Development of a Strain of Houseflies Resistant to DDT     

Lindquist AW  Wilson HG 《Science (New York, N.Y.)》1948,107(2776):276-277

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Review of the National Oceanic and Atmospheric Administration (NOAA) website ( http://www.noaa.gov/ )     

Rosanna T. Lindquist 《Journal Of Agricultural & Food Information》2014,15(2):149-150

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Review of Brewing, 2nd ed., by M. J. Lewis and T. W. Young.     

Rosanna Lindquist 《Journal Of Agricultural & Food Information》2014,15(3)

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Nucleated conformational conversion and the replication of conformational information by a prion determinant   总被引：2，自引：0，他引：2  

Serio TR  Cashikar AG  Kowal AS  Sawicki GJ  Moslehi JJ  Serpell L  Arnsdorf MF  Lindquist SL 《Science (New York, N.Y.)》2000,289(5483):1317-1321

Prion proteins can serve as genetic elements by adopting distinct physical and functional states that are self-perpetuating and heritable. The critical region of one prion protein, Sup35, is initially unstructured in solution and then forms self-seeded amyloid fibers. We examined in vitro the mechanism by which this state is attained and replicated. Structurally fluid oligomeric complexes appear to be crucial intermediates in de novo amyloid nucleus formation. Rapid assembly ensues when these complexes conformationally convert upon association with nuclei. This model for replicating protein-based genetic information, nucleated conformational conversion, may be applicable to other protein assembly processes.  相似文献   

Eradication of Screw-Worms through Release of Sterilized Males     

Bushland RC  Lindquist AW  Knipling EF 《Science (New York, N.Y.)》1955,122(3163):287-288

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Differential Rotation and Dynamics of the Solar Interior     

MJ Thompson  J Toomre  ER Anderson  HM Antia  G Berthomieu  D Burtonclay  SM Chitre  J Christensen-Dalsgaard  T Corbard  M DeRosa  CR Genovese  DO Gough  DA Haber  JW Harvey  F Hill  R Howe  SG Korzennik  AG Kosovichev  JW Leibacher  FP Pijpers  J Provost  EJ Rhodes  J Schou  T Sekii  PB Stark  PR Wilson 《Science (New York, N.Y.)》1996,272(5266):1300-1305

Splitting of the sun's global oscillation frequencies by large-scale flows can be used to investigate how rotation varies with radius and latitude within the solar interior. The nearly uninterrupted observations by the Global Oscillation Network Group (GONG) yield oscillation power spectra with high duty cycles and high signal-to-noise ratios. Frequency splittings derived from GONG observations confirm that the variation of rotation rate with latitude seen at the surface carries through much of the convection zone, at the base of which is an adjustment layer leading to latitudinally independent rotation at greater depths. A distinctive shear layer just below the surface is discernible at low to mid-latitudes.  相似文献   

Chemical Usurpation of a Nest by Paper Wasp Parasites     

AG Bagneres  MC Lorenzi  G Dusticier  S Turillazzi  JL Clement 《Science (New York, N.Y.)》1996,272(5263):889-892

The paper wasp Polistes atrimandibularis is an obligatory social parasite of another Polistes species, P. biglumis bimaculatus. To control the host nest, the parasite sequentially changes the composition of its chemical signature, the cuticular hydrocarbons, during the colonial cycle. Gas chromatography-mass spectrometry of the cuticular hydrocarbons at every stage of the cycle showed that the parasite can switch on and off an entire chemical family, namely, the unsaturated hydrocarbons. In this way the parasite can match the host signature at a critical moment of the colonial cycle.  相似文献   

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol     

Ma J  Lindquist S 《Science (New York, N.Y.)》2002,298(5599):1785-1788

A rare conformation of the prion protein, PrPSc, is found only in mammals with transmissible prion diseases and represents either the infectious agent itself or a major component of it. The mechanism for initiating PrPSc formation is unknown. We report that PrP retrogradely transported out of the endoplasmic reticulum produced both amorphous aggregates and a PrPSc-like conformation in the cytosol. The distribution between these forms correlated with the rate of appearance in the cytosol. Once conversion to the PrPSc-like conformation occurred, it was sustained. Thus, PrP has an inherent capacity to promote its own conformational conversion in mammalian cells. These observations might explain the origin of PrPSc.  相似文献   

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers     

Shorter J  Lindquist S 《Science (New York, N.Y.)》2004,304(5678):1793-1797

The protein-remodeling factor Hsp104 governs inheritance of [PSI+], a yeast prion formed by self-perpetuating amyloid conformers of the translation termination factor Sup35. Perplexingly, either excess or insufficient Hsp104 eliminates [PSI+]. In vitro, at low concentrations, Hsp104 catalyzed the formation of oligomeric intermediates that proved critical for the nucleation of Sup 35 fibrillization de novo and displayed a conformation common among amyloidogenic polypeptides. At higher Hsp104 concentrations, amyloidogenic oligomerization and contingent fibrillization were abolished. Hsp104 also disassembled mature fibers in a manner that initially exposed new surfaces for conformational replication but eventually exterminated prion conformers. These Hsp104 activities differed in their reaction mechanism and can explain [PSI+] inheritance patterns.  相似文献   

Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization     

Putnam NH  Srivastava M  Hellsten U  Dirks B  Chapman J  Salamov A  Terry A  Shapiro H  Lindquist E  Kapitonov VV  Jurka J  Genikhovich G  Grigoriev IV  Lucas SM  Steele RE  Finnerty JR  Technau U  Martindale MQ  Rokhsar DS 《Science (New York, N.Y.)》2007,317(5834):86-94

Sea anemones are seemingly primitive animals that, along with corals, jellyfish, and hydras, constitute the oldest eumetazoan phylum, the Cnidaria. Here, we report a comparative analysis of the draft genome of an emerging cnidarian model, the starlet sea anemone Nematostella vectensis. The sea anemone genome is complex, with a gene repertoire, exon-intron structure, and large-scale gene linkage more similar to vertebrates than to flies or nematodes, implying that the genome of the eumetazoan ancestor was similarly complex. Nearly one-fifth of the inferred genes of the ancestor are eumetazoan novelties, which are enriched for animal functions like cell signaling, adhesion, and synaptic transmission. Analysis of diverse pathways suggests that these gene "inventions" along the lineage leading to animals were likely already well integrated with preexisting eukaryotic genes in the eumetazoan progenitor.  相似文献