Congenital lacrimal fistula in two prim'Holstein calves     

Sophie Jugant  Marie‐Claire Robin  Alain Regnier  Herv Cassard  Nicolas Herman  Fabrice Conchou  Jean‐Yves Douet 《Veterinary ophthalmology》2019,22(3):368-373

Two 4‐ and 8‐month‐old prim'Holstein calves were presented for chronic epiphora. Examination of the affected eyes revealed an abnormal duct opening inferonasal to the medial canthus. A diagnosis of congenital lacrimal fistula was made based on conventional and computed tomographic‐dacryocystography findings. These revealed an ectopic channel connecting the nasolacrimal duct to the skin opening near the medial canthus. Both of the calves were surgically treated with resection and closure of the ectopic duct and placement of a nasolacrimal stent.  相似文献   

Effect of supplementation with n-3 polyunsaturated fatty acids and/or β-glucans on performance,feeding behaviour and immune status of Holstein Friesian bull calves during the pre-and post-weaning periods     

Ruairi P.McDonnell  John V.O' Doherty  Bernadette Earley  Anne Marie Clarke  David A.Kenny 《畜牧与生物技术杂志(英文版)》2019,(2)

Background: Previous research in both calves and other species has suggested n-3 polyunsaturated fatty acids(PUFA) and β-glucans may have positive effects on immune function. This experiment measured performance,behaviour, metabolite and immunological responses to pre-weaning supplementation of dairy bull calves with n-3 PUFA in the form of fish oil and β-glucans derived from seaweed extract. 44 Holstein Friesian bull calves, aged 13.7± 2.5 d and weighing 48.0 ± 5.8 kg were artificially reared using an electronic feeding system. Each calf was offered5 L(120 g/L) per day of milk replacer(MR) and assigned to one of four treatments included in the MR,(1) Control(CON);(2) 40 g n-3 PUFA per day(FO);(3) 1 g β-glucans per day(GL) and(4) 40 g n-3 PUFA per day 1 g/d β-glucans(FOGL) in a 2 × 2 factorial design. Milk replacer and concentrate was offered from d 0–62(pre-weaning),while concentrate provision continued for a further 31 d post-weaning period. Individual daily feed intake and feeding behaviour was recorded throughout, while bodyweight and blood analyte data were collected at regular intervals.Results: Overall mean concentrate DMI from d 0–93 was 1.39, 1.27, 1.00 and 0.72 kg/d for CON, FO, GL and FOGL calves, respectively(SEM = 0.037; P 0.0001). Calves supplemented with GL were significantly lighter(P 0.0001) at both weaning(d 62) and turnout to pasture(d 93) than un-supplemented calves, with a similar effect(P 0.0001)evident for calves receiving FO compared to un-supplemented contemporaries. Supplementation with GL reduced the number of unrewarded visits where milk was not consumed(P 0.0001) while supplementation with FO increased mean drinking speed(P 0.0001). Supplementation with GL resulted in greater concentrations of haptoglobin(P = 0.034), greater serum osmolality(P = 0.021) and lower lymphocyte levels(P = 0.027). In addition,cells from GL supplemented calves exhibited a lower response than un-supplemented contemporaries to both Phytohaemagglutinin A stimulated IFN-γ(P = 0.019) and Concanavalin A stimulated IFN-γ(P = 0.012) following in vitro challenges.Conclusions: Pre-weaning supplementation of bull calves with either n-3 PUFA or β-glucan resulted in reduced voluntary feed intake of concentrate and consequently poorer pre-weaning calf performance. There was no evidence for any beneficial effect of either supplementation strategy on calves' immune responses.  相似文献   

Despite high‐risk exposures,no evidence of zoonotic transmission during a canine outbreak of leptospirosis     

Sarah Anne J. Guagliardo  Sally Ann Iverson  Laura Reynolds  Hayley Yaglom  Heather Venkat  Renee Galloway  Craig Levy  Alison Reindel  Tammy Sylvester  Melissa Kretschmer  Margaret LaFerla Jenni  Peter Woodward  Norman Beatty  Aileen Artus  Ronald Klein  Rebecca Sunenshine  Ilana J. Schafer 《Zoonoses and public health》2019,66(2):223-231

Leptospirosis is a bacterial zoonosis that affects many mammals, including humans and dogs; dogs can transmit the bacteria to humans, but the frequency of transmission and highest risk exposures are poorly understood. During 2016–2017, the Maricopa County Department of Public Health, Arizona Department of Health Services and Centers for Disease Control and Prevention investigated the zoonotic potential of a canine leptospirosis outbreak in the Phoenix metro area. We identified symptomatic persons exposed to canine leptospirosis cases by conducting active and passive surveillance. We tested dog owners (n = 9) and animal care providers (n = 109) for serological evidence of Leptospira spp. infection (via the microscopic agglutination test [MAT]) and interviewed these persons about their specific exposures to canine cases and general exposures to canine blood and urine. Through surveillance, seven symptomatic persons were identified; six were tested and all were negative by MAT, and of these six, four persons were negative by PCR (two did not have PCR testing). All serosurvey participants (n = 118) were also seronegative. Among animal care providers, bare skin contact with urine/blood from a canine case was reported by 23.2%; two persons reported dog urine splashing in their face. Veterinary technicians were more likely to have bare skin contact with blood from a canine case compared to veterinarians and boarding facility staff (p < 0.001). Infection control practices were inconsistent; when working with specimens from a canine leptospirosis case, 44.6% of participants reported always wearing gloves when working with urine (i.e., collecting specimens), and 54.5% always wore gloves when working with blood. Veterinary technicians were also most likely to engage in all activities involving potential urine/blood contact, such as conducting laboratory tests (p < 0.01). We therefore recommend that veterinary technicians specifically receive targeted education about infection control practices. Our results suggest that dog‐to‐human transmission of leptospirosis is uncommon.  相似文献   

