Hormonal response to dobutamine cardiac stress testing in a conscious canine model of early left ventricular dysfunction induced by chronic rate overload     

K. Mc Entee DVM  PhD  dipl ECVIM-CA  C. Clercx DVM  PhD  Dipl ECVIM-CA  T. Flandre DVM  E. Jonville DVM  C. Pynnaert DVM  R. Van Beneden MS  JM Ketelslegers MD  PhD  C. Michaux DVM  Phd  M. Balligand DVM  PhD  dipl ECVS-CA  N. Miserque DVM  M. Henroteaux DVM 《Journal of Veterinary Cardiology》2000,2(2):7

The aims of this study were to investigate (1) hormonal activation before and during dobutamine cardiac stress testing (DST) in a canine model of early left ventricular dysfunction (ELVD) induced by rapid right ventricular pacing (RRVP) and (2) the relationship between this hormonal profile and carnitine concentrations.Before the pacing period, the 6 dogs were assigned to 2 groups according their baseline total plasma carnitine concentration. A DST was performed on each dog before activation of the pacemaker and every 3 to 4 days during development of 3 progressive stages of ELVD (stages 1, 2 and 3). Plasma atrial natriuretic factor (ANF), angiotensin II (ANG II) and endothelin-1 (ET-1) levels were measured at the start and at the end of each DST. Effects of ELVD, DST and plasma carnitine concentration on these measurements were tested.The RRVP induced a significant increase of ANF and ANG II and a non significant trend toward increase of ET-1 in all dogs.Before the pacing period, ANF remained constant during the DST in dogs with normal total plasma carnitine concentration, while it significantly decreased in dogs with low total plasma carnitine concentration. Dobutamine stress testing induced a significant decrease in ANF in all dogs in ELVD. Dobutamine infusion induced a significant increase in ANG II in all dogs before as well as during the pacing period while ET-1 was unchanged.These results suggest that investigation of the hormonal profile before and after a dobutamine challenge might provide important diagnostic information in dogs with asymptomatic or mildly symptomatic cardiac dysfunction of different origins.  相似文献   

Hydrogen bonding part 46: a review of the correlation and prediction of transport properties by an lfer method: physicochemical properties,brain penetration and skin permeability     

Michael H Abraham  Harpreet S Chadha  Filomena Martins  Robert C Mitchell  Michael W Bradbury  Julie A Gratton 《Pest management science》1999,55(1):78-88

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The effects of induced parturition in dairy cows on the incidence of mortality in calves from commercial herds in south-western Victoria     

JM MORTON  KL BUTLER† 《Australian veterinary journal》1995,72(1):5-7

SUMMARY The effects of induced parturition on calf mortality rates were studied in 24 winter-calving, pasture-fed, dairy herds in south-western Victoria. Parturition was induced when most cows were between 27 and 35 weeks of pregnancy. Control groups were selected from cows in the same herds in which calving was not induced. The incidence of mortality within 7 days of birth was much higher among calves from cows in induced groups relative to those in control groups (estimated median herd mortality incidence 72% and 7%, respectively). The incidence of calf mortality was high among groups induced at all stages of pregnancy that were investigated. However, differences in calf mortality incidence, relative to controls, were increased among groups induced at earlier stages of pregnancy.  相似文献   

The presence of Giardia and other zoonotic parasites of urban dogs in Hobart, Tasmania   总被引：1，自引：0，他引：1  

TC MILSTEIN  JM GOLDSMID 《Australian veterinary journal》1995,72(4):154-155

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Spongiform encephalopathy in an imported cheetah (Acinonyx jubatus)   总被引：1，自引：0，他引：1  

RL PEET  JM CURRAN 《Australian veterinary journal》1992,69(7):171-171

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Vetch toxicosis in cattle grazing Vicia villosa ssp dasycarpa and V benghalensis     

PAW HARPER  RW COOK†  PA GILL†  GC FRASER†  LM BADCOE‡  JM POWER§ 《Australian veterinary journal》1993,70(4):140-144

SUMMARY The epidemiological, clinical and pathological features of a disease syndrome in adult cattle grazing woolly-pod vetch (Vicia villosa ssp dasycarpa) or popany vetch (V benghalensis) are reported. Outbreaks of toxlcosis occurred between midwinter and midsummer in 3 dairy and 6 beef herds on the north coast of New South Wales, between 1982 and 1992. Friesian, Angus, Murray Grey, Guernsey and Hereford breeds were affected. Mean morbidity and case fatality rates in affected herds were 7% (65 of 889) and 69%, respectively. Signs of pruritic dermatitis, illthrift and death were associated with an eosinophilic granulomatous inflammation of many organs, particularly involving the renal cortex, dermis, myocardium, adrenal glands, lymph nodes and hepatic portal triads.  相似文献   

Influence of Body Condition and Restricted Suckling on Post-partum Reproductive Performance of Zebu Cows (Bos indicus) in the Humid Tropics     

JM Bolaños  M. Forsberg  H. Kindahl  H. Rodríguez-Martínez 《Reproduction in domestic animals》1996,31(2):363-367

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Histopathological Alterations of lamina propria and Sertoli Cells in Severe Testicular Hypoplasia in Polled Goats     

JM Flores  MA Sanchez  A. Rodriguez  E Mateos Rex 《Reproduction in domestic animals》1996,31(2):349-352

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Hyperlipaemia in a donkey     

JM TARRANT  TM CAMPBELL  BW PARRY 《Australian veterinary journal》1998,76(7):466-469

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Seroprevalence of equine herpesvirus 1 in Thoroughbred foals before and after weaning     

JR GILKERSON  DN LOVE  HE DRUMMER  MJ STUDDERT  JM WHALLEY 《Australian veterinary journal》1998,76(10):677-682

Objective To investigate the seroprevalence of equine herpesvirus 1 in foals around weaning and after weaning on two large Thoroughbred farms using a type-specific enzyme-linked immunosorbent assay to determine exposure to infection.
Design A longitudinal population study in groups of Thoroughbred weanling foals.
Study population Two hundred weanling Thoroughbred foals from a population of about 380 foals were enrolled on two adjacent stud farms in the Hunter Valley of New South Wales. Foals on both farms were weaned from February to May 1995 into randomly selected groups of 10 to 15 foals. Farms were selected because of their willingness to cooperate in the survey and because their detailed records of foals and their movements. They were representative of well-managed large Thoroughbred stud farms in New South Wales. Both studs had upper respiratory tract disease among weanling foals around weaning each year although the sero-prevalence of viral respiratory disease on either farm was not known before the study.
Procedure Serum was collected from foals within each group at fortnightly intervals from 9th February until 1st June 1995, and at a single follow-up period in August 1995. Each sample was tested in triplicate using an antibody-detection ELISA which is type-specific for EHV-1 and EHV-4 antibodies.
Results and conclusions There was serological evidence of EHV-1 infection both before and after weaning. The prevalence of EHV-1 antibody in the sample population increased during the study and individual cases of EHV-1 infection were identified. The increase was caused both by the seroconversion of foals within the groups and by the recruitment into the study of foals with pre-existing EHV-1 antibody. Evidence of EHV-1 infection in Thoroughbred foals after weaning has not been reported previously in Australia and this has implications for vaccination regimens.  相似文献