Spatio-temporal dynamics of visceral leishmaniasis in Brazil: A nonlinear regression analysis     

Fábio Raphael Pascoti Bruhn  Guilherme Loureiro Werneck  David Soeiro Barbosa  Daniel Cardoso Portela Câmara  Taynãna César Simões  Lia Puppim Buzanovsky  Anna Gabryela Sousa Duarte  Saulo Nascimento de Melo  Diogo Tavares Cardoso  Lucas Edel Donato  Ana Nilce Silveira Maia-Elkhoury  Vinícius Silva Belo 《Zoonoses and public health》2024,71(2):144-156

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Na+/K+-ATPase Activation by cAMP in the Midgut of Lutzomyia longipalpis (Lutz & Neiva, 1912; Diptera: Psychodidae)     

Denise Barguil Nepomuceno  Grasielle Caldas Dvila Pessoa  Ricardo Nascimento Araújo  Leonardo Barbosa Koerich  Maurício Roberto Viana Sant&#x;Anna  Marcos Horcio Pereira  Nelder Figueiredo Gontijo 《Journal of insect science (Online)》2022,22(2)

Lutzomyia longipalpis (Lutz & Neiva, 1912) females have been intensively studied regarding the regulation of midgut pH. The mechanisms involved in pH regulation are complex, and some aspects remain to be clarified. Here, we investigated the role of the Na⁺/K⁺-ATPase pump as an electrochemical potential generator and its modulation by the second messenger cAMP in the midgut of female L. longipalpis. Our results suggest that not only may Na⁺/K⁺-ATPase be the main generator of an electrochemical potential across membranes in the midgut of female L. longipalpis, but also its activity is positively regulated by cAMP. cAMP-mediated Na⁺/K⁺-ATPase pump activity might be necessary to maintain the transport of the nutrients produced during blood digestion.  相似文献   

Salmonella infections in pigs fattened with pellets and unpelleted meal     

W Edel  P A Guinée  M van Schothorst  E H Kampelmacher 《Zentralblatt für Veterin?rmedizin. Reihe B. Journal of veterinary medicine. Series B》1967,14(5):393-401

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Effects of tiletamine/zolazepam-romifidine-atropine in ocelots (Leopardus pardalis)     

Selmi AL  Figueiredo JP  Mendes GM  Lins BT 《Veterinary anaesthesia and analgesia》2004,31(3):222-226

OBJECTIVES: To evaluate the effects of a combination of tiletamine-zolazepam-romifidine-atropine in ocelots. DESIGN: Prospective experimental trial. ANIMALS: Eight captive adult ocelots (three females and five males). METHODS: Calculated doses of tiletamine-zolazepam (3.75 mg kg(-1)), romifidine (50 microg kg(-1)) and atropine (0.04 mg kg(-1)) were administered intramuscularly. After immobilization, animals were weighed and the real doses determined. Heart rate, respiratory frequency, noninvasive systolic, diastolic, and mean arterial pressure, arterial oxygen hemoglobin saturation, and rectal temperature were measured. Data were analyzed by means of anova for repeated measures, followed by the Tukey test to compare values over time. RESULTS: Doses administered were 3.4 +/- 0.6 mg kg(-1) of tiletamine-zolazepam, 0.04 +/- 7.0 mg kg(-1) of romifidine, and 0.03 +/- 0.007 mg kg(-1) of atropine. The mean time to recumbency and duration of immobilization were 7.0 +/- 4.5 and 109.2 +/- 27.9 minutes, respectively. The median times to standing and walking were 52.3 [0-90] and 2.3 [0-69.3] minutes, respectively. A decrease in heart rate was observed 45 minutes following drug administration. Arterial blood pressure was maintained during the study. CONCLUSIONS AND CLINICAL RELEVANCE: This protocol produced good immobilization in ocelots with minimal changes over time in cardiovascular parameters.  相似文献   

Comparison of medetomidine-ketamine and dexmedetomidine-ketamine anesthesia in golden-headed lion tamarins          下载免费PDF全文

Selmi AL  Mendes GM  Figueiredo JP  Barbudo-Selmi GR  Lins BT 《The Canadian veterinary journal. La revue veterinaire canadienne》2004,45(6):481-485

