A survey of the incidence of infections with salmonellae in broilers and broiler breeders in Scotland     

D D Brown  R H Duff  J E Wilson  J G Ross 《The British veterinary journal》1973,129(5):493-500

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Theileria parva: comparative infectivity of a ground tick stabilate and a classical 10-tick challenge   总被引：2，自引：0，他引：2  

M P Cunningham  C G Brown  M J Burridge  A D Irvin  R E Purnell  D E Radley 《Research in veterinary science》1973,15(2):263-265

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Chloramphenicol sodium succinate in the horse: serum, synovial, peritoneal, and urine concentrations after single-dose intravenous administration     

M P Brown  R H Kelly  R R Gronwall  S M Stover 《American journal of veterinary research》1984,45(3):578-580

Six healthy adult mares were given a single IV dose (25 mg/kg of body weight) of chloramphenicol sodium succinate. Chloramphenicol concentrations in serum, synovial fluid, peritoneal fluid, and urine were measured serially over a 48-hour period. The highest measured serum chloramphenicol concentration was 6.21 micrograms/ml at 0.5 hour. Chloramphenicol was detected in synovial and peritoneal fluids, with mean peak concentrations of 3.89 micrograms/ml and 3.50 micrograms/ml, respectively, at 0.5 hour. Serum and synovial concentrations declined rapidly and were not measurable at 3 hours. Chloramphenicol could not be detected in peritoneal fluid at 6 hours. The serum half-life was 0.43 hour and the apparent volume of distribution was 2.83 L/kg. Urine concentrations of chloramphenicol peaked at 0.5 hour at 106.72 micrograms/ml and also declined rapidly. The drug could not be detected in the urine at 36 hours.  相似文献   

Assessment of myocardial function in the horse. 1. Theoretical and technical considerations.     

C M Brown  J R Holmes 《Equine veterinary journal》1979,11(4):244-247

The paper discusses the various parameters which are currently used in attempts to assess the contractile efficiency of the myocardium in various species. These procedures depend upon accurate recording of intracavity pressure. The response of a catheter-mounted microtransducer compared with a fluid-filled catheter manometer system is illustrated to show the advantage of the former in providing a true representation of pressure changes.  相似文献   

The effect of systemic fungicides,applied as seed treatments or early foliar sprays,on speckled leaf blotch of wheat, Mycosphaerella graminicola (Fuckel) Schroeter     

J.S Brown 《Crop Protection》1984,3(1):59-65

Control of speckled leaf blotch (Mycosphaerella graminicola) of wheat (Triticum aestivum) with systemic fungicides used as seed treatments or foliar sprays was studied. Seed treatment with either imazalil (1·125 g/kg seed), nuarimol (0·2 g/kg), thiabendazole (1·5 and 0·75 g/kg), triadimenol (0·3 and 0·2 g/kg) or Shell WL 47675 (0·415 g/kg) reduced the number of infected plants by 28–62% when assessments were made 11 weeks after sowing. Thiabendazole (1·5 and 0·75 g/kg) and triadimefon (0·3 and 0·2 g/kg) slowed the development of speckled leaf blotch for c. 15 weeks after sowing. A single foliar spray of triadimefon (125 g/ha) slowed the development of the disease for c. 10 weeks, but a single spray of benomyl controlled it for the whole season. There was no additional benefit from combining a seed treatment of triadimefon (0·225 g/kg) with the foliar spray.  相似文献   

Lack of peripheral sympathetic control of uterine blood flow during acute heat stress     

D E Brown  P C Harrison 《Journal of animal science》1984,59(1):182-188

Peripheral alpha- and beta-adrenergic control of uterine blood flow (UBF) during acute heat stress of the gravid ewe was investigated. An electromagnetic blood flow probe was surgically implanted around the left miduterine artery and catheters inserted in the left carotid artery and right jugular vein in ewes between d 120 and 130 of gestation. Four or more days postsurgery, ewes were fitted with instruments to measure rectal temperature (Tr), heart rate (HR), respiratory rate (RR), blood pressure (BP) and UBF. One-half hour after instrument calibration, a 15-min thermoneutral control period was initiated with carotid artery blood samples taken at 5-min intervals for pH and PCO2 determinations. Ewes were then subjected to a heat challenge that reached 40 C at 2 h. All physiological data were recorded every 5 min as 1-min mean values. In seven experiments on five ewes, an alpha-adrenergic blocking drug, phenoxybenzamine (PB) was infused at 1 mg/min for 15 min subsequent to maximum depression of UBF. A beta-adrenergic blocking drug, propranolol (PR) was infused at .35 mg/min for 15 min