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OBJECTIVE: To assess the kinetic behavior of 3 preparations of alpha-tocopherol (vitamin E) after oral administration to heifers. ANIMALS: 8 postpubertal Friesian heifers. PROCEDURE: A single oral bolus of 5,000 U of alpha-tocopherol in oil or encapsulated in liposomes or cyclodextrin was administered to each cow, using a 4 X 4 design with 8 days between treatments. Blood samples for kinetic analyses were obtained at various times for 168 hours after treatment. RESULTS: Mean (+/- SEM) maximal plasma concentrations of alpha-tocopherol were 4.86 +/- 0.49 microg/ml, 5.03 +/- 0.39 microg/ml, and 5.08 +/- 0.56 microg/ml after administration of oil, liposomal, and cyclodextrin preparations, respectively. Plasma concentrations peaked 21 to 34 hours after administration. The disappearance rate constant (Kd) was less after administration of alpha-tocopherol encapsulated in liposomes, compared with the other 2 preparations. Area under the concentration versus time curve was greater after administration of either encapsulated form of alpha-tocopherol, compared with alpha-tocopherol in oil, but these differences were not significant. CONCLUSIONS AND CLINICAL RELEVANCE: The lower Kd determined for alpha-tocopherol encapsulated in liposomes suggests that this formulation may result in longer persistance of the vitamin in plasma than the other 2 preparations. Dietary supplementation with alpha-tocopherol encapsulated in liposomes may enhance plasma availability of this vitamin in cattle and could be useful during periods of increased vitamin E requirements, such as parturition and early stages of life.  相似文献   
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Maintaining the health of dogs and cats by feeding wholesome nutritional diets is becoming an important component of responsible pet ownership. Pet owners now seek a long and healthy life for their pet and look to nutrition, as well as to veterinary medicine, to provide such support. Quality of life, measured in terms of reduced incidence of diseases and the ability to maintain an active life, would appear to be able to be enhanced by appropriate nutrition and nutraceutical supplementation. As a consequence numerous improvements in companion animal nutrition have resulted in development of a wide array of foods that provide complete and balanced nutrition. As a result emphasis also has to be placed on product safety and quality parameters, in connection with traceability. The origin of products, including product characteristics and properties, processing conditions and further handling throughout the period chain, is becoming ever increasingly an issue for collective chain management.

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