A comparison of epidural buprenorphine with epidural morphine for postoperative analgesia following stifle surgery in dogs   总被引：2，自引：1，他引：2  

Lesley J Smith  DVM  Diplomate ACVA    Jeff Kwang-An Yu  BS 《Veterinary anaesthesia and analgesia》2001,28(2):87-96

Objective To compare the efficacy of epidural buprenorphine with epidural morphine for post‐operative pain relief in dogs undergoing cranial cruciate ligament rupture repair. Study design A randomized, double blind clinical trial. Animals Twenty client‐owned dogs with cranial cruciate ligament rupture. Methods Dogs were randomly assigned to receive either epidural buprenorphine (4 µg kg^?1) or epidural morphine (0.1 mg kg^?1) in a total volume of 0.2 mL kg^?1. Epidural injections were performed immediately after induction of anesthesia. End‐tidal halothane and CO₂ were recorded every 15 minutes from the time of epidural administration of drug to extubation. A numerical rating pain score system was used by a blinded observer to evaluate analgesia beginning at extubation and continuing at specific intervals for 24 hours after surgery. Heart rate, respiratory rate, and blood pressure were recorded noninvasively at the same times. If pain score indicated moderate discomfort, rescue morphine at 1.0 mg kg^?1 was administered intramuscularly. Results There were no significant differences between groups with respect to pain score, heart rate, respiratory rate, indirect blood pressure, end‐tidal halothane or end‐tidal CO₂ at any time point. Fifty percent of dogs in the buprenorphine group and 50% of dogs in the morphine group required rescue analgesic medication. Time of systemic rescue morphine administration did not differ significantly between the two groups. There were no clinically observable side‐effects from epidural administration of either drug in any of the dogs of this study. Conclusions Epidural buprenorphine is as effective as epidural morphine for the relief of postoperative hindlimb orthopedic pain in dogs. Clinical relevance Buprenorphine appears to be an effective opioid for epidural use in healthy dogs. Buprenorphine may offer certain advantages over morphine for epidural use, such as lower abuse potential and, in some clinics, reduced cost and less wastage of drug.  相似文献   

Outcome after Placement of an Artificial Urethral Sphincter in 27 Dogs     

Lauren Reeves BS  Christopher Adin DVM  Mary McLoughlin DVM  MS  Kathleen Ham DVM  Dennis Chew DVM 《Veterinary surgery : VS》2013,42(1):12-18

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Effects of a Cross‐linked Hyaluronic Acid Based Gel on the Healing of Open Wounds in Dogs     

Heather S. Hadley DVM  Bryden J. Stanley BVMS  MVetSc  Diplomate ACVS  Michele C. Fritz BS  LVT  Joe G. Hauptman DVM  MS  Diplomate ACVS  Barbara A. Steficek DVM  PhD  Diplomate ACVP 《Veterinary surgery : VS》2013,42(2):161-169

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The Effects of Feed Form on Consumption Time and Glucose and Insulin Response to a Concentrate Meal in Equine     

Mary E. Gordon PhD  Michael L. Jerina BS  Randel H. Raub PhD  Karen E. Davison PhD  J. Kathleen Young PhD 《Journal of Equine Veterinary Science》2008,28(5):289-294

This study tested the hypothesis that feeding an identically formulated, low sugar and starch concentrate in three forms (5-mm extruded [E], 4-mm pellet [P], and 19-mm oval [O]) would affect consumption rate and glucose or insulin responses, or both. Horses received 1.8 kg treatment feed in a randomized, crossover design, with samples taken every 30 minutes for 6 hours for blood glucose and insulin response. Pearson's correlation compared consumption time, insulin and glucose peak, and time to peak insulin and glucose. The pellet (P) elicited a lower (P = .01) glucose concentration at 2.5 hours than O. The pellet also elicited a lower (P = .03) insulin concentration at 5.5 hours than E and O. There were no differences (P > .05) in area under the curve (AUC) insulin, peak insulin, and time to peak insulin for the three treatments. Average insulin concentration was lower (P = .01) for P versus O. There were no differences (P > .05) in average insulin between P and E, nor between O and E. There were no differences (P > .05) in AUC and peak glucose concentration. Time to peak glucose was longer (P = .04) for P versus E. Average glucose concentration was lower (P = .02) for P versus O. Consumption time was longer (P = .03) for O versus P. There was a positive correlation between consumption time and time to peak insulin (r = 0.46, P = .029). Further research on feeding practices, feed forms, and consumption times that affect glycemic response is necessary.  相似文献   

The Effect of Sedation on Gastric Emptying of a Liquid Marker in Ponies     

Thomas J. Doherty  MVB  MSc  Diplomate ACVA    Frank M. Andrews  DVM  MS  Diplomate ACVIM    Melanie K. Provenza  BS    Donita L. Frazier  DVM  PhD  Diplomate ABVT 《Veterinary surgery : VS》1999,28(5):375-379

