Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007.   总被引：25，自引：0，他引：25  

Cathy A Brown  Kyu-Shik Jeong  Robert H Poppenga  Birgit Puschner  Doris M Miller  Angela E Ellis  Kyung-Il Kang  Steffen Sum  Alexis M Cistola  Scott A Brown 《Journal of veterinary diagnostic investigation》2007,19(5):525-531

Sixteen animals affected in 2 outbreaks of pet food-associated renal failure (2 dogs in 2004; 10 cats and 4 dogs in 2007) were evaluated for histopathologic, toxicologic, and clinicopathologic changes. All 16 animals had clinical and laboratory evidence of uremia, including anorexia, vomiting, lethargy, polyuria, azotemia, and hyperphosphatemia. Where measured, serum hepatic enzyme concentrations were normal in animals from both outbreaks. All animals died or were euthanized because of severe uremia. Distal tubular lesions were present in all 16 animals, and unique polarizable crystals with striations were present in distal tubules or collecting ducts in all animals. The proximal tubules were largely unaffected. Crystals and histologic appearance were identical in both outbreaks. A chronic pattern of histologic change, characterized by interstitial fibrosis and inflammation, was observed in some affected animals. Melamine and cyanuric acid were present in renal tissue from both outbreaks. These results indicate that the pet food-associated renal failure outbreaks in 2004 and 2007 share identical clinical, histologic, and toxicologic findings, providing compelling evidence that they share the same causation.  相似文献   

Sarcoids in two captive tapirs (Tapirus bairdii): clinical, pathological and molecular study     

Kidney BA  Berrocal A 《Veterinary dermatology》2008,19(6):380-384

This case report describes for the first time sarcoids in tapirs (Tapirus bairdii), namely, a 2-year-old male and a 3.6-year-old female born and housed at the same facility. The male presented with a 3-cm nodular, red, pedunculated, hairless, ulcerated mass on the inner surface of the left pinna. No recurrence or additional growths were present during the 3 years following surgical excision of the mass. The female presented with a similar 2-cm mass on the inner surface of the right pinna, which recurred 2 months following surgical excision, but was subsequently successfully treated locally with liquid nitrogen with no further recurrence during a 2-year follow-up period. Histologically, these two masses closely resembled equine sarcoids. Similarly, an association with bovine papillomavirus 1 was demonstrated using polymerase chain reaction and in situ hybridization.  相似文献   

Shifting application dates on cereal reduces pesticide transfer via subsurface drainage based on water flow forecasts during autumn applications     

Tournebize Julien  Alexis Jeantet  Jonathan Marks-Perreau  Alain Dutertre  Julie Maillet-Mezeray 《Pest management science》2023,79(9):3058-3070

  相似文献   

Nasal rhinosporidiosis in a mule          下载免费PDF全文

Berrocal A  López A 《The Canadian veterinary journal. La revue veterinaire canadienne》2007,48(3):305-306

A mass was removed from the nostril of a mule that exhibited unilateral epistaxis and nasal discharge. Impression smears revealed oval structures consistent with spores of Rhinosporidium seeberi. Microscopically, the mass was composed of fibrovascular granulomatous tissue containing sporangia R. seeberi. Surgical excision and antifungal treatment proved curative.  相似文献   

New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispa     

Irina Gladkikh  Margarita Monastyrnaya  Elena Zelepuga  Oksana Sintsova  Valentin Tabakmakher  Oksana Gnedenko  Alexis Ivanov  Kuo-Feng Hua  Emma Kozlovskaya 《Marine drugs》2015,13(10):6038-6063

Sea anemones are a rich source of Kunitz-type polypeptides that possess not only protease inhibitor activity, but also Kv channels toxicity, analgesic, antihistamine, and anti-inflammatory activities. Two Kunitz-type inhibitors belonging to a new Heteractis crispa RG (HCRG) polypeptide subfamily have been isolated from the sea anemone Heteractis crispa. The amino acid sequences of HCRG1 and HCRG2 identified using the Edman degradation method share up to 95% of their identity with the representatives of the HCGS polypeptide multigene subfamily derived from H. crispa cDNA. Polypeptides are characterized by positively charged Arg at the N-terminus as well as P1 Lys residue at their canonical binding loop, identical to those of bovine pancreatic trypsin inhibitor (BPTI). These polypeptides are shown by our current evidence to be more potent inhibitors of trypsin than the known representatives of the HCGS subfamily with P1Thr. The kinetic and thermodynamic characteristics of the intermolecular interactions between inhibitors and serine proteases were determined by the surface plasmon resonance (SPR) method. Residues functionally important for polypeptide binding to trypsin were revealed using molecular modeling methods. Furthermore, HCRG1 and HCRG2 possess anti-inflammatory activity, reducing tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) secretions, as well as proIL-1β expression in lipopolysaccharide (LPS)-activated macrophages. However, there was no effect on nitric oxide (NO) generation.  相似文献   

