Effect of thyroid hormone supplementation on survival of euthyroid dogs with congestive heart failure due to systolic myocardial dysfunction: a double-blind, placebo-controlled trial     

Tidholm A  Falk T  Gundler S  Svensson H  Ablad B  Sylvén C 《Research in veterinary science》2003,75(3):195-201

Nineteen euthyroid dogs of 12 breeds with echocardiographic signs of dilated cardiomyopathy (DCM) and radiographic and clinical signs of congestive heart failure (CHF) were evaluated in a randomised, double-blind, and placebo-controlled study. The dogs received either thyroxine or placebo as an adjunct to digoxin, furosemide and propranolol. The group assignment of individual dogs and serum concentrations of thyroid hormones remained unknown to owners and investigators during the entire study period. Dogs were evaluated clinically and with electrocardiography (ECG), thoracic radiography, echocardiography and measurement of total thyroxine (tT4) and thyroid stimulating hormone (TSH) before beginning of the trial, and then one week, 2 months, 6 months and yearly after initial examination, and, when applicable, at the time of euthanasia. End-point of the study was euthanasia (n = 17) due to severe congestive heart failure or sudden death (n = 2). Survival times ranged from 17 to 1030 days (median 187 days) in the placebo group, and from 18 to 1000 days (median 73 days) in the treatment group. There was no statistically significant difference in survival times between the treatment group and the placebo group (p = 0.46). Post mortem and histopathologic examinations revealed the attenuated wavy fiber type of DCM in 11 dogs, and myocardial infarcts, arteriosclerosis and chronic valvular disease in one dog. In conclusion, there was a wide range in survival times of dogs treated with digoxin, furosemide and propranolol. Adding thyroid hormones to the treatment did not significantly influence survival.  相似文献   

Dog castration abroad     

Deen A  Jongsma-Biben Y  van Gisbergen R 《Tijdschrift voor diergeneeskunde》2003,128(3):92

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BVDV: 40 years of effort and the disease still has a firm hold     

O'Rourke K 《Journal of the American Veterinary Medical Association》2002,220(12):1770-1773

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Occurrence of the temperature-sensitive hemagglutinin among avian Escherichia coli     

Delicato ER  de Brito BG  Konopatzki AP  Gaziri LC  Vidotto MC 《Avian diseases》2002,46(3):713-716

In this study, we determined the occurrence of the tsh gene among 305 Escherichia coli isolates from chickens by means of the polymerase chain reaction and agglutination of chicken erythrocytes; 200 of those isolates were obtained from chickens with colisepticemia, 52 isolates were from lesions of cellulitis, and 53 were from feces of normal chickens. The tsh gene was found in 79 (39.5%) isolates from colisepticemia, in 10 (19%) cellulitis-derived E. coli isolates, and in two (3.8%) fecal isolates. Among the tsh+ strains, 68 (86%) isolates from colisepticemia and nine (90%) from cellulitis agglutinated chicken erythrocytes in the presence of mannose, after growing the strains on colonization factor antigen agar plates at 26 C, which confirms a correlation between mannose-resistant hemagglutination and expression of hemagglutinin Tsh. These results show, for the first time, the presence of the gene tsh in cellulitis-derived E. coli isolates; the high frequency of this gene among avian pathogenic E. coli isolates in Brazil indicates that its putative role as a virulence factor should be studied more thoroughly.  相似文献   

What is your diagnosis? Displaced avulsion fracture of the basisphenoid-basioccipital bone     

Alexander K  Baird JD  Dobson H  Parsons DA 《Journal of the American Veterinary Medical Association》2002,220(3):297-298

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Is the carbon-copy cat causing questions from your clients?     

O'Rourke K 《Journal of the American Veterinary Medical Association》2002,220(7):949-950

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What's in the water?     

O'Rourke K 《Journal of the American Veterinary Medical Association》2002,221(1):16

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Communicating in a crisis: making the best of a bad situation     

O'Rourke K 《Journal of the American Veterinary Medical Association》2002,220(5):580

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The neurological examination and lesion localization in the companion rabbit (Oryctolagus cuniculus).     

Karen M Vernau  Anna Osofsky  Richard A LeCouteur 《Veterinary Clinics of North America: Exotic Animal Practice》2007,10(3):731-58, v

Completion of a thorough neurological examination of a rabbit is essential for clinicians to determine the location of a neurological problem. Determination of the location of a lesion (whether solitary or multifocal/diffuse) enables a clinician to list the most likely causes of the problem. This article presents the neurological examination of the rabbit, followed by a practical guide to lesion localization in this species.  相似文献   

Perspectives and advances in in-clinic laboratory diagnostic capabilities: hematology and clinical chemistry.     

M Glade Weiser  Linda M Vap  Mary Anna Thrall 《Veterinary Clinics of North America: Small Animal Practice》2007,37(2):221-36, v

The typical technologies used in veterinary hematology and biochemical analyzers are reviewed, along with associated advantages and disadvantages. Guidelines for implementing a successful in-clinic laboratory are provided, including criteria for system evaluation and expectations for comparative performance evaluations. The more common problems and limitations associated with in-clinic laboratory diagnostics and how to best prevent them are also discussed.  相似文献