Diffusion kinetics of samarium and neodymium in garnet, and a method for determining cooling rates of rocks     

J Ganguly  M Tirone  RL Hervig 《Science (New York, N.Y.)》1998,281(5378):805-807

Experimental determinations of the diffusion coefficients of samarium and neodymium in almandine garnet and theoretical considerations show that one cannot assign a sufficiently restricted range of closure temperature, TC, to the samarium-neodymium decay system in garnet for the purpose of constraining the cooling rate. However, it is shown that the samarium-neodymium cooling age of garnet can be used to calculate both cooling rate and TC if the temperature and age at the peak metamorphic conditions are known.  相似文献   

Swiss veterinary drug compendium as a tool for reconversions     

Demuth DC  Stucki F  Gassner B  Zinsli S  Müntener C  Althaus FR 《Schweizer Archiv für Tierheilkunde》2006,148(8):397-400, 402-4

The new Swiss ordinance on veterinary drugs poses a new challenge to the veterinarians, specially those working with farm animals. A complete overview about the registered veterinary drugs and immunobiologicals is absolutely necessary to cope with these new tasks: the internet version of the Swiss Veterinary Drug Compendium is a versatile tool to satisfy this needs (http://www.tierarzneimittel.ch). Due to the frequent updates and powerful search possibilities, this database is a reliable and comprehensive information system regarding Swiss veterinary drugs. We will demonstrate how this system can be used as a valuable help in the case of reconversions of drugs (e.g. use of small animal drugs in farm animals).  相似文献   

Pharmacovigilance for veterinary drugs in Switzerland     

Müntener CR  Gassner B  Demuth DC  Althaus FR  Zwahlen R 《Schweizer Archiv für Tierheilkunde》2004,146(11):499-505

Pharmacovigilance is a system concerned with the acquisition, evaluation and classification of informations about suspected adverse drug reactions (SADR). Such a system was developed in Switzerland under the supervision of Swissmedic after the introduction of the federal law on therapeutic products on January 1st 2002. By sending declarations about SADRs, veterinary practitioners play a central role in this scheme. The reports are processed according to international standards (ABON) and provide useful hints to enhance the safety of drug usage by both patients and owners. The system acquired 58 reports in its first complete year of operation (2003). Analysis of these reveals that trends observed in foreign countries are also applicable to Switzerland: most of the reports concerned the use of antiparasitic or antibiotic drugs in small animals. The first year also revealed a high percentage of declarations coming from the pharmaceutical companies and the authors would therefore like to encourage practitioners to take a more active part in this scheme.  相似文献   

Cloning and sequencing of a cDNA expressing a ribosomal P0 peptide from Culicoides nubeculosus (Diptera)     

Althaus H  Müller N  Busato A  Mellor PS  Torsteinsdottir S  Marti E 《Veterinary immunology and immunopathology》2004,99(1-2):99-111

Insect bite dermal hypersensitivity (IBH) is an allergic dermatitis of horses caused by bites of Culicoides spp. and sometimes Simulium spp. The aim of the investigation presented here was to identify allergens causing IBH. A cDNA library expressing recombinant Culicoides nubeculosus proteins was screened using affinity-purified serum from an IBH-affected horse. Screening of the library resulted in identification of one immunoreactive clone. The sequence of the cDNA insert was determined and revealed a 600 bp insert with an open reading frame coding for a 78 amino acid long protein, called rCul n 1. Analysis of the deduced amino acid sequence revealed an identity of 67-78% to the C-terminal part of the 318 amino acid long ribosomal P0 protein from other Diptera. Furthermore, the 38 C-terminal amino acids displayed an identity of 57% with the C-terminal part of the acidic ribosomal protein P2 from Aspergillus fumigatus. The cDNA insert was subcloned and expressed as a [His]6-tagged protein in Escherichia coli and purified using Ni2(+)-chelate affinity chromatography. The 10kDa recombinant Cul n 1 protein bound the affinity-purified antibody fraction used for screening the expression library. Determination of IgE and IgG levels against rCul n 1 by ELISA in sera from 19 IBH-affected and 18 Swiss control horses and in sera from eight control horses living in Iceland showed no significant differences between the three groups of horses (median IgE levels = 60, 49 and 44 relative ELISA units, respectively). rCul n 1 did not induce sulfidoleukotriene (sLT) release from peripheral blood leukocytes of IBH-affected horses (N = 5), although sLT release was induced with the Culicoides whole body extract.  相似文献   

