Bioactive (3Z,5E)-11,20-epoxybriara-3,5-dien-7,18-olide diterpenoids from the South China Sea gorgonian Dichotella gemmacea     

Li C  La MP  Sun P  Kurtan T  Mandi A  Tang H  Liu BS  Yi YH  Li L  Zhang W 《Marine drugs》2011,9(8):1403-1418

Six new (3Z,5E)-11,20-epoxybriara-3,5-dien-7,18-olide diterpenoids, gemmacolides N-S (1-6), were isolated together with four known analogues, juncenolide D, and juncins R, S and U (7-10), from the South China Sea gorgonian Dichotella gemmacea. The structures of the new compounds were elucidated by the detailed analysis of spectroscopic data in combination with the comparison with reported data. The absolute configuration of 1 was determined by a TDDFT calculation of its solution ECD spectrum, affording the determination of absolute configuration of other analogues by simply comparing their ECD spectra with that of 1. The cytotoxic and antimicrobial activities of these compounds were evaluated. In preliminary in vitro bioassays, compounds 4, 5, 6, 8 and 9 showed cytotoxicity against A549 and MG63, while compounds 1, 2, 4, 7-10 showed antimicrobial activity against the fungus Septoria tritici and the bacterium Escherichia coli.  相似文献   

Geographical Spillovers and University Research: A Spatial EconometricPerspective   总被引：1，自引：0，他引：1  

Luc Anselin  Attila Varga  Zoltan Acs 《Growth and change》2000,31(4):501-515

Using data for U.S. metropolitan statistical areas, an earlier study of aggregate local geographic research spillovers generated by universities (Anselin et al.1997) was extended to a sectorally disaggregated level. These findings suggest the existence of significant sectoral variation with respect to local university effects on innovation. Apparent differences were found across sectors with respect to the “mix” of applied local knowledge inputs in general, and the extent to which university research plays a role in innovation in particular. The main conclusion is that local university spillovers seem to be specific to certain industries, such that at the two‐digit SIC level, no university spillover effects are at work in the Drugs and Chemicals (SIC28) and in the Machinery (SIC35) sectors. On the contrary, very strong and significant university research spillovers are evidenced in the Electronics (SIC36) and the Instruments (SIC38) industries. These spillovers extend beyond the boundary of the MSA within a 75‐mile range from the central city.  相似文献   

Experiments on the discovery of new drugs against cecal coccidiosis of chicks     

T Zsolnai 《Archiv fuer experimentelle veterinaermedizin》1970,24(5):1101-1112

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Solitary adenoma in the proventriculus of a budgerigar (Melopsittacus undulatus) diagnosed by immunochemistry - short communication     

János G  Marosán M  Kozma A  Mándoki M 《Acta veterinaria Hungarica》2011,59(4):439-444

The authors describe a solitary adenoma in a 5.5-year-old female Budgerigar (Melopsittacus undulatus). The tumour was partially blocking the lumen of the proventriculus and filled it almost completely. Decreased passage of food towards the gizzard and the intestines developed in the bird as result of the obstruction, which periodically hindered the passage, leading to slow emaciation. An epithelial tumour composed of irregular glandular acini was diagnosed by histological examination. Immunohistochemical reaction with pancytokeratin showed a positive cytoplasmic reaction both in the neoplastic and the normal glandular structures.  相似文献   

Precision Weed Detection using Terrestrial Laser Scanning Techniques     

Péter Riczu  Attila Nagy  Éva Lehoczky  János Tamás 《Communications in Soil Science and Plant Analysis》2015,46(4):309-316

Weeds compete with cultivated plants for nutrients and water in agricultural fields and orchards. Site-specific precision plant protection requires optimal plant-specific pesticide combinations and quantities. The first step in precision weed control is to map and detect weeds. Active and passive remote-sensing tools are available for weed detection. This article presents a study of precision weed detection using three-dimensional terrestrial laser scanning in an apple (Malus domestica) orchard. The laser scanner was able to identify two monocotyledonous (Digitaria sanguinalis, Echinochloa crus-galli) and two dicotyledonous (Galinsoga parviflora, Portulaca oleracea) weed species. In addition to weed identification, weed coverage was also determined using three algorithms. The results indicate that laser scanning has the potential for fast, accurate weed detection and could support the development of a plant-specific, selective, precision weed-control system that reduces water and pesticide use in orchards.  相似文献   

Modelling the Potential Effects of the Hungarian Red Mud Disaster on Soil Properties     

