In this issue – October 2010     

AE Jackson 《Australian veterinary journal》2010,88(10):371-373

Computed tomography diagnosis of brain infarction in dogs · Tibial tuberosity advancement in canine stifles · Holter monitoring in dogs with mitral valve disease · Staggers in horses grazing paspalum infected with Claviceps paspali · Distal luxation of the patella in a horse · Escherichia coli and Salmonella serotypes in sheep at slaughter · Alzheimer type II astrocytes in the brains of pigs with salt poisoning · Classification of infectious bronchitis viruses in poultry field specimens · Mortality events in sea-caged yellowtail kingfish  相似文献   

Paleoanthropology. Lucy's tour abroad sparks protests     

Gibbons A 《Science (New York, N.Y.)》2006,314(5799):574-575

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Paleoanthropology. A rare meeting of the minds     

Gibbons A 《Science (New York, N.Y.)》2006,312(5781):1739-1740

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A regulatory SNP causes a human genetic disease by creating a new transcriptional promoter     

De Gobbi M  Viprakasit V  Hughes JR  Fisher C  Buckle VJ  Ayyub H  Gibbons RJ  Vernimmen D  Yoshinaga Y  de Jong P  Cheng JF  Rubin EM  Wood WG  Bowden D  Higgs DR 《Science (New York, N.Y.)》2006,312(5777):1215-1217

We describe a pathogenetic mechanism underlying a variant form of the inherited blood disorder alpha thalassemia. Association studies of affected individuals from Melanesia localized the disease trait to the telomeric region of human chromosome 16, which includes the alpha-globin gene cluster, but no molecular defects were detected by conventional approaches. After resequencing and using a combination of chromatin immunoprecipitation and expression analysis on a tiled oligonucleotide array, we identified a gain-of-function regulatory single-nucleotide polymorphism (rSNP) in a nongenic region between the alpha-globin genes and their upstream regulatory elements. The rSNP creates a new promoterlike element that interferes with normal activation of all downstream alpha-like globin genes. Thus, our work illustrates a strategy for distinguishing between neutral and functionally important rSNPs, and it also identifies a pathogenetic mechanism that could potentially underlie other genetic diseases.  相似文献   

Bovine epigastric heteropagus in Trinidad and Tobago: a case study     

Seebaransingh RA  Adogwa AO  Gibbons IR 《The Veterinary record》2006,159(2):49-50

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American Association of Physical Anthropologists. Older dads have healthier kids than you think     

Gibbons A 《Science (New York, N.Y.)》2012,336(6081):539

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American Association of Physical Anthropologists. For early hominins in Africa, many ways to take a walk     

Gibbons A 《Science (New York, N.Y.)》2012,336(6081):538

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Ancient DNA. A crystal-clear view of an extinct girl's genome     

A Gibbons 《Science (New York, N.Y.)》2012,337(6098):1028-1029

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Clovis age Western Stemmed projectile points and human coprolites at the Paisley Caves     

DL Jenkins  LG Davis  TW Stafford  PF Campos  B Hockett  GT Jones  LS Cummings  C Yost  TJ Connolly  RM Yohe  SC Gibbons  M Raghavan  M Rasmussen  JL Paijmans  M Hofreiter  BM Kemp  JL Barta  C Monroe  MT Gilbert  E Willerslev 《Science (New York, N.Y.)》2012,337(6091):223-228

The Paisley Caves in Oregon record the oldest directly dated human remains (DNA) in the Western Hemisphere. More than 100 high-precision radiocarbon dates show that deposits containing artifacts and coprolites ranging in age from 12,450 to 2295 (14)C years ago are well stratified. Western Stemmed projectile points were recovered in deposits dated to 11,070 to 11,340 (14)C years ago, a time contemporaneous with or preceding the Clovis technology. There is no evidence of diagnostic Clovis technology at the site. These two distinct technologies were parallel developments, not the product of a unilinear technological evolution. "Blind testing" analysis of coprolites by an independent laboratory confirms the presence of human DNA in specimens of pre-Clovis age. The colonization of the Americas involved multiple technologically divergent, and possibly genetically divergent, founding groups.  相似文献   

Ultrasonographic findings of feline cholangitis     

Marolf AJ  Leach L  Gibbons DS  Bachand A  Twedt D 《Journal of the American Animal Hospital Association》2012,48(1):36-42

Cholangitis is a common inflammatory disorder of the biliary system in cats. There are two major forms based on the predominate type of inflammatory cell infiltrates: lymphocytic or neutrophilic. Ultrasound is a common imaging modality used in these patients. This retrospective study evaluated the ultrasound examinations of 26 cats with a histologic diagnosis of cholangitis. Most cats with cholangitis had sonographically normal liver size, echogenicity, and normal biliary systems. Statistically significant sonographic changes for cats with cholangitis included hyperechoic liver parenchyma, hyperechoic gallbladder contents, and increased pancreatic size. No statistically significant changes were noted to distinguish lymphocytic and neutrophilic forms of cholangitis. Cats with the sonographic features of diffuse liver hyperechogenicity, gallbladder contents and enlarged pancreas may suggest cholangitis.  相似文献