Malignant pheochromocytoma presenting as a bradyarrhythmia in a dog     

Andrew J. Brown  MA  VetMB  DACVECC  MRCVS    Amy J. Alwood  DVM    Steven G. Cole DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2007,17(2):164-169

Objective: To describe a case of atrioventricular block and syncope secondary to systemic hypertension in a dog with malignant pheochromocytoma. Case Summary: A 13‐year‐old spayed female mixed‐breed dog presented following an acute onset of collapse. The dog was hypertensive and had paradoxical high‐grade second‐degree atrioventricular block with concurrent syncope. Initial emergent therapy included a nitroprusside infusion for the systemic hypertension and vagolytic therapy for the bradyarrhythmia. A left adrenal mass was seen on abdominal ultrasound and was further characterized by MRI. Following medical stabilization with phenoxybenzamine and propantheline, a left adrenalectomy was performed. Histological diagnosis was consistent with a malignant pheochromocytoma. Following tumor removal there has been no further hypertension, atrioventricular block or syncope. Unique information provided: This is the first documented case of a malignant pheochromocytoma presenting as syncope secondary to hypertension induced atrioventricular block.  相似文献   

Acute respiratory distress syndrome in dogs and cats: a review of clinical findings and pathophysiology     

Amy E. DeClue  DVM  MS  DACVIM    Leah A. Cohn  DVM  PhD  DACVIM 《Journal of Veterinary Emergency and Critical Care》2007,17(4):340-347

Objective: To review the clinical and pathophysiologic aspects of acute respiratory distress syndrome (ARDS) in dogs and cats. Data sources: Data from human and veterinary literature were reviewed through Medline and CAB as well as manual search of references listed in articles pertaining to acute lung injury (ALI)/ARDS. Human data synthesis: Since the term ARDS was first coined in 1967, there has been a abundance of literature pertaining to this devastating syndrome in human medicine. More complete understanding of the complex interactions between inflammatory cells, soluble mediators (e.g., tumor necrosis factor, interleukin (IL)‐6, IL‐8, platelet activating factor) and the clinical patient has provided for timely recognition and mechanistically based protective strategies decreasing morbidity and mortality in human patients with ARDS. Veterinary data synthesis: Although little is known, ARDS is becoming a more commonly recognized sequela in small animals. Initial case reports and retrospective studies have provided basic clinical characterization of ARDS in dogs and cats. Additionally, information from experimental models has expanded our understanding of the inflammatory mechanisms involved. It appears that the inflammatory processes and pathologic changes associated with ARDS are similar in dogs, cats, and humans. Conclusions: Unfortunately, current mortality rates for ARDS in small animals are close to 100%. As our capability to treat patients with advanced life‐threatening disease increases, it is vital that we develop a familiarity with the pathogenesis of ARDS. Understanding the complex inflammatory interactions is essential for determining effective preventative and management strategies as well as designing novel therapies for veterinary patients.  相似文献   

Affinity of detomidine, medetomidine and xylazine for alpha-2 adrenergic receptor subtypes     

D.D. Schwartz  & T.P. Clark 《Journal of veterinary pharmacology and therapeutics》1998,21(2):107-111

α₂-Adrenergic receptor agonists are widely used in veterinary medicine as sedative/hypnotic agents. Four pharmacological subtypes of the α₂-adrenergic receptor (A, B, C and D) have been identified based primarily on differences in affinity for several drugs. The purpose of this study was to examine the affinities of the sedative agents, xylazine, detomidine and medetomidine at the four α₂-adrenergic receptor subtypes. Saturation and inhibition binding curves were performed in membranes of tissues containing only one subtype of a₂-adrenergic receptor. The K_D for the α₂-adrenergic receptor radioligand, [³H]-MK-912, in HT29 cells (α_2A-), neonatal rat lung (α_2B-), OK cells (α_2C-) and PC12 cells transfected with RG20 (α_2D-) were 0.38 ± 0.08 n m , 0.70 ± 0.5 n m , 0.07 ± 0.02 n m and 0.87 ± 0.03 n m , respectively. Detomidine and medetomidine had approximately a 100 fold higher affinity for all the α₂-adrenergic receptors compared to xylazine but neither agonist displayed selectivity for the α₂-adrenergic receptor subtypes. These data suggest that available sedative/hypnotic α₂-adrenergic receptor agonists can not discriminate between the four known α₂-adrenergic receptor subtypes.  相似文献   

A Syndrome Resembling Idiopathic Noncirrhotic Portal Hypertension in 4 Young Doberman Pinschers   总被引：1，自引：0，他引：1  

JoAnn DeMarco  Sharon A. Center  Nathan Dykes  Amy E. Yeager  Bruce Kornreich  Ed Gschrey  Kelly A. Credille  Magali Guffroy  Fabio del  Piero Beth A. Valentine 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》1998,12(3):147-156

