissues. These signals were strongly positive in several cases while they were mild to not observed in other cases. When gGlu-HMRG solution was dropped to the non-fixed tissue pieces of MGT or control tissues, the fluorescence intensities (FIs) were measured using Maestro in-vivo imaging device. FIs in MGT tissues were significantly higher than each control tissue 20 min after treatment. Based on Youden index method said that the maximum sensitivity and specificity of FI was 82.4% and 82.4%. These findings suggest that GGT is highly expressed in several MGTs in dogs and gGlu-HMRG could visualize at least a part of MGT tissues in dogs. Nevertheless, it should be needed to assess the false-negative areas more carefully in canine than human cases. 相似文献