排序方式： 共有44条查询结果，搜索用时 0 毫秒
31.
Hirashima A Eiraku T Shigeta Y Kuwano E Taniguchi E Eto M 《Pest management science》2002,58(11):1118-1125
Some octopamine (OA) agonists were found to suppress the calling behaviour and pheromone biosynthesis in vitro of the Indian meal moth, Plodia interpunctella (Hübner), a stored-product pest. Compounds were screened using a calling behaviour bioassay of female P interpunctella. Three active derivatives, with activity at the nanomolar level, were identified. In order of decreasing pheromonostatic activity these were: 2-(2-ethyl-6-methylanilino)oxazolidine > 2-(2,6-diethylanilino)thiazolidine > 2-(2,6-diethylanilino)oxazolidine. These compounds showed also in vitro inhibitory activities in de novo pheromone biosynthesis. Three-dimensional pharmacophore hypotheses were built from a set of 19 compounds. Among the ten common-featured models generated by the program Catalyst/HipHop, a hypothesis including a ring aromatic group (RA), a positive ionizable group (PI) and two hydrophobic aliphatic (HpA1) features was considered to be essential for inhibitory activity in the calling behaviour and pheromone biosynthesis in vitro. Active compounds mapped well onto all the RA, PI and HpA1 features of the hypothesis. Less-active compounds were shown not to achieve the energetically favourable conformation which was found in the active molecules in order to fit the 3-D common-feature pharmacophore models. The present studies demonstrate that inhibition of calling behaviour and PBAN-stimulated incorporation of radioactivity is by OA-agonistic activity. 相似文献
32.
Eiichi Kuwano Motohisa Shimizu Kenshi Shimazu Satoshi Nakazawa Koichi Suzuki 《Pest management science》1998,52(3):251-257
A new series of 5-(substituted phenoxy)pentyl 3-pyridyl ethers induced precocious metamorphosis in larvae of the silkworm, Bombyx mori. Both 2- and 4-pyridyl ethers were inactive, indicating that the 3-pyridine moiety was essential for the activity. Octyl, dodecyl and farnesyl 3-pyridyl ethers had no activity. Among the compounds tested so far, 5-(4-propylphenoxy)pentyl 3-pyridyl ether showed the highest activity. The activity fell off with increasing or decreasing length of the carbon chain between two oxygen atoms. Introduction of a methyl group at the 6 position of the pyridine ring completely eliminated the activity. Precocious metamorphosis induced by 3-pyridyl ethers was fully reversible by a simultaneous application of a small amount of tebufenozide, an ecdysteroid agonist, or methoprene, a JH agonist. © 1998 SCI. 相似文献
33.
Kasashima Y Kuwano A Katayama Y Taura Y Yoshihara T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2002,64(7):577-582
Six live horses with various stages of acute to chronic superficial digital flexor (SDF) tendinitis were examined using magnetic resonance imaging (MRI). In each case, MRI findings were compared to the corresponding ultrasonographic (USD) and histologic findings, to establish the usefulness of MRI. In the acute cases, lesions characterized by hemorrhage were well defined as high signal intensity on MRI and hypoechoic regions on USD. Chronic tendon fibrosis was slightly hyperechoic and difficult to distinguish from the normal tendon tissue around the original injury by using USD. In contrast, MRI visualized the chronic lesion as a low intensity signal, which could be distinguished from the black background of the normal SDF tendon tissue. This study clearly demonstrated MRI was the better imaging modality for the objective detection of chronic scar tissue in live horses. These findings, from living horses, suggest an advantage of MRI in the clinical application to diagnose tendinitis in cases where there is chronic scar tissue that is difficult to discern on USD. 相似文献
34.
Bla Darvas Huw H. Rees Nigel Hoggard Mahmoud H. Tag El-Din Eiichi Kuwano Ivn Blai Tibor Timr 《Pest management science》1992,36(2):135-142
The cytochrome P-450-dependent microsomal and mitochondrial ecdysone 20-monooxygenase systems convert ecdysone into 20-hydroxyecdysone. The microsomal fraction of fat bodies of zero h wandering stage fleshfly larvae (Neobellieria bullata; Diptera: Sarcophagidae) has a high ecdysone 20- monooxygenase activity. The effects of cytochrome P-450 inhibitors were investigated in vitro on microsomal ecdysone 20-monooxygenase. Metyrapone, fenarimol and certain imidazole derivatives (KK-42, KK-110, KK-135 and PIM) are strong inhibitors. The IC50 value of KK-110, which is the strongest inhibitor, is 2 × 10?7 M. A triazolyl and two cyclopropylamine derivatives have low activity. The activities of different NADPH-cytochrome c (P-450) reductase inhibitors were also assessed; diquat dibromide is a moderate inhibitor of microsomal ecdysone 20-monooxygenase, while paraquat dichloride has no activity. In-vivo experiments with cytochrome P-450 inducers and inhibitors gave the following results: (a) fenarimol, FI-121, precocene-2 caused “permanent” first-instar larvae; (b) barbital, phenobarbital and their sodium salts caused significant delay in larval development; (c) PIM, PTM, metyrapone, KK-42, KK-135, J-2710, RH 5849 and colchicine caused moulting disturbances; (d) J-2710, PIM, PTM, KK-42, KK-135, RH 5849 and colchicine caused lethal spiracle and mandible malformation; (e) KK-110, fenarimol, barbital and phenobarbital caused precocious pupariation. 相似文献
35.
