Duration of the persistent activity of moxidectin against Haemonchus contortus in sheep     

KA ABBOTT  RM COBB†  M HOLM GLASS† 《Australian veterinary journal》1995,72(11):408-410

SUMMARY Weaned lambs were infected with Haemonchus contortus 35,28,21,14 and 7 days after treatment with moxidectin at 0.2 mg/kg and 35 and 14 days after treatment with ivermectin at the same dose rate. Worm counts 14 days after infection showed that moxidectin prevented the establishment of over 99% of infective larvae for 28 days and reduced the establishment rate at 35 days by 96%, relative to ivermectin. There was no difference in the protective efficacy of ivermectin at 14 or 35 days. The persistence of moxidectin is likely to provide advantages in nematode control, particularly when used as a strategic early summer treatment or as a pre-lambing treatment to ewes. Implications of the persistent activity of moxidectin for the development of resistance during the decay phase are discussed.  相似文献   

Observations on the endo- and ectoparasites affecting dogs and cats in Aboriginal communities in the north-west of Western Australia   总被引：1，自引：1，他引：0  

RCA THOMPSON  BP MELONI  RM HOPKINS  P DEPLAZES  JA REYNOLDSON 《Australian veterinary journal》1993,70(7):268-270

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Cutaneous pythiosis in beef calves   总被引：3，自引：0，他引：3  

R I Miller  B M Olcott  M Archer 《Journal of the American Veterinary Medical Association》1985,186(9):984-986

Six Brahman and Brahman-cross calves less than or equal to 9 months old were examined because of ulcerative swellings of the fetlocks (5 calves) or numerous focal ulcerated cutaneous lesions (1 calf). Biopsies revealed focal cutaneous granulomas around regular, thick-walled branching hyphae, 4 to 9 micron in diameter. In all cases, portions of the hyphae were surrounded by granular encrustations, which ultrastructurally were composed of amorphous material comparable to antigen-antibody complexes. The protist Pythium sp was isolated from 2 calves.  相似文献   

Antebrachiometacarpal arthrodesis in five dogs     

ST Lewis  DD Lewis  AR Cross  RM Radasch  C Boekhout‐Ta 《Australian veterinary journal》2019,97(4):122-127

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Alterations in activated T‐cell cytokine expression in healthy dogs over the initial 7 days of twice daily dosing with oral cyclosporine     

Caitlin Riggs  Lakshmi Narayanan  Charlee Mulligan  Robert Wills  Andrew Mackin  Claire Fellman  John Thomason  Todd Archer 《Journal of veterinary pharmacology and therapeutics》2019,42(4):385-391

Cyclosporine is a powerful T‐cell inhibitor used in the treatment of immune‐mediated and inflammatory diseases in the dog. There is limited information on how to best monitor patients on cyclosporine therapy. Currently, pharmacokinetic and pharmacodynamic assays are available. Pharmacokinetic assays that measure the concentration of cyclosporine in the blood are used to assess if an appropriate drug concentration has been achieved; however, target blood drug concentrations have not been shown to reliably correlate with suppression of T‐cell function in the dog. In human transplant recipients, therapeutic drug monitoring has shifted to include pharmacodynamic‐based monitoring. Our laboratory has validated a RT‐qPCR assay to measure the pharmacodynamic effects of cyclosporine in the dog. In this study, activated T‐cell expression of IL‐2 and IFN‐γ was measured using RT‐qPCR daily for 7 consecutive days in 8 healthy Walker hounds receiving oral cyclosporine at a dosage of 10 mg/kg every 12 hr. Cytokine production was found to be markedly decreased within 24 hr after the initiation of cyclosporine and remained significantly decreased for the duration of the project. Based on these results, cyclosporine causes a rapid drop in T‐cell cytokine production that is sustained with continued dosing in healthy dogs. Although performed in healthy dogs, this study demonstrated a marked decrease in cytokine suppression within 24 hr of drug administration, suggesting that pharmacodynamic monitoring of cyclosporine's effects on T cells could be considered within several days of commencing therapy in dogs suffering from life‐threatening immune‐mediated disorders.  相似文献   

Prevention of post operative complications following surgical treatment of equine colic: Current evidence          下载免费PDF全文

S. E. Salem  C. J. Proudman  D. C. Archer 《Equine veterinary journal》2016,48(2):143-151

Changes in management of the surgical colic patient over the last 30 years have resulted in considerable improvement in post operative survival rates. However, post operative complications remain common and these impact negatively on horse welfare, probability of survival, return to previous use and the costs of treatment. Multiple studies have investigated risk factors for post operative complications following surgical management of colic and interventions that might be effective in reducing the likelihood of these occurring. The findings from these studies are frequently contradictory and the evidence for many interventions is lacking or inconclusive. This review discusses the current available evidence and identifies areas where further studies are necessary and factors that should be taken into consideration in study design.  相似文献   

Sequential bacterial sampling of the midline incision in horses undergoing exploratory laparotomy     

C. M. Isgren  S. E. Salem  N. B. Townsend  D. Timofte  T. W. Maddox  D. C. Archer 《Equine veterinary journal》2019,51(1):38-44

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On the distribution of tree growth stresses     

Professor R. R. Archer 《Wood Science and Technology》1976,10(4):293-309

Summary A plane strain pure bending model is used to predict stress states in a transversely isotropic cylinder due to asymmetric strain distributions continuously induced at the periphery. A general solution for the stress states related to each component of the strain distribution expanded in a Fourier series is given. An expression for the change of curvature due to each new growth increment is derived.This work was supported in part by NSF Grant ENG 74-02428.  相似文献   

On the distribution of tree growth stresses     

R. R. Archer 《Wood Science and Technology》1979,13(1):67-78

Summary Growth stress distributions in trees are derived using the hypothesis that longitudinal and circumferential growth strains are continuously induced at the periphery of the growing stem. A plane strain combined with pure torsion model is used to compute the internal stresses and strains due to forces and moments caused by the new growth increment. The twisting angle of the pure torsion model is caused by the shear stresses set up in the growth increment as the growth strains are induced along the grain axis and the coupling of axial and torsional effects due to the elastic constants for the inclined grain material. Detailed stress distributions are derived for a range of constant grain angle cases. The extreme sensitivity of the torsional shear distribution to small grain angles is noteworthy.This work was supported in part by NSF Grant ENG 74-02428  相似文献   

Surgical repair of a full-thickness ear pinna defect in a horse     

M. D. Cullen  A. Ehrle  S. C. Willson  J. M. Wilmink  D. C. Archer 《Equine Veterinary Education》2022,34(4):e169-e175

A 5-year-old gelding used for showing was presented for surgical repair of a full-thickness 15 mm diameter defect in the right pinna, which had occurred as a delayed complication following laser excision of a sarcoid. The defect had resulted in progressive deformity of the ear, and the horse was considered at risk of further injury if the defect became entrapped on a fixed object. Two artificial dermis meshes were inserted to encourage the formation of granulation tissue across the defect, and a commercially available skin expander was implanted adjacent to the site. Eighteen days later, a second surgery was performed to remove the skin expander and to mobilise a local rotational skin flap to close the defect. Both surgeries were performed under standing sedation and local anaesthesia. The site healed well, avoiding further potential trauma to the ear and deformity due to tissue contracture at the site, although some deformation of the lateral aspect of the cartilage remained.  相似文献