Investigation of a community cluster of cutaneous Mycobacterium marinum infection,an emerging zoonotic pathogen in aquaculture industry,Haliburton, Kawartha,Pine Ridge District Health Unit,Ontario, Canada,July–August 2015     

Vidya Sunil  Andrew W. Harris  Bob Sine  Anne Marie Holt  A. Lynn Noseworthy  Doug Sider  Frances B Jamieson  Shelley White  Cassandra Johnston  Olivia Spohn 《Zoonoses and public health》2019,66(1):164-168

In July 2015, a cluster of five suspect cases of clinically diagnosed Mycobacterium marinum (M. marinum) skin infections were reported to the Haliburton, Kawartha, Pine Ridge District Health Unit (HKPRDHU), Ontario, Canada, with two additional cases subsequently identified through case finding. All seven cases presented with cutaneous lesions located on the finger, hand and/or elbow regions typical of M. marinum infection. Specimens were collected by skin biopsy for two of the seven cases; both cases tested positive for M. marinum by molecular detection (hsp65 gene amplification and sequencing), and one was confirmed positive for M. marinum by culture. All seven cases reported handling raw shrimp from an aquaculture facility in the Health Unit's jurisdiction. M. marinum is not a reportable disease in Ontario, and there are no known previous reports of a cluster of M. marinum reported in Ontario, Canada. A cluster investigation working group was struck that included representation from various agencies including Public Health Ontario (PHO), Public Health Ontario Laboratories (PHOL), Ontario Ministry of Agriculture and Rural Affairs (OMAFRA) and the two health units involved in case investigations. Several public health and aquaculture farming recommendations were made to mitigate further risks associated with handling of raw shrimp from the facility. Several challenges were faced during the investigation process. The paper discusses these challenges and public health recommendations made in order to mitigate occupational and public health risks related to the hazard identified.  相似文献   

Cover Image,Volume 66, Issue 5     

Nídia S. Trovo  Frances K. Shepherd  Katerina Herzberg  Matthew C. Jarvis  Ham C. Lam  Albert Rovira  Marie R. Culhane  Martha I. Nelson  Douglas G. Marthaler 《Zoonoses and public health》2019,66(5):i-i

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Validation and method comparison of the use of densitometry to quantify monoclonal proteins in canine sera     

Adam Dugger Harris  Emily Rout  Anne Avery  Denise Bolte  Erica Belling‐Kelly  A Russell Moore 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2019,48(Z1):78-87

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Analytical performance of canine acylated and unacylated ghrelin enzyme‐linked immunosorbent assays     

Julie Lass  Mette L. Nielsen  Charlotte R. Bjrnvad  Anne D. Vitger  Signe E. Cremer 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2019,48(4):748-753

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Interpretative considerations for clinical pathology findings in nonclinical toxicology studies     

Adam Aulbach  Allison Vitsky  Tara Arndt  Lila Ramaiah  Michael Logan  William Siska  Laura Cregar  Niraj Tripathi  Adeyemi Adedeji  Anne Provencher  Ara Gupta  Holly Jordan  Denise Bounous  Laura Boone 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2019,48(3):383-388

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Genetic cause for congenital methemoglobinemia in an Australian Pomeranian dog     

Shijia Zhou  Rick Tearle  Raziallah Jafari Jozani  Bethany Winra  Olaf Schaaf  Anthony Nicholson  Anne Peaston 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(2):868-873

Little is known about genetic causes of congenital methemoglobinemia in dogs. Here, we report a CYB₅R₃ mutation in a Pomeranian dog with congenital methemoglobinemia. A 6‐year‐old neutered female Pomeranian dog was investigated for cyanosis noticed during anesthesia for an orthopedic procedure. The history included lifelong mild exercise intolerance and bluish tongue. Methemoglobinemia was diagnosed using co‐oximetry. The CYB₅R₃ gene was analyzed by comparing the patient's genomic DNA with the reference canine sequence. Mutation functional significance was investigated using snpEff and multispecies protein homology analyses. A homozygous missense single nucleotide CYB₅R₃ mutation (ATC ? CTC at codon 194) caused a p.Ile194Leu substitution. The pIle194 residue is highly conserved in other mammals, supporting the likely pathogenicity of the substitution. The mutation described here is identical to that associated with familial methemoglobinemia in a family of Japanese Pomeranian dogs. This observation, together with the homozygous mutation found in our case, indicates that the mutant allele may be widespread within the Pomeranian breed internationally.  相似文献   

Biomarkers of oxidative stress as an assessment of the redox status of the liver in dogs     

Caitlin Barry‐Heffernan  Joanne Ekena  Sarah Dowling  Marie E. Pinkerton  Katrina Viviano 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(2):611-617

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