The cardiovascular, respiratory, and anesthetic effects of medetomidine-ketamine (20 microg/kg bodyweight [BW] and 10 mg/kg BW) (MK group) or dexmedetomidine-ketamine (10 microg/kg BW and 10 mg/kg BW) (DK group) were studied in golden-headed lion tamarins. Heart rate decreased after administration of both combinations; this reduction was statistically greater in the DK group than in the MK group after 15 and 45 minutes. Systolic arterial pressure decreased in a similar way in both groups, except at 15 minutes, when systolic arterial pressure was significantly lower in the DK group. Diastolic arterial pressure, mean arterial pressure, respiratory rate, and rectal temperature were progressively reduced in all groups. Sedation time was significantly shorter and anesthesia time was significantly longer in the DK group compared with MK group. Anesthetic quality and analgesia scores were significantly greater at 5 and 15 minutes in the DK group compared with the MK group. The administration of dexmedetomidine-ketamine is as safe and effective as the administration of medetomidine-ketamine in tamarins.  相似文献   

Evaluation of an epidemic of sporotrichosis in cats: 347 cases (1998-2001)     

Schubach TM  Schubach A  Okamoto T  Barros MB  Figueiredo FB  Cuzzi T  Fialho-Monteiro PC  Reis RS  Perez MA  Wanke B 《Journal of the American Veterinary Medical Association》2004,224(10):1623-1629

OBJECTIVE: To evaluate characteristics of a large epidemic of sporotrichosis in cats. DESIGN: Retrospective study. ANIMALS: 347 cats with naturally acquired infection with Sporothrix schenckii. PROCEDURE: Medical records were reviewed for data regarding clinical, mycologic, histopathologic, and routine hematologic and serum biochemical findings; assays for FIV-specific antibodies and FeLV antigen; antifungal treatment; and follow-up. RESULTS: Lesions varied from small papules to extensive zones of necrosis.Ten cats had no skin lesions, 114 had skin lesions at a single site, 86 had skin lesions in 2 sites, and 137 had skin lesions in 3 or more sites. Respiratory tract signs were observed in 154 cats and were the most frequent extracutaneous sign. Anemia, leukocytosis with neutrophilia, hypoalbuminemia, and hyperglobulinemia were the main blood abnormalities. Antibodies against FIV were detected in 28 cats, FeLV antigen was detected in 2 cats, and both were detected in 1 cat among 142 cats tested. During the study, 118 cats were lost to follow-up and 124 died. Of 266 cats that were treated, 68 were cured. Complete healing of the lesions was observed regardless of the presence of extracutaneous signs, general condition, treatment schedule, or coinfection with FIV. CONCLUSIONS AND CLINICAL RELEVANCE: Feline sporotrichosis was evident in subclinical to severe forms; however, cats can respond well to regular and prolonged antifungal treatment.  相似文献   

Xenotransplantation of goat ovary as an alternative to analyse follicles after vitrification     

Nathalie Jiatsa Donfack  Kele Amaral Alves  Benner Geraldo Alves  Rebeca Magalhes Pedrosa Rocha  Jamily Bezerra Bruno  Carlos H. Lobo  Marcelo Bertolini  Regiane Rodrigues dos Santos  Marilia de Oliveira Taumaturgo  Ramon da Silva Raposo  Jos Ricardo de Figueiredo  Johan Smitz  Ana Paula Ribeiro Rodrigues 《Reproduction in domestic animals》2019,54(2):216-224

The aim of this study was to evaluate the caprine preantral follicles enclosed on vitrified/warmed ovarian cortex grafted to nude BALB/mice during 1 month. The ovarian cortex from goats was fragmented (3 × 3 × 0.5 mm) and divided into four groups: fresh control, vitrified control, fresh transplant and vitrified transplant. Follicular morphology, development and density, fibrosis as well as apoptosis, and tissue revascularization were evaluated. It was also observed a significant decrease in morphologically normal preantral (primordial, transition, primary and secondary) follicles in both vitrified control and vitrified transplant treatments when compared with both fresh control and fresh transplant. However, fresh control and fresh transplant exhibited a similar percentage of developing follicles. Additionally, Vitrified control showed a significant increase in developing follicles in comparison with both fresh control and fresh transplant. Follicular density significantly decreased in all treatments in comparison with fresh control. We observed high fibrosis in both fresh transplant and vitrified transplant. The mRNA expression of caspase 3 was lower in both fresh transplant and vitrified transplant in comparison with vitrified control. In conclusion, xenotransplantation is an excellent strategy to maintain normal preantral follicle morphology after vitrification/warming of goat ovarian tissue. Yet, in order to ensure the survival and development of these follicles, it is essential to improve the revascularization of the graft.  相似文献   