Effects of biotin supplementation on serum biotin levels and physical properties of samples of solar horn of Holstein cows 
下载免费PDF全文
下载免费PDF全文 H. Higuchi T. Maeda M. Nakamura A. Kuwano K. Kawai M. Kasamatsu H. Nagahata 《Canadian journal of veterinary research》2004,68(2):93-97
Effects of dietary biotin supplementation on serum biotin levels and physical properties of sole horn of 40 Holstein cows were evaluated. The mean serum biotin level in biotin-supplemented cows after 10 mo of biotin supplementation (1163.2 +/- 76.2 pg/mL) was significantly higher (P = 0.007) than that in control cows (382.0 +/- 76.2 pg/mL). The sole horn of biotin-supplemented cows was significantly harder (P = 0.026) and had a significantly lower moisture content (P = 0.021) than that of control cows. No morphologic differences in horn tubules or intertubular horn were found between the biotin-supplemented and control cows. The total lipid content of sole horn was significantly higher (P = 0.030) in the biotin-supplemented cows than in the control cows. These results suggest that dietary biotin supplementation causes increases in serum biotin levels and changes in physical properties and fat content of sole horn. 相似文献
36.
37.
38.
Atsutoshi KUWANO Hidekazu NIWA Tohru HIGUCHI Hideya MITSUI Robert A. AGNE 《Journal of Equine Science》2012,23(3):41-46
A 3-year-old thoroughbred colt presented with canker on its left hind foot. Subsequent
development of cottage cheese-like horns and dermatitis disturbed healing, despite the use
of miscellaneous orthodox treatment approaches to the lesions. Histological examination
revealed exudative and suppurative dermatitis, and proliferatively suppurative epidermitis
infected with helically coiled treponemes. Total debridement under general anesthesia led
to a temporary improvement, but the ground surface regenerated abnormal epidermis similar
to that observed initially after surgery. Maggot debridement therapy (MDT) was attempted,
which removed all the abnormal tissue. After MDT, general farriery trimming helped to
correct the distorted ground surface, and the horse returned to constant training and
eventually raced. This case shows that MDT was successfully used for treatment of an
intractable and treponemes-infected canker. 相似文献
39.
Effects of supplemental β‐carotene on colostral immunoglobulin and plasma β‐carotene and immunoglobulin in Japanese Black cows 下载免费PDF全文
下载免费PDF全文 Shuntaro Ikeda Kenichi Yoshitani Atsutoshi Obata Yuji Sugie Yoshikazu Aoki Taisuke Yamaji Masahiko Fujita Yoshinobu Nakatsuji Shinichi Kume 《Animal Science Journal》2018,89(8):1102-1106
Data from 26 Japanese Black cows were collected to clarify the effects of supplemental β‐carotene on colostral immunoglobulin (Ig) and plasma β‐carotene and Ig in the cows. Cows were assigned to control or β‐carotene groups from 21 days before the expected calving date to 60 days after parturition. Supplemental β‐carotene was provided at 500 mg/day in the β‐carotene group. Supplemental β‐carotene drastically increased plasma β‐carotene concentrations in the cows from parturition to 60 days after parturition, and plasma β‐carotene concentrations in the control and β‐carotene groups at parturition were 202 and 452 μg/dl, respectively. Supplemental β‐carotene had no effects on plasma IgG1, IgA or IgM concentrations at parturition. Supplemental β‐carotene increased colostral IgG1 concentrations in the cows, but colostral β‐carotene, IgA and IgM concentrations were not affected by supplemental β‐carotene. These results indicate that supplemental β‐carotene is effective to enhance colostral IgG1 concentrations and plasma β‐carotene concentrations in Japanese Black cows. 相似文献
40.
Higuchi H Maeda T Kawai K Kuwano A Kasamatsu M Nagahata H 《Veterinary research communications》2003,27(5):407-413
Physiological changes in the concentrations of biotin in the serum and milk and in the physical properties of the claw horn were examined in Holstein cows. A lower concentration of biotin in the serum and a higher concentration of biotin in milk were found during early and late lactation and during the dry period, and a significant (p<0.05) inverse correlation was found between serum and milk biotin concentrations. A high moisture content and a low level of hardness of the claw horn were found during mid-lactation. Our results indicate that change in the serum biotin concentration probably results from the loss of biotin in the milk of cows during each stage of lactation and also confirm that the moisture content and hardness of the claw horn undergo physiological changes. 相似文献