Letter to the editor     

W.M.M. Baron 《Biological conservation》1976,9(3):235

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Humeral air sac cystadenocarcinoma in a rainbow lorikeet (Trichoglossus moluccanus)     

HR Baron  TSY Foo  DN Phalen 《Australian veterinary journal》2020,98(4):168-171

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Intracranial extension of retrobulbar blastomycosis (Blastomyces dermatitidis) in a dog     

Baron ML  Hecht S  Westermeyer HD  Mankin JM  Novak JM  Donnell RL 《Veterinary ophthalmology》2011,14(2):137-141

Blastomycosis (Blastomyces dermatitidis) is a fungal disease that is endemic in the southern United States. This case report illustrates the clinical, MRI and histopathologic findings in a dog with invasion of a retrobulbar blastomycotic lesion into the calvarium. A 5‐year‐old intact female Weimaraner was referred for a 2‐month history of change in behavior and recent onset of visual deficits. Magnetic resonance imaging (MRI) examination revealed a large (5.8 × 2.0 × 2.5 cm) mass extending from the left orbit through a circular defect in the left cranioventral aspect of the calvarium caudally to the level of the pituitary fossa and interthalamic adhesion. The mass was heterogeneously iso‐ to hypointense on T2‐W images, slightly hypointense on T1‐W images, did not attenuate on fluid attenuated inversion recovery (FLAIR) images, and did not show evidence of susceptibility artifact on T2*‐W gradient recalled echo (GRE) images. Vasogenic edema and associated mass effect were noted. The mass showed strong homogeneous contrast enhancement with well‐defined margins and had thickening of the adjacent meninges (dural tail sign). Based on MRI findings a malignant neoplastic process was considered most likely and the patient was placed on oral prednisone to decrease peri‐tumoral inflammation. The dog initially improved but was euthanized 3 weeks later for worsening clinical signs. Histopathologic assessment of the mass revealed marked pyogranulomatous optic neuritis with intralesional fungal yeasts consistent with blastomycosis (Blastomyces dermatitidis). To our knowledge this is the first report of invasion of a retrobulbar blastomycotic lesion into the calvarium in a dog.  相似文献   

IEG's: Some Evaluations     

Siekevitz P  Doermann AH  Gallant JA  McCarthy BJ  Morris DR  Nester E  Rutter WJ  Jukes TH  Green DE  Gergely J  Dameshek W  Baron S 《Science (New York, N.Y.)》1966,154(3747):332-336

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Interferon: lack of detectable uptake by cells   总被引：6，自引：0，他引：6  

C E Buckler  S Baron  H B Levy 《Science (New York, N.Y.)》1966,152(718):80-82

No interferon, or at most a small fraction of that applied, is taken up by cells during the period of induction of antiviral activity. The lack of detectable adsorption was not influenced either by the concentration of interferon or the volume. The results were similar in both chicken and mouse systems.  相似文献   

Anchorless prion protein results in infectious amyloid disease without clinical scrapie     

Chesebro B  Trifilo M  Race R  Meade-White K  Teng C  LaCasse R  Raymond L  Favara C  Baron G  Priola S  Caughey B  Masliah E  Oldstone M 《Science (New York, N.Y.)》2005,308(5727):1435-1439

In prion and Alzheimer's diseases, the roles played by amyloid versus nonamyloid deposits in brain damage remain unresolved. In scrapie-infected transgenic mice expressing prion protein (PrP) lacking the glycosylphosphatidylinositol (GPI) membrane anchor, abnormal protease-resistant PrPres was deposited as amyloid plaques, rather than the usual nonamyloid form of PrPres. Although PrPres amyloid plaques induced brain damage reminiscent of Alzheimer's disease, clinical manifestations were minimal. In contrast, combined expression of anchorless and wild-type PrP produced accelerated clinical scrapie. Thus, the PrP GPI anchor may play a role in the pathogenesis of prion diseases.  相似文献   

Oral Salmonella typhimurium vaccine expressing circumsporozoite protein protects against malaria   总被引：28，自引：0，他引：28  

J C Sadoff  W R Ballou  L S Baron  W R Majarian  R N Brey  W T Hockmeyer  J F Young  S J Cryz  J Ou  G H Lowell 《Science (New York, N.Y.)》1988,240(4850):336-338

Immunization with radiation-attenuated malaria sporozoites induces potent cellular immune responses, but the target antigens are unknown and have not previously been elicited by subunit vaccines prepared from the circumsporozoite (CS) protein. A method is described here for inducing protective cell-mediated immunity to sporozoites by immunization with attenuated Salmonella typhimurium transformed with the Plasmodium berghei CS gene. These transformants constitutively express CS antigens and, when used to immunize mice orally, colonize the liver, induce antigen-specific cell-mediated immunity, and protect mice against sporozoite challenge in the absence of antisporozoite antibodies. These data indicate that the CS protein contains T cell epitopes capable of inducing protective cell-mediated immunity, and emphasize the importance of proper antigen presentation in generating this response. Analogous, orally administered vaccines against human malaria might be feasible.  相似文献   

Herpetic keratoconjunctivitis: therapy with synthetic double-stranded RNA   总被引：21，自引：0，他引：21  

J H Park  S Baron 《Science (New York, N.Y.)》1968,162(855):811-813

A study was undertaken in rabbits to determine how late in the course of keratoconjunctivitis caused by herpes simplex recovery could be effected by an inducer of interferon. Interferon was induced by means of synthetic double-stranded RNA copolymer formed with polynosinic acid: polycytidilic acid RNA. Therapy promotes recovery from severe and fully established keratoconjunctivitis for which treatment was begun as late as 3 days after virus inoculation. No drug toxicity was observed in the therapeutic dose range. These findings further support the proposed role of the interferon mechanism in the natural recovery of already established viral infection. They also suggest the usefulness of interferon inducers in viral infections of man.  相似文献   

Diversity of human alpha beta T cell receptors     

Arstila TP  Casrouge A  Baron V  Even J  Kanellopoulos J  Kourilsky P 《Science (New York, N.Y.)》2000,288(5469):1135

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Interferon     

Baron S  Finter NB  Galasso GJ  Glasgow LA  Levy HB  Younger JS 《Science (New York, N.Y.)》1973,180(4087):779-784

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