Reduced-rank estimation of genetic parameters for egg production traits and cluster analyses with predicted breeding values     

Luara Afonso de Freitas  Rodrigo Pelicioni Savegnago  Natalia Vinhal Grupioni  Salvador Boccaletti Ramos  Nedenia Bonvino Stafuzza  Elsio Antônio Pereira de Figueiredo 《Acta Agriculturae Scandinavica, Section A - Animal Sciences》2018,68(2):81-86

The aims of this study were to compare the suitability of the multi-trait (MUT) model to estimate genetic parameters with that of 13 reduced-rank principal component models (PC1 to PC13), and then to explore the additive genetic patterns of the breeding values obtained from these using clustering analyses of egg production traits. A total of 1,212 records were used to estimate genetic parameters using the MUT and PC models. The PC4 model was the best representation of the data since it had a lower AIC value and was more parsimonious than the MUT model. The estimated heritability of the age at the first egg (AFE) trait from this model was 0.28?±?0.06, and the estimated genetic correlation between AFE and total egg production (TP) was ?0.52?±?0.23. Potentially animals from cluster 2 are more likely to be in the selected group to help improve the egg production.  相似文献   

Considering dominance in reduced single‐step genomic evaluations          下载免费PDF全文

J. Ertl  C. Edel  E.C.G. Pimentel  R. Emmerling  K.‐U. Götz 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2018,135(3):151-158

Single‐step models including dominance can be an enormous computational task and can even be prohibitive for practical application. In this study, we try to answer the question whether a reduced single‐step model is able to estimate breeding values of bulls and breeding values, dominance deviations and total genetic values of cows with acceptable quality. Genetic values and phenotypes were simulated (500 repetitions) for a small Fleckvieh pedigree consisting of 371 bulls (180 thereof genotyped) and 553 cows (40 thereof genotyped). This pedigree was virtually extended for 2,407 non‐genotyped daughters. Genetic values were estimated with the single‐step model and with different reduced single‐step models. Including more relatives of genotyped cows in the reduced single‐step model resulted in a better agreement of results with the single‐step model. Accuracies of genetic values were largest with single‐step and smallest with reduced single‐step when only the cows genotyped were modelled. The results indicate that a reduced single‐step model is suitable to estimate breeding values of bulls and breeding values, dominance deviations and total genetic values of cows with acceptable quality.  相似文献   

Genotyping of groups of cows to improve genomic breeding values of new traits          下载免费PDF全文

Laura Plieschke  Christian Edel  Eduardo C. G. Pimentel  Reiner Emmerling  Jörn Bennewitz  Kay‐Uwe Götz 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2018,135(4):286-292

Genotyping females and including them into the reference set for genomic predictions in dairy cattle is considered to provide gains in reliabilities of estimated breeding values for selection candidates. This should especially be true for low heritability traits. By the use of simulation, we extended a genomic reference set for an existing trait by including a fixed number of genotyped first‐crop daughters for one or two generations of reference sires. Moreover, we calculated results for the effects of a similar strategy in a situation where for a new trait the recording of phenotypes has recently started. For this case, we compared the effect of two different genotyping strategies: first, to phenotype cows but to genotype their sires only, and second, to collect phenotypes and genotypes on the same cows. We studied the effects on validation reliabilities and unbiasedness of predicted values for selection candidates. We found that by extending the reference set with genotyped daughters it is possible to increase the validation reliability of genomic breeding values. In the case of a new trait, it is always better to collect and use genotypes and phenotypes on the same animals instead of using only sire genotypes. We found that the benefits that can be achieved are sensitive to the sampling strategy used when selecting females for genotyping.  相似文献