Myeloma-related disorders in cats commonly present as extramedullary neoplasms in contrast to myeloma in human patients: 24 cases with clinical follow-up     

Mellor PJ  Haugland S  Murphy S  Smith KC  Holloway A  Archer J  Powell RM  Polton GA  Tasker S  McCormick D  Tempest ME  McNeil PE  Scase TJ  Knott CD  Bonfanti U  Villiers EJ  Argyle DJ  Herrtage ME  Day MJ 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2006,20(6):1376-1383

BACKGROUND: Myeloma-related disorders (MRD) are rare neoplasms of plasma cells. Published case reports describe a diversity of clinical presentations with confusing terminology and diagnostic criteria as a consequence of the assumption that MRD in cats are analogous to those in dogs or humans. OBJECTIVE: The aim of the study was to describe clinical, clinicopathologic and imaging findings, response to treatment, survival and possible associations with other diseases or vaccination in a large case series. A priori hypotheses were that cats with MRD commonly present with extramedullary involvement and uncommonly have radiographic bone lesions, in contrast to human patients. ANIMALS: Twenty-four cats with MRD confirmed by cytology or histopathology and immunohistochemistry. METHOD: A multicenter retrospective study was performed. RESULTS: Two types of clinical presentation were observed. The first group (n = 17) had neoplasia involving abdominal organs, bone marrow, or both. All developed systemic clinical signs and paraproteinemia. Five of 7 cats that received chemotherapy improved clinically or had decreased serum globulin concentration (median survival, 12.3 months; range, 8.5-22 months). The second group comprised 7 cats with skin masses, 2 of which were paraproteinemic and developed rapidly worsening systemic signs. In cats without systemic signs, excision of the skin masses appeared to be associated with prolonged survival (up to 2.4 years). Cats with MRD commonly presented with extramedullary involvement (67%), versus humans with MRD (5%) (P < .001), and uncommonly presented with radiographic bone lesions (8%) versus humans with MRD (80%) (P < .001). CONCLUSIONS: Radiographic bone lesions are uncommon in cats with MRD and extramedullary presentation is common, relative to human myeloma.  相似文献   

What is your diagnosis? Intra‐abdominal mass aspirate from a spayed dog with abdominal pain     

Sarah Putwain  Joy Archer 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2009,38(2):253-256

Abstract: An 8‐year‐old, spayed female Labrador Retriever was presented for evaluation of unwillingness to exercise. On clinical examination abdominal pain was elicited, and a midabdominal mass was detected in survey radiographs. Ultrasound‐guided fine‐needle aspiration of the intra‐abdominal mass was done. The cytologic findings indicated chronic granulomatous inflammation with reactive fibroplasia, cholesterol crystals, and extracellular foreign material. The foreign material consisted of opaque, basophilic fragments of uniform width (5–10 μm) and variable length (30–180 μm) and was observed extracellularly and within macrophages. The material was birefringent under polarized light. Histologic examination of the excised mass confirmed the cytologic findings and a diagnosis of gossypiboma (textiloma) was made, consistent with retention of a surgical sponge. This case provides a unique example of the utility of fine‐needle aspiration for the diagnosis of gossypiboma.  相似文献   

Incidence and risk factors associated with exertional rhabdomyolysis syndrome in National Hunt racehorses in Great Britain     

Upjohn MM  Archer RM  Christley RM  McGowan CM 《The Veterinary record》2005,156(24):763-766

A telephone survey of 51 National Hunt racing yards with 1140 horses in training was made in April and May 2003 to establish the incidence of exertional rhabdomyolysis syndrome during the previous year. A case-control study was used to investigate the risk factors for the syndrome in eight yards selected on the basis that cases had been confirmed by the analysis of serum muscle enzymes. The overall incidence of syndrome was 6.1 cases per 100 horses per year, and 55 per cent of the yards reported at least one case. The risk factors identified were sex, the average length of the training gallop, and the type of horse (steeplechaser, bumper/unraced or hurdler). There were no significant associations with the horses' temperament, age or Timeform rating.  相似文献   

Solid substrate for production of Alternaria alternata conidia: a potential mycoherbicide for the control of Eichhornia crassipes (water hyacinth)     

RM Babu  A Sajeena  & K Seetharaman 《Weed Research》2004,44(4):298-304

Eichhornia crassipes (water hyacinth), a major aquatic weed in India, is one of the targets in a biological weed control research programme in India. A fungal pathogen, Alternaria alternata, is being evaluated as a biological control agent for this weed. The feasibility of solid substrate for the mass production of A. alternata has been examined. Conidia production and virulence of A. alternata were affected by temperature, light and incubation period. The highest number of conidia were produced on rice seed followed by wheat, sorghum, maize seeds and cornmeal at 20°C when exposed to near‐ultraviolet than on the other substrates, while the least conidia were observed on these substrates under light conditions. At 20°C, large numbers of virulent conidia were produced on rice seeds after 4 weeks of incubation under constant dark conditions. Henceforth, the use of rice seeds as a solid substrate for production of A. alternata could be a feasible method to produce conidia in a village co‐operative scenario in India.  相似文献   