OBJECTIVE: The effect of sedation on gastric emptying was evaluated in six ponies by monitoring serum concentrations of acetaminophen (AP) after intragastric administration. EXPERIMENTAL DESIGN: Prospective randomized experimental study. ANIMALS: Six adult ponies, 135 to 275 kg. METHODS: Fifteen minutes after the intravenous administration of xylazine (1 mg/kg), butorphanol (0.05 mg/kg), acepromazine (0.05 mg/kg) or saline, ponies were given AP (20 mg/kg in 350 mL water) by stomach tube. Blood for AP analysis was collected at baseline and 15, 30, 45, 75, 90, 105, and 120 minutes after AP administration. The time (Tmax) to reach peak serum concentration (Cmax), and the area under the AP serum concentration versus time curve (AUC) were determined for each treatment group. RESULTS: Tmax was 31 mins in the control group, and this increased significantly (P<.05) after sedation. Cmax decreased (P<.05) after xylazine administration, and AUC decreased (P<.05) after acepromazine. CONCLUSIONS: This study indicated that sedation has a significant effect on the gastric emptying rate of a liquid in ponies.  相似文献   

Evaluation of pacing site in dogs with naturally occurring complete heart block     

Amara H. Estrada  Herbert W. Maisenbacher III  VMD  Robert Prošek  DVM  MS  Jesse Schold  PhD  Melanie Powell  BS  James M. VanGilder  BS 《Journal of Veterinary Cardiology》2009,11(2):79-88

Objective

To compare left ventricular synchronization and systolic performance with transvenous pacing of the right ventricular apex (RVA), left ventricular free wall (LVF) or simultaneous pacing of the RVA and LVF (BiV).

Animals, materials and methods

Seven canine patients with complete heart block. Prospective study evaluating effect of pacing site. Twenty four hours following implantation of transvenous BiV pacing systems, electrocardiograms and echocardiograms were assessed during pacing from the: (1) Right Atrial Appendage/RVA (RAA/RVA), (2) RAA/LVF, and (3) RAA/BiV.

Results

QRS duration was significantly shorter with BiV pacing versus LVF pacing (p < 0.001), or RVA pacing (p < 0.001). Echocardiographic indices of systolic performance fractional shortening (FS), ejection fraction (EF), cardiac output (CO) were significantly higher with BiV pacing than with pacing from the RVA (P = 0.023, 0.006, and 0.002 respectively). Cardiac output, measured by the biplane Simpson's method, was higher with LVF versus RVA pacing (P = 0.036). There was no difference in FS or EF when comparing LVF to RVA pacing. Tissue Doppler measurements of synchronization and systolic performance did not show any difference between pacing mode, but a significantly increased number of segments were seen to contract following aortic valve closure during LVF pacing (P = 0.0268) and RVA pacing (P = 0.0197) as compared to BiV pacing.

Conclusions

Findings suggest that BiV pacing improves cardiac output and systolic performance versus RVA pacing. This improvement however, is not reflected in tissue Doppler indices of synchronization and systolic performance.  相似文献   

Localization of Oestrogen Receptors in the Epididymis During Sexual Maturation of the Domestic Cat     

J Schön  S Neumann  DE Wildt  BS Pukazhenthi  K Jewgenow 《Reproduction in domestic animals》2009,44(S2):294-301

Oestrogens are involved in regulation of spermatogenesis and sperm maturation and are essential for male fertility. To study the role of oestrogens on epididymal function in the domestic cat, we analyzed the localization patterns of oestrogen receptors (ERs) within the epididymis of juvenile, pubertal and adults using immunohistochemistry. Cat epididymal tissues obtained during routine castrations were fixed in chilled Bouin's solution and processed for immunohistochemistry with ER-specific antibodies. For a certain receptor type, ER localization was influenced by donor age. In the juvenile epididymis, ERα was localized in the nuclei of epithelial cells of efferent ducts and undifferentiated epithelium of the ductus epididymis. During puberty, ERα localization in the undifferentiated epithelium of the epididymis shifted from the nuclei to the cytoplasm and plasma membrane. Oestrogen receptor-α level was highest in the pubertal and adult epididymis, especially within the cytoplasm and in plasma membranes of caput epithelial cells. This finding was suggestive of a role in fluid reabsorption within the efferent ducts and the epididymis. In corpus and cauda regions, ERα was less abundant, suggesting a minor role for oestrogens in sperm storage areas. Interestingly, localization of ERβ was neither influenced by age nor location within the epididymis and was ubiquitous throughout. Results demonstrate that oestrogen actions within the epididymis may be predominantly mediated through ERα during sexual maturation in the domestic cat.  相似文献   

Follicular Morphology, Oocyte Diameter and Localisation of Fibroblast Growth Factors in the Domestic Dog Ovary     

N Songsasen  A Fickes  BS Pukazhenthi  DE Wildt 《Reproduction in domestic animals》2009,44(S2):65-70

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Pelvic limb kinematics in the dog with and without a stifle orthosis          下载免费PDF全文

Bryan T. Torres DVM  PhD  DACVS‐SA  Yang‐Chieh Fu PhD  Gabriella S. Sandberg BS  Steven C. Budsberg DVM  MS  DACVS 《Veterinary surgery : VS》2017,46(5):642-652

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Laparoscopic evaluation of the small intestine in the standing horse: Technique and effects*          下载免费PDF全文

Andrew R. E. Jones BVetMed MRCVS  Claude A. Ragle DVM  DACVS  DABVP  Dusty Anderson BS  Coryelle Scott BS 《Veterinary surgery : VS》2017,46(6):812-820

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