Computer-supported poisonous plant information system for veterinary medicine     

Furler M  Demuth D  Althaus FR  Nägeli H 《Schweizer Archiv für Tierheilkunde》2000,142(6):323-331

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The sterility and productivity of young, short scrotum, Merino rams     

PW MORCOMBE  RL PEET  SJ BELL 《Australian veterinary journal》1990,67(6):235-236

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A Review of Canine Pseudocyesis     

C Gobello  RL de la Sota  & RG Goya 《Reproduction in domestic animals》2001,36(6):283-288

The purpose of this article is to review the most relevant features of the physiology, clinical signs, diagnosis, treatment and prevention of canine pseudocyesis (PSC). This is a physiological syndrome, characterized by clinical signs such as: nesting, weight gain, mammary enlargement, lactation and maternal behaviour, which appears in non‐pregnant bitches at the end of metaoestrus. PSC is a frequent finding in domestic dogs. Although it is generally admitted that prolactin (PRL) plays a central role in the appearance of PSC, its precise aetiophysiology is not completely understood yet. A number of clinical studies suggest that at some point of metaoestrus circulating PRL levels rise in overtly pseudopregnant bitches. Individual differences in sensitivity to PRL as well as the existence of molecular variants of canine PRL with different bioactivity versus immunoreactivity ratios may help clarify the aetiopathology of PSC. Diagnosis of PSC is based on the presence of typical clinical signs in metaoestrous non‐pregnant bitches. Considering that PSC is a self limiting physiological state, mild cases usually need no treatment. Discouraging maternal behaviour and sometimes fitting Elizabethan collars to prevent licking of the mammary glands may suffice in these cases. Sex steroids (oestrogens, progestins and androgens) have been traditionally used to treat PSC but the side‐effects usually outweigh the benefits of these medications. Inhibition of PRL release by ergot derivatives [ bromocriptine (10–100 μg/kg per day for 10–14 days], cabergoline (5 μg/kg per day during 5–10 days), metergoline (0.2 mg/kg per day during 8–10 days) has proved to be effective for the treatment of canine PSC. Although some of these ergot derivatives present some untoward side‐effects, they are transient and can usually be managed. Predisposed bitches not intended for breeding should be spayed as ovariectomy is the only permanent preventive measure.  相似文献   

Congenital joint laxity and dwarfism in calves     

RL PEET  J. CREEPER 《Australian veterinary journal》1994,71(2):58-58

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Chlamydiosis in commercial ducks   总被引：1，自引：0，他引：1  

KE ARZEY  GG ARZEY  RL REECE 《Australian veterinary journal》1990,67(9):333-334

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Reduced growth of Lucilia cuprina larvae fed serum from sheep treated with anthelmintics     

IJ EAST  RL KERLIN  CH EISEMANN 《Australian veterinary journal》1992,69(11):286-287

The effect of three commonly used anthelmintics, levamisole hydrochloride, ivermectin and closantel, on the development of the sheep blowfly, Lucilia cuprina, was determined. Sheep were treated with each anthelmintic using the manufacturers' recommended dose for helminth control. Both ivermectin and closantel significantly (p < 0.05) reduced the growth rate of larvae of L cuprina cultured in vitro on serum from these sheep. Levamisole hydrochloride had no effect. Ivermectin was effective for less than 6 days after treatment, whereas closantel significantly reduced larval growth 21 days after treatment. Dose-response experiments showed that lower concentrations of both ivermectin and closantel were not as effective in reducing larval growth.  相似文献