High serum troponin I concentration as a marker of severe myocardial damage in a case of suspected exertional heatstroke in a dog     

Paul J. Mellor BVM&#x;S  CSAM  Richard J. Mellanby DSAM  Dipl ECVIM  Elizabeth A. Baines DVR  Dipl ECVDI  Elizabeth J. Villiers DRCPath  Joy Archer PhD  MRCPath  Dipl ECVP  Michael E. Herrtage DSAM  Dipl ECVIM  Dipl ECVDI 《Journal of Veterinary Cardiology》2006,8(1):55-62

A young, overweight dog presented with sudden onset lethargy and collapse following exercise in warm environmental conditions. Investigations revealed systolic hypotension, multiform ventricular premature complexes, irregular myocardial echogenicity with poor left ventricular systolic function and a markedly elevated troponin cTnI (180 ng/mL, reference range <0.3 ng/mL) consistent with severe myocyte damage. Infectious causes of myocarditis were ruled out on the basis of serological and polymerase chain reaction blood tests. Exercise-induced malignant hyperthermia was excluded from the history, an exercise tolerance test and genetic testing for the RYR1 V547A mutation. The diagnosis was myocardial damage secondary to suspected exertional heatstroke, from which the dog recovered uneventfully over a number of weeks and serum troponin normalised. This is the first case report in any species including man, documenting high troponin as a marker of severe myocardial damage following suspected heatstroke.  相似文献   

Effect of Insemination–Ovulation Interval and Addition of Seminal Plasma on Sow Fertility to Insemination of Cryopreserved Sperm     

M Abad  JC Garcia  DJ Sprecher  G Cassar  RM Friendship  MM Buhr  RN Kirkwood 《Reproduction in domestic animals》2007,42(4):418-422

In swine, the use of frozen-thawed (FT) sperm for artificial insemination (AI) is limited because of poor sow fertility, possibly associated with a post-thaw capacitation-like status resulting in fewer fully viable sperm. Sow fertility to AI with FT sperm may improve with deeper deposition of sperm within the female tract, insemination very close to ovulation, or reversal of cryocapacitation by seminal plasma (SP). We performed two experiments to examine these suggestions. In experiment 1, 122 multiparous Yorkshire sows received 600 IU equine chorionic gonadotrophin at weaning and 5 mg pLH 80 h later to control time of ovulation. The predicted time of ovulation (PTO) was 38 h after pLH injection. Thereafter, sows were assigned on the basis of parity to a single AI of FT sperm at 2 h before PTO, or at 12 h before PTO, or FT sperm supplemented with 10% SP at 12 h before PTO. Control sows received fresh semen at 12 h before PTO. All semen doses were adjusted to 3 x 10(9) live cells and deposited into the cervix. Experiment 2 employed 99 multiparous crossbred sows and repeated the treatments of experiment 1 except that all FT inseminations were intrauterine. In both experiments, farrowing rates were lower (p < 0.01) following FT inseminations with no effect of time of insemination or of supplemental SP. In experiment 1, litter size was smaller following FT insemination (p < 0.05), but no effect on litter size was evident in experiment 2. Supplemental SP had no effect on litter size in either experiment. The lack of effect of either SP or timing of FT insemination on sow fertility suggests that the non-lethal sperm cryoinjury affecting fertility involves more than just cryocapacitation.  相似文献   

Variations in potash levels in pastures grazed by horses: a preliminary communication     

M Archer 《Equine veterinary journal》1973,5(1):45-46

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Endosulfan residues on alfalfa hay exposed to drying by sunlight,ultraviolet light and air     

T. B. Archer 《Pest management science》1973,4(1):59-68

Endosulfan residues on alfalfa hay exposed to drying by sunlight, ultraviolet light and air under controlled conditions were investigated using g.l.c. and t.l.c. Maximum loss of total endosulfan and related residues calculated as endosulfan occurred approximately 7 days after application and exposure on Lot 1 (dark) and 5 days on Lot II (ultraviolet light) and 6 days on Lot III (sunlight). Maximum losses of residues on Lot I, Lot II and Lot HI were 48.3, 66.7 and 81.9%, respectively. No endosulfan lactone was detected in any of the samples exposed to the different light treatments. In all Lots the endosulfan sulphate percentage of the total residue increased but most dramatically in the dark drying experiment. The endosulfan a-hydroxy ether residues increased in Lot III (sunlight) up to day 7.  相似文献   

Buffalo river endangered     

Archer L 《Science (New York, N.Y.)》1967,158(3806):1266

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Further field studies on the fluorescent antibody test in the diagnosis of ovine abortion due to toxoplasmosis     

J F Archer  J K Beverley  W A Watson  D Hunter 《The Veterinary record》1971,88(7):178-180

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