We describe 4 young male Doberman Pinschers (3 littermates and 1 unrelated dog) with a syndrome resembling idiopathic or noncirrhotic portal hypertension of humans. Each dog was evaluated for a hepatopathy resulting in portal hypertension, development of portosystemic collateral vessels, and hepatic encephalopathy. These dogs differ from previous reports of young dogs with hepatic insufficiency associated with portal hypertension and acquired portal systemic shunting by their lack of intrahepatic arteriovenous fistulae, portal vein atresia, or intrahepatic fibrosis. Clinicopathologic features included erythrocyte microcytosis, normal to mildly increased liver enzyme activities, increased concentrations of serum bile acids, reduced plasma indocyanine green clearance, and normal total bilirubin concentration. Abdominal ultrasonography disclosed a small liver and portosystemic collateral vessels. Radiographic imaging studies confirmed hepatofugal portal circulation and discounted hepatic arteriovenous fistulae. Histopathologic features in liver tissue from each dog were similar and consistent in all sections examined. Common findings included increased cross-sectional views of hepatic arterioles; hepatic lobular atrophy; scanty increase in connective tissue around some large portal triads; and absence of inflammation, disturbed lobular architecture, bile duct proliferation, or intrahepatic cholestasis.  相似文献   

Maria Fonte and Apostolos G. Papadopoulos (eds): Naming food after places: food relocalisation and knowledge dynamics in rural development     

Amy E. Snively-Martinez 《Agriculture and Human Values》2012,29(1):129-130

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Tree planting in Tigray, Ethiopia: the importance of human disease and water microdams     

Gregory S. Amacher  Lire Ersado  William F. Hyde  Amy Osorio 《Agroforestry Systems》2004,60(3):211-225

We examine the decision to plant trees and level of tree planting for two sites, public microdam areas and household agricultural land, and two species groups in Tigray, Ethiopia. Both sites are not perfect substitutes, as they vary with respect to distance from the household and tenure security. The role of permanent pooled water irrigation microdams to tree planting is important but unknown, because water borne diseases, which may influence household income and productivity, are thought to be enhanced by the dams. We find both disease and microdams to be important predictors to tree planting. Disease seems more important in determining whether households plant at all, and less important in the level of planting for those that do plant. For example, disease increases the probability of planting both eucalyptus and other species groups on household-own land, but households suffering from malaria plant higher-cost eucalyptus trees with lower probability at both sites, while planting of other lower-cost species increases at dam sites where other villagers can monitor the trees. We also establish a connection between planting and agricultural residues, finding a strong substitution effect on own-land. Microdam access and age are also important. Households living nearer to dam sites will plant both species groups there with higher probabilities, but the decision to plant on agricultural own-land is not affected. For older dams with more developed irrigation, households are more likely to grow crops rather than plant trees on their own land, but they plant more trees at the dam sites. This revised version was published online in June 2006 with corrections to the Cover Date.  相似文献   

Primary pulmonary neoplasia in cats: assessment of computed tomography findings and survival          下载免费PDF全文

J. Nunley  J. Sutton  W. Culp  D. Wilson  K. Coleman  R. Demianiuk  A. Schechter  G. Moore  T. Donovan  P. Schwartz 《The Journal of small animal practice》2015,56(11):651-656

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Effect of sorbitol,single, and multidose activated charcoal administration on carprofen absorption following experimental overdose in dogs          下载免费PDF全文

Amy M. Koenigshof DVM  MS  DACVECC  Matthew W. Beal DVM  DACVECC  Robert H. Poppenga DVM  PhD  DABVT  L. Ari Jutkowitz VMD  DACVECC 《Journal of Veterinary Emergency and Critical Care》2015,25(5):606-610

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Prospective evaluation of the incidence of wound infection in rattlesnake envenomation in dogs          下载免费PDF全文

Amy Carr DVM  DACVECC  Jennifer Schultz DVM 《Journal of Veterinary Emergency and Critical Care》2015,25(4):546-551

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Effects of growing conditions on purple corncob (Zea mays L.) anthocyanins     

Jing P  Noriega V  Schwartz SJ  Giusti MM 《Journal of agricultural and food chemistry》2007,55(21):8625-8629

Purple corn ( Zea mays L.) has been used for centuries as a natural food colorant in South America and, more recently, in Asia and Europe. However, limited information is available on the factors affecting their anthocyanin concentration and profiles. In this study, 18 purple corn samples grown under different conditions in Peru were evaluated for quantitative and qualitative anthocyanin composition as well as total phenolics. High variability was observed on monomeric anthocyanin and phenolic contents with yields ranging from 290 to 1333 mg/100 g dry weight (DW) and from 950 to 3516 mg/100 g DW, respectively, while 30.5-47.1% of the total phenolics were anthocyanins. The major anthocyanins present were cyanidin-3-glucoside, pelargonidin-3-glucoside, peonidin-3-glucoside, cyanidin-3-maloylglucoside, pelargonidin-3-maloylglucoside, and peonidin-3-maloylglucoside, and 35.6-54.0% of the anthocyanins were acylated. Potassium sources/concentrations on the soil and seedling density did not significantly affect anthocyanin composition. The growing location affected anthocyanin levels and the percentage of anthocyanins to total phenolics ( p < 0.01) and should be taken into account when choosing a material for color production.  相似文献