Lupus-Type "Anticoagulant" in a Dog With Hemolysis and Thrombosis   总被引：1，自引：1，他引：0  

Michael S. Stone  Ian B. Johnstone  Marjory Brooks  Trent K. Bollinger  Susan M. Cotter 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(1):57-61

A circulating anticoagulant was detected in a 2-year-old Chesapeake Bay Retriever with hemolytic anemia, nephrotic syndrome, thrombocytopenia, polyarthropathy, and pulmonary thromboembolism. A persistent prolongation of the activated partial thromboplastin time (aPTT) was detected, and it did not correct with repeated administration of fresh frozen plasma. The aPTT was still prolonged, with a 1:1 mixture of patient's plasma and normal dog plasma in vitro, suggesting the presence of a circulating inhibitor. Results of assays to characterize the inhibitor were compatible with those described for the lupus anticoagulant in human patients with systemic lupus erythematosus. Paradoxically, patients having the lupus anticoagulant are at increased risk for thrombosis. Pulmonary thromboembolism has been described as a frequent complication of immune-mediated hemolytic anemia in the dog, and the presence of a circulating anticoagulant should be considered as a potential mechanism.  相似文献   

USE OF MONOCLONAL ANTIBODY GB 24 and PROPIDIUM IODIDE FOR SIMULTANEOUS ASSESSMENT OF ACROSOMAL STATUS and VITALITY IN BOAR SPERMATOZOA     

P. Renard  B. Drénou  J.F. Griveau  D. Le Lannou 《Reproduction in domestic animals》1995,31(1):255-256

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Temporary Bile Diversion in Cats with Experimental Extrahepatic Bile Duct Obstruction     

DARIEN LAWRENCE BSc  BVSC    JAMIE R. BELLAH DVM  Dipiomate ACVS    D. J. MEYER DVM  Dipiomate ACVIM  Dipiomate ACVP  L. ROTH DVM  PhD  Dipiomate ACVP 《Veterinary surgery : VS》1992,21(6):446-451

The use of a cholecystostomy catheter for temporary bile diversion was investigated in four cats with experimentally induced extrahepatic bile duct obstruction. Eighteen days after ligation of the common bile duct, a 6.5 F accordion catheter was placed in the gallbladder with a 22 g Hawkins needle-guide system through a paracostal incision. Biochemical parameters and fasting serum bile acids were monitored for 16 days. There were significant decreases in mean total bilirubin, aspartate aminotransferase, and fasting serum bile acids within 72 hours of bile diversion, and in mean alanine aminotransferase within 96 hours. Attitude and appetite improved, and the catheter was tolerated well. Positive bile cultures developed in three cats. Histologic changes in the gallbladder included mucosal ulcerations, a mixed inflammatory cellular infiltration, and fibrosis of the submucosa.  相似文献   

Effect of inoculum density of Macrophomina phaseolina on seedling susceptibility of six conifer species     

A. H. McCain  R. F. Scharpf 《Forest Pathology》1989,19(2):119-123

The severity of charcoal root disease of conifer seedlings (Abies concolor, A. magnified, Pinus jeffreyi, P. lambertiana, and Pseudotsuga menziesii) was a power function of the sclerotial density of the fungus (Macrophomina phaseolina) in nursery soil.  相似文献   

Quantitative Aspects of Thyroid Scintigraphy With Pertechnetate (^99mTcO₄) in Cats     

Ariana M.P. Nap  Yvonne W.E.A. Pollak  Walter E. van den  Brom Ad Rijnberk DVM  PhD 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1994,8(4):302-303

Thyroidal ^99mTcO₄(pertechnetate) uptake percentages were determined in unanesthetized euthyroid (n = 13) and hyperthyroid (n = 18) cats. Maximal uptakes were observed 60 minutes after IV injection of the radionuclide and ranged from 0.3 to 3.9% of the dose in euthyroid cats (median 2.23%) and from 5.2% to 23.9% of the dose in hyperthyroid cats (median 14.8%) ( P < .05). There were no overlaps in pertechnetate uptake percentages during any of the intervals evaluated. It is concluded that the optimal time for visualization of the thyroid by ^99mTcO₄-scanning is 60 minutes after IV injection of the radionuclide. Calculation of the percentage uptake is of additional diagnostic value.  相似文献   

Coccidioidomycosis in 48 Cats: A Retrospective Study (1984–1993)     

Russell T. Greene  Gregory C. Troy 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1995,9(2):86-91

Coccidioidomycosis was diagnosed in 48 cats. Forty-one cases were identified within a period of 3 years. Coccidioides immitis was revealed by cytological or histopathological examinations, or culture in 70% of cats. The remaining 30% of cases were diagnosed by appropriate clinical signs, radiographic lesions, and serological test results. The average age of affected cats was 6.2 years with a median age of 5.0 years. Fifty-four percent (n = 26) were female and 46% (n = 22) were male. Domestic shorthaired and longhaired breeds comprised 89% (n = 41) of affected cats. Sixty-seven percent of cases were diagnosed during the 6-month period of December through May. Cats infected with C immitis were presented for evaluation of dermatologic (56%), respiratory (25%), musculoskeletal (19%), and neurological or ophthalmologic signs (19%). Fever, inappetence, and weight loss were present in 44% of the cats. Duration of clinical signs before diagnosis was less than 4 weeks in 85% (n = 42) of cats, with an average of 3.8 weeks and a median of 2 weeks. Agar gel immunodiffusion tests were positive in all 39 cats tested at sometime during the course of their disease. Hyperproteinemia (greater than 7.9 g/dL) was present in 52% (10/23) of cases. The majority of cats (n = 39) were negative for feline leukemia virus. Antibodies to feline immunodeficiency virus were absent in the 19 cats tested. Ketoconazole was the most common antifungal agent used to treat cats with Coccidioidomycosis. Duration of treatment ranged from less than 1 week to 43 months. Thirty-two cats are currently asymptomatic, with or without treatment. Eleven cats died or were euthanized. Five cats were lost to follow-up. Ketoconazole likely is more suppressive than curative because relapses were common after discontinuing therapy.  相似文献   

FREEZING BOAR SEMEN IN FLAT PLASTIC BAGS MEMBRANE INTEGRITY and FERTILITY     

H. Rodriguez-Martinez  B. Eriksson  N. Lundeheim 《Reproduction in domestic animals》1995,31(1):161-168

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Biovailability of ivermectin administered orally to dogs     

C. P. Daurio  E. N. Cheung  A. R. Jeffcoat  B. J. Skelly 《Veterinary research communications》1992,16(2):125-130

The bioavailability of three formulations of ivermectin was determined following oral administration to dogs. The average peak plasma level (C _max) of ivermectin administered in the standard tablet formulation at 6 and 100 µg/kg of body weight was 2.97 and 44.31 ng/g, respectively. This suggest dose-dependent pharmacokinetics.C _max and total ivermectin bioavailability, as assessed from the area under the plasma curve (AUC), were similar between two tablet formulations of ivermectin administered at 100 µg/kg. Furthermore,C _max was similar following administration of radiolabelled ivermectin at 6 µg/kg in either a beef-based chewable formulation or in the standard tablet formulation.  相似文献   

Presidential address conferring Honorary Membership of EAVPT on Prof. Dr Adelbert van Miert     

M. Debackere 《Journal of veterinary pharmacology and therapeutics》1995,18(1):78-78

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Endocrine changes of reproductive functions in aging male animals     

E. Schallenberger  A. Brückmann 《Reproduction in domestic animals》1995,30(4):251-255

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