In vitro effects of Tabernaemontana citrifolia extracts on Haemonchus contortus     

C. Marie-Magdeleine  M. Mahieu  S. D’Alexis  L. Philibert  H. Archimede 《Research in veterinary science》2010,89(1):88-92

Tabernaemontana citrifolia (Apocynaceae) is traditionally used as an anthelmintic preparation for ruminants in Guadeloupe (French West Indies). This study was carried out to evaluate the in vitro effect of this plant against the parasitic nematode of small ruminants Haemonchus contortus. Three extracts (aqueous, methanolic and dichloromethane) of T. citrifolia fruit, leaf and root were tested on four developmental stages of the parasite, using egg hatch assay (EHA), larval development assay (LDA), L3 migration inhibition assay (LMI), and adult worm motility assay (AWM). Compared to the negative control, significant effects were observed for the different parts of T. citrifolia but with differences depending on the parasitic stage; efficacies on the larval development of H. contortus from 88.9% to 99.8% for fruit, from 72.1% to 83.8% for root and from 33.5% to 85% for leaf with dose-dependent effect for the methanolic extract. The root gave the best result on EHA (22.7% efficacy for dichloromethane extract) and AWM (56% efficacy, with dose-dependent effect for dichloromethane extract) and the leaf on LMI (49.4% efficacy). These results suggest that T. citrifolia possess anthelmintic activity against H. contortus. The active ingredients responsible for the activity could be the alkaloid compounds present in the plant parts of the plant.  相似文献   

Stop me if you can: quantification of the effect of interfaces between plots on the dispersal of Cosmopolites sordidus     

Alexis Delaplace  Mathieu Coulis  Laure Chapillon  Gwenaëlle Cottin  Philippe Tixier 《Pest management science》2023,79(12):5106-5115

BACKGROUND

Cosmopolites sordidus is one of the most damaging pests of banana worldwide. To date, most studies have addressed the control of this pest at the plot level, without considering the landscape scale, whereas between plots dispersion could be important. The aim of this study was to investigate the ability of C. sordidus to cross contrasted field interfaces. The 10 following interfaces were investigated: forests, hedgerows, field tracks, grassy areas, finely and coarsely tilled soil zones, ditches with and without water, vegetable gardening zones, and pheromone trap lines. Individually marked weevils were released on one side of the interface and recovered daily on the other side, allowing the estimation of the velocity and the crossing success of C. sordidus for each interface.

RESULTS

Highest permeabilities (with a crossing success above 70%) were obtained for vegetable gardening zones, finely tilled soil zones, forests, and coarsely tilled soil zones. Intermediate permeabilities were measured for hedgerows, field tracks, grassy areas, and ditches without water. Only the line of pheromone traps and submerged ditches had a strong barrier effect on C. sordidus, with a crossing success below 12%. Wind strength, percentage of sky, and vegetation height were negatively correlated to the C. sordidus crossing success.

CONCLUSION

Overall, our results showed that only ditches with water and lines of pheromone traps were efficient in stopping the dispersal of C. sordidus. The next step will be to conduct research to incorporate the use of these two interfaces at farm and landscape scale into integrated pest management strategies. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.  相似文献   

Screening a variable germplasm collection of Cucumis melo L. for seedling resistance to Macrophomina phaseolina     

Márcia M. Q. Ambrósio  Ana C. A. Dantas  Eva Martínez-Perez  Alexis C. Medeiros  Glauber H. S. Nunes  María Belén Picó 《Euphytica》2015,206(2):287-300

  相似文献   

Nitrate-induced goiter in captive whitespotted bamboo sharks Chilosryllium plagiosum     

Morris AL  Hamlin HJ  Francis-Floyd R  Sheppard BJ  Guillette LJ 《Journal of aquatic animal health》2011,23(2):92-99

Elasmobranch susceptibility to goiter formation in captive environments has been well documented. Until recently, most public aquariums operated under the belief that the etiology of goiter in elasmobranchs was nutritional and specifically caused by insufficient dietary iodine. Recent studies have demonstrated that high environmental nitrate (NO3-N) inhibits the ability of the thyroid gland to utilize available iodide, resulting in thyroid gland overstimulation by thyroid stimulating hormone and ultimately leading to the development of goiter. The objective of this study was to evaluate the effects of high environmental nitrate concentrations on thyroid function in juvenile whitespotted bamboo sharks Chiloscyllium plagiosum. In July 2008, five juveniles (80-150 g) were exposed to a low-nitrate environment (NO3-N concentration < 1 mg/L of water) and five were exposed to an elevated-nitrate environment (NO3-N = 70 mg/L) for 29 d in a flow-through natural seawater system. Nitrate exposure did not affect growth rates (e.g., weight, length, and condition factor) and did not alter free plasma thyroxine concentrations during the 29-d experimental period. However, histological examination of thyroid glands from sharks exposed to elevated nitrate revealed the development of diffuse hyperplastic goiter. With increasing restrictions on water use, most modern aquaria operate as recirculating systems, which results in higher and more chronic nitrate exposure for captive animals. Goiter is one of the most common health problems in captive elasmobranchs, and this study suggests that nitrate exposure is an important factor in the etiology of this disease.  相似文献   

Characterisation of gastrointestinal helminths and their impact in commercial small-scale chicken flocks in the Mekong Delta of Vietnam     

Van  Nguyen T. B.  Cuong  Nguyen V.  Yen  Nguyen T.P.  Nhi  Nguyen T. H.  Kiet  Bach Tuan  Hoang  Nguyen V.  Hien  Vo B.  Thwaites  Guy  Carrique-Mas  Juan J.  Ribas  Alexis 《Tropical animal health and production》2020,52(1):53-62

Tropical Animal Health and Production - Commercial small-scale chicken farms managed as all-in-all-out but operating with low standards of hygiene/biosecurity are increasingly common in Vietnam....  相似文献