Effect of ingesta on systemic availability of chloramphenicol from two oral preparations in cats   总被引：1，自引：0，他引：1  

A. D. J. WATSON 《Journal of veterinary pharmacology and therapeutics》1979,2(2):117-121

On five separate occasions, five adult cats were dosed orally with 100 mg chloramphenicol tablets or chloramphenicol palmitate suspension. Each preparation was given once when the cats were fasted and once when fed ad lib. In addition, fasted cats were given the tablet preparation on one occasion with 10 ml water orally immediately afterwards. Chloramphenicol concentrations were determined at intervals after dosing, and all urine passed in 24 h after dosing was collected for chloramphenicol assay. The initial plasma antibiotic concentrations were lower with chloramphenicol palmitate suspension than with chloramphenicol tablets, and the bioavailability of chloramphenicol from the palmitate ester was especially poor in starved cats. Chloramphenicol palmitate may thus be undesirable for antimicrobial therapy in inappetent cats. Food and fluid did not appear to influence the availability of chloramphenicol from the tablet preparation, although effects on plasma drug concentrations within 1.5 h of dosing would have been missed in this study. A relatively large proportion of an oral dose of chloramphenicol is excreted unchanged in feline urine. Because of the potential toxicity of the drug, chloramphenicol dose rates should be restricted in cats with renal insufficiency or another antibiotic used.  相似文献   

ON THE DETECTION AND DIFFERENTIATION OF MICROFILARIAE AND THE DIAGNOSIS OF CANINE HEARTWORM DISEASE     

A. D. J. WATSON B.V.Sc. 《Australian veterinary journal》1973,49(7):363-363

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Reingestion in the hare Lepus europaeus Pal     

WATSON JS  TAYLOR RH 《Science (New York, N.Y.)》1955,121(3139):314

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Zinc-65 in marine organisms along the Oregon and Washington coasts     

WATSON DG  DAVIS JJ  HANSON WC 《Science (New York, N.Y.)》1961,133(3467):1826-1828

The concentration of zinc-65 in marine animals and plants near the mouth of the Columbia River is presented. Amounts of radiozinc found in the biota diminished rapidly with the distance from the river mouth. The highest levels were found in plankton, algae, and mollusks. Of the human foods, oysters exhibited the highest levels.  相似文献   

STUDIES OF SOIL ORGANO-MINERAL FRACTIONS     

J. R. WATSON  J. W. PARSONS 《European Journal of Soil Science》1974,25(1):9-15

Sand-, silt-, and clay-size organo-mineral fractions were isolated in bulk from surface horizons of five soils following ultrasonic dispersion in water. Good clay separation was achieved for all except one highly organic, calcareous clay soil. Organic-N and -C were concentrated in the clay and silt fractions but for each soil the organic C : N ratio decreased in the order sand > silt > whole soil > clay. Acid hydrolysis of the silt and clay fractions revealed a slight concentration of amino acid-N and NH₄-N in the clays but only small differences in the distribution of individual amino acids were observed. The results suggest that both silt and clay fractions may be important in the stabilization of soil organic matter.  相似文献   

Quantitative differentiation of minute amounts of the coproporphyrin isomers (I and III) based on fluorescence behavior     

SCHWARTZ S  HAWKINSON VE  WATSON CJ 《Science (New York, N.Y.)》1946,103(2672):338-340

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Systemic antibacterial drug use in dogs in Australia     

ADJ WATSON  JE MADDISON 《Australian veterinary journal》2001,79(11):740-746

A survey of veterinarians' use of antibacterial drugs was conducted by distributing a questionnaire to Australian practitioners. Respondents were asked to indicate their general patterns of use of various systemic antibacterial drugs and drug combinations in dogs and their approach to certain specified clinical disorders. Overall, antibacterials of the p-lactam type (penicillins and cephalosporins) were most commonly used. Other antibacterials with substantial use were doxycycline, sulphonamide-trimethoprim, metronidazole, fluoroquinolones and clindamycin. Drug selection for different disorders was generally appropriate when compared with recommendations in recent texts, although inappropriate use was evident in some circumstances.  相似文献   

Blood lead, urinary delta aminolevulinic acid and the diagnosis of lead poisoning in dogs     

P. J. CANFIELD  A. J. FAIRBURN  A. D. J. WATSON 《Australian veterinary journal》1984,61(10):323-324

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Canine histiocytic ulcerative colitis   总被引：1，自引：0，他引：1  

RK CHURCHER  ADJ WATSON 《Australian veterinary journal》1997,75(10):710-713

Objective To assess prevalence, breed predilection, response to therapy and prognosis of canine histiocytic ulcerative colitis (CHUC).
Design A retrospective study of cases of CHUC seen at Sydney University Veterinary Teaching Hospital (SUVTH) over a 20-year period (1975 -1994).
Procedure Case records of all dogs in which colitis was suspected were reviewed. Dogs were diagnosed with CHUC based on colonorectal biopsy and histopathological examination.
Results CHUC was diagnosed in 8 of 57 dogs presented for colitis. All affected dogs were Boxers and six were female. Dogs with milder clinical signs showed moderately good response to therapy. Four dogs were still alive 1 to 7 years after diagnosis. Three dogs were euthanased, one for reasons other than CHUC, and one was lost to follow-up.
Conclusions Young boxer dogs with relatively mild signs of CHUC may respond moderately well to medical and dietary therapy with fair prognosis. Euthanasia early in the course of the disease may be unwarranted. Prevalence may be increasing within the SUVTH referral population.  相似文献   

Idiopathic neurogenic diabetes insipidus in a cat   总被引：1，自引：0，他引：1  

M. H. COURT  A. D. J. WATSON 《Australian veterinary journal》1983,60(8):245-247

SUMMARY A 5-year-old, domestic long-haired cat was presented for examination because of polydipsia, polyuria and inappropriate urination of 3 months' duration. Neurogenic diabetes insipidus was diagnosed, based on hyposthenuria with failure to concentrate urine in response to water deprivation and positive response to antidiuretic hormone administration. Treatment with hydrochlorothiazide or chlorpropamide orally gave inadequate antidiuresis, but response to injections of vasopressin tannate in oil was sufficient for satisfactory management.  相似文献