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Coddens A Verdonck F Mulinge M Goyvaerts E Miry C Goddeeris B Duchateau L Cox E 《Veterinary microbiology》2008,126(1-3):210-215
F18(+)Escherichia coli infections causing post-weaning diarrhoea and/or oedema disease are a major cause of economic losses in pig industry. To date, no preventive strategy can protect pigs from F18(+)E. coli infections. One of the most attractive approaches to eliminate F18(+)E. coli infections is the selection for pigs that are resistant to F18(+)E. coli infections. However, this strategy was not believed to be favourable because of reports of genetic association with the stress-susceptibility gene in the Swiss Landrace. To investigate this potential association more thoroughly, 131 randomly selected Belgian hybrid pigs were genotyped for both the F18(+)E. coli resistance alleles (FUT1(A)) and the stress-susceptibility alleles (RYR1(T)) and their association was investigated by determining the linkage disequilibrium. This linkage disequilibrium (LD=-0.0149) is close to zero and does not differ significantly from 0 (likelihood ratio test chi(1)(2)=1.123, P=0.29), demonstrating no association between the FUT1(A) and RYR1(T) alleles. Furthermore, only a small fraction (4.6%) of the Belgian pigs was found to be resistant to F18(+)E. coli infections. Our results suggest that selection for F18(+)E. coli resistant pigs might be an attractive approach to prevent pigs from F18(+)E. coli infections, unlike to what has previously been postulated. 相似文献
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Effect of sotalol on heart rate,QT interval,and atrial fibrillation cycle length in horses with atrial fibrillation 
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Judit Viu Lara Armengou Annelies Decloedt Eduard Jose-Cunilleras 《Journal of Veterinary Cardiology》2018,20(3):213-221
Two horses referred to the Unitat Equina, Fundació Hospital Clínic Veterinari, Universitat Autònoma de Barcelona, for unrelated clinical problems, and with no previous history of cardiac disease exhibited an intermittent ventricular pre-excitation electrocardiographic pattern during hospitalization. Both animals showed decreased plasma total and ionized magnesium concentrations, but no other relevant electrolyte disturbances were detected. Altered interventricular septal motion associated with ventricular pre-excitation beats (VPBs) was detected on M-mode echocardiography in both horses. The likely localization of an accessory pathway (AP) was identified in case 2 using pulsed-wave tissue Doppler imaging in the left anterior paraseptal location. Decreased frequency of the VPB was observed with long-term magnesium supplementation and restoration of plasma magnesium concentrations. The presence of ventricular pre-excitation electrocardiographic pattern was attributed to higher sensitivity of the AP to hypomagnesemia in both cases. 相似文献
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Stijn Schauvliege DVM Annelies Van den Eede DVM Luc Duchateau PhD Frederik Pille DVM PhD Diplomate ECVS Lieven Vlaminck DVM PhD Diplomate ECVS Frank Gasthuys DVM PhD Diplomatic ECVAA 《Veterinary anaesthesia and analgesia》2009,36(2):101-109
ObejctiveTo investigate the influence of calcium chloride (CaCl2) on the cardio–respiratory effects of enoximone in isoflurane anaesthetized ponies.Study designProspective consecutive experimental trial.AnimalsSix healthy ponies, weighing 287 ± 55 kg were included in this study.MethodsAfter sedation (romifidine, 80 μg kg?1), anaesthesia was induced with midazolam (0.06 mg kg?1) and ketamine (2.2 mg kg?1) and maintained with isoflurane in oxygen. The ponies’ lungs were ventilated to maintain normocapnia. After 90 minutes, a bolus of enoximone (0.5 mg kg?1) was administered, followed by a CaCl2 infusion (0.5 mg kg?1 minute?1 over 10 minutes) (treatment EC). Sodium, potassium, ionized and total calcium concentrations, cardiovascular variables and blood–gases were measured in the 120 minutes after treatment. Using a mixed model anova, the results were compared to those of a previous report [Vet Anaesth Analg, 34 (2007) 416], evaluating the effects of 0.5 mg kg?1 enoximone in the same ponies and under identical circumstances (treatment E). Both an overall comparison and comparisons at specific time points after treatment were performed (α = 0.05).ResultsAlthough ionized and total calcium concentrations were higher during treatment EC, the cardio–respiratory effects of enoximone were comparable for both treatments. A small but significant difference in packed cell volume was detected.Conclusions and clinical relevanceCalcium chloride did not enhance the effects of enoximone in normocalcaemic anaesthetized ponies. 相似文献