Attila Anton  Márk Rékási  Nikolett Uzinger  Gábor Széplábi  András Makó 《Water, air, and soil pollution》2012,223(8):5175-5188

In this experiment, the effects of the Hungarian red mud disaster were studied in a soil column experiment focusing on element solubility. The effect of flooding with the highly alkaline red mud suspension and the effect of the percolation of precipitation water through the 10 cm thick red mud layer were modelled separately. Both scenarios affected the soil pH up to a depth of 80 cm. An increase in the total element concentration was only observed for Na and Mo, probably due to the leaching of red mud particles measuring 0.05?C0.02 and <0.002 mm in the column. At the same time, the water-soluble concentrations of the potentially toxic elements As, Co, Cr, Cu, Ni, Pb, and Zn rose, at least in the top soil layer, but the concentration values remained below the limit values laid down by quality standards. Over a longer period of time, the main environmental risk raised by the disaster is the secondary salinization of the area.  相似文献   

Neuronal Modulators from the Coral-Associated Fungi Aspergillus candidus     

Gao-Yang Peng  Tibor Kurtn  Attila Mndi  Jing He  Zheng-Yu Cao  Hua Tang  Shui-Chun Mao  Wen Zhang 《Marine drugs》2021,19(5)

Three new p-terphenyl derivatives, named 4″-O-methyl-prenylterphenyllin B (1) and phenylcandilide A and B (17 and 18), and three new indole-diterpene alkaloids, asperindoles E–G (22-24), were isolated together with eighteen known analogues from the fungi Aspergillus candidus associated with the South China Sea gorgonian Junceela fragillis. The structures and absolute configurations of the new compounds were elucidated on the basis of spectroscopic analysis, and DFT/NMR and TDDFT/ECD calculations. In a primary cultured cortical neuronal network, the compounds 6, 9, 14, 17, 18 and 24 modulated spontaneous Ca²⁺ oscillations and 4-aminopyridine hyperexcited neuronal activity. A preliminary structure–activity relationship was discussed.  相似文献   

Detection and analysis of porcine circovirus type 1 in Hungarian wild boars: short communication     

Cságola A  Kiss I  Tuboly T 《Acta veterinaria Hungarica》2008,56(1):139-144

Porcine circovirus type 1 (PCV1) is considered to be a non-pathogenic virus detected in cell cultures, vaccines or products used for cell culture preparations, all of them of porcine origin. Serological evidence and genetic studies suggested that PCV1 was widespread in domestic pigs. The presence of PCV1 in wild boars in Germany was also described using serological methods. This paper reports the first detection of PCV1 in Hungarian wild boars. Samples were collected at slaughterhouses and processed for polymerase chain reactions. The complete genome of PCV1 detected in the samples was determined and compared with the available PCV1 sequences of the GenBank database. The genomes formed two distinct clusters with minimum differences, where the Hungarian wild boar PCV1 (WB-H8) grouped together with genomes originating from domestic swine from China and Australia and with a genome detected in a porcine pepsin product.  相似文献   

Small-scale agricultural landscapes promote spider and ground beetle densities by offering suitable overwintering sites     

Róbert Gallé  Péter Császár  Tímea Makra  Nikolett Gallé-Szpisjak  Zsuzsanna Ladányi  Attila Torma  Kapilkumar Ingle  Péter Szilassi 《Landscape Ecology》2018,33(8):1435-1446

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Identification of a new self-incompatibility allele (S₃₁) in a Hungarian almond cultivar and its reliable detection     

Júlia Halsz  gota Fodor  Attila Heged&#x;s  Andrzej Pedryc 《Scientia Horticulturae》2008,116(4):448-451

Self-incompatibility of almond [Prunus dulcis (Mill.) D.A. Webb] is controlled by the S-locus with 30 described allelic variants. In this study, PCR amplification, cloning and DNA sequence analysis revealed a new S-RNase allele in a Hungarian cultivar, ‘Tétényi bőtermő’. This new allele was labelled as S₃₁. Since S₃₁ is characterized by almost identical intron sizes as S₉, consensus PCR was not successful in discrimination of the alleles, even if fluorescently labelled fragments were sized on an automated sequencer. Therefore, an allele-specific forward primer (PdS31-F) was designed to anneal selectively within the second intron of the S₃₁-RNase gene and used in combination with the EM-PC3consRD consensus primer. This allowed for the successful discrimination of S₃₁ from S₉. The PdS31-F primer and allele-specific PCR in general might be useful in the identification of different alleles with matching intron sizes that might occur during screening for S-alleles in a more diverse population, e.g. local cultivars from Central Europe to Asia.  相似文献