Artibeus jamaicensis: delayed embryonic development in a neotropical bat   总被引：1，自引：0，他引：1  

T H Fleming 《Science (New York, N.Y.)》1971,171(969):402-404

In Panama the phyllostomid bat Artibeus jamaicensis is seasonally polyestrous, and young are born in March or April and July or August. Blastocysts conceived after the second birth implant in the uterus but are dormant from September to mid-November, when normal development again resumes.  相似文献   

Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease     

Outeiro TF  Kontopoulos E  Altmann SM  Kufareva I  Strathearn KE  Amore AM  Volk CB  Maxwell MM  Rochet JC  McLean PJ  Young AB  Abagyan R  Feany MB  Hyman BT  Kazantsev AG 《Science (New York, N.Y.)》2007,317(5837):516-519

The sirtuins are members of the histone deacetylase family of proteins that participate in a variety of cellular functions and play a role in aging. We identified a potent inhibitor of sirtuin 2 (SIRT2) and found that inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson's disease. Genetic inhibition of SIRT2 via small interfering RNA similarly rescued alpha-synuclein toxicity. Furthermore, the inhibitors protected against dopaminergic cell death both in vitro and in a Drosophila model of Parkinson's disease. The results suggest a link between neurodegeneration and aging.  相似文献   

RECENT PROGRESS OF SCIENCE     

Fleming S 《Science (New York, N.Y.)》1881,2(35):76-78

  相似文献   

TWELFTH ANNUAL MEETING OF THE AMERICAN GEOPHYSICAL UNION     

Fleming JA 《Science (New York, N.Y.)》1931,73(1904):705-707

  相似文献   

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein     

Willingham S  Outeiro TF  DeVit MJ  Lindquist SL  Muchowski PJ 《Science (New York, N.Y.)》2003,302(5651):1769-1772

Genome-wide screens were performed in yeast to identify genes that enhance the toxicity of a mutant huntingtin fragment or of alpha-synuclein. Of 4850 haploid mutants containing deletions of nonessential genes, 52 were identified that were sensitive to a mutant huntingtin fragment, 86 that were sensitive to alpha-synuclein, and only one mutant that was sensitive to both. Genes that enhanced toxicity of the mutant huntingtin fragment clustered in the functionally related cellular processes of response to stress, protein folding, and ubiquitin-dependent protein catabolism, whereas genes that modified alpha-synuclein toxicity clustered in the processes of lipid metabolism and vesicle-mediated transport. Genes with human orthologs were overrepresented in our screens, suggesting that we may have discovered conserved and nonoverlapping sets of cell-autonomous genes and pathways that are relevant to Huntington's disease and Parkinson's disease.  相似文献   

THE SIXTEENTH ANNUAL MEETING OF THE AMERICAN GEOPHYSICAL UNION     

Fleming JA 《Science (New York, N.Y.)》1935,82(2129):373-374

  相似文献   

THE SEVENTH ANNUAL WASHINGTON CONFERENCE OF THEORETICAL PHYSICS,MAY 22-24, 1941     

Teller E  Gamow G  Fleming JA 《Science (New York, N.Y.)》1941,94(2430):92-94

  相似文献   

Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop.   总被引：72，自引：0，他引：72  

T Miki  T P Fleming  D P Bottaro  J S Rubin  D Ron  S A Aaronson 《Science (New York, N.Y.)》1991,251(4989):72-75

An expression cloning strategy was devised to isolate the keratinocyte growth factor (KGF) receptor complementary DNA. NIH/3T3 fibroblasts, which secrete this epithelial cell-specific mitogen, were transfected with a keratinocyte expression complementary DNA library. Among several transformed foci identified, one demonstrated the acquisition of specific high-affinity KGF binding sites. The pattern of binding competition by related fibroblast growth factors (FGFs) indicated that this receptor had high affinity for acidic FGF as well as KGF. The rescued 4.2-kilobase complementary DNA was shown to encode a predicted membrane-spanning tyrosine kinase related to but distinct from the basic FGF receptor. This expression cloning approach may be generally applicable to the isolation of genes that constitute limiting steps in mitogenic signaling pathways.  相似文献   

WILLIAM JOHN PETERS     

Fleming JA 《Science (New York, N.Y.)》1942,96(2484):127-128

  相似文献   

Kinetic isotope effects for the reactions of muonic helium and muonium with H2     

Fleming DG  Arseneau DJ  Sukhorukov O  Brewer JH  Mielke SL  Schatz GC  Garrett BC  Peterson KA  Truhlar DG 《Science (New York, N.Y.)》2011,331(6016):448-450

The neutral muonic helium atom may be regarded as the heaviest isotope of the hydrogen atom, with a mass of ~4.1 atomic mass units ((4.1)H), because the negative muon almost perfectly screens one proton charge. We report the reaction rate of (4.1)H with (1)H(2) to produce (4.1)H(1)H + (1)H at 295 to 500 kelvin. The experimental rate constants are compared with the predictions of accurate quantum-mechanical dynamics calculations carried out on an accurate Born-Huang potential energy surface and with previously measured rate constants of (0.11)H (where (0.11)H is shorthand for muonium). Kinetic isotope effects can be compared for the unprecedentedly large mass ratio of 36. The agreement with accurate quantum dynamics is quantitative at 500 kelvin, and variational transition-state theory is used to interpret the extremely low (large inverse) kinetic isotope effects in the 10(-4) to 10(-2) range.  相似文献