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Annelies Vercauteren Isabelle De Dobbelaere Erik Van Bockstaele Martine Maes Kurt Heungens 《European journal of plant pathology / European Foundation for Plant Pathology》2011,129(4):621-635
Phytophthora ramorum, a recently described North American and European pathogen, has three clonal lineages. The NA1 and NA2 lineages are found
in North American forests and nurseries, while the EU1 lineage appears mainly in European nurseries. P. ramorum is heterothallic, having two mating types A1 and A2. All NA1 and NA2 isolates are of A2 mating type. When first collected,
all EU1 isolates were of A1 mating type, with the exception of one A2 isolate collected in Belgium in 2002. Screening 410
other Belgian isolates for mating type revealed two additional EU1-A2 isolates collected in 2002 and 2003. PCR-RFLP, AFLP
and SSR markers were used to determine the nature of the mating type change. The three isolates show no indications of sexual
recombination or mitotic crossing over, indicating that mutation or mitotic gene conversion is the most likely explanation
for the mating type change. We compared the pathogenicity and sporulation characteristics of the EU1-A2 isolates to those
of EU1-A1 and NA1-A2 isolates on four host plants. Despite small differences in pathogenicity on some hosts, the EU1-A2 isolates
were similarly aggressive to each other and to the EU1-A1 isolates and more aggressive than the NA1-A2 isolates. Sporulation
characteristics were also comparable among EU1-A2 isolates and between EU1-A1 and EU1-A2 isolates, except for EU1-A2 isolate
BBA 26/02. The limited genotypic and phenotypic differences between EU1-A2 isolates probably evolved after the mating type
change, which may have occurred several years before the isolates were detected. There are strong indications that the EU1-A2
population has been eradicated from Belgium. 相似文献
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Annelies Maria Declercq Freddy Haesebrouck Wim Van den Broeck Peter Bossier Annemie Decostere 《Veterinary research》2013,44(1):27
Flavobacterium columnare (F. columnare) is the causative agent of columnaris disease. This bacterium affects both cultured and wild freshwater fish including many susceptible commercially important fish species. F. columnare infections may result in skin lesions, fin erosion and gill necrosis, with a high degree of mortality, leading to severe economic losses. Especially in the last decade, various research groups have performed studies aimed at elucidating the pathogenesis of columnaris disease, leading to significant progress in defining the complex interactions between the organism and its host. Despite these efforts, the pathogenesis of columnaris disease hitherto largely remains unclear, compromising the further development of efficient curative and preventive measures to combat this disease. Besides elaborating on the agent and the disease it causes, this review aims to summarize these pathogenesis data emphasizing the areas meriting further investigation. 相似文献
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Luciana Rossi Alessia Di Giancamillo Serena Reggi Cinzia Domeneghini Antonella Baldi Vittorio Sala Vittorio Dell'Orto Annelies Coddens Eric Cox Corrado Fogher 《Journal of veterinary science (Suw?n-si, Korea)》2013,14(3):263-270
Verocytotoxic Escherichia (E.) coli strains are responsible for swine oedema disease, which is an enterotoxaemia that causes economic losses in the pig industry. The production of a vaccine for oral administration in transgenic seeds could be an efficient system to stimulate local immunity. This study was conducted to transform tobacco plants for the seed-specific expression of antigenic proteins from a porcine verocytotoxic E. coli strain. Parameters related to an immunological response and possible adverse effects on the oral administration of obtained tobacco seeds were evaluated in a mouse model. Tobacco was transformed via Agrobacteium tumefaciens with chimeric constructs containing structural parts of the major subunit FedA of the F18 adhesive fimbriae and VT2e B-subunit genes under control of a seed specific GLOB promoter. We showed that the foreign Vt2e-B and F18 genes were stably accumulated in storage tissue by the immunostaining method. In addition, Balb-C mice receiving transgenic tobacco seeds via the oral route showed a significant increase in IgA-positive plasma cell presence in tunica propria when compared to the control group with no observed adverse effects. Our findings encourage future studies focusing on swine for evaluation of the protective effects of transformed tobacco seeds against E. coli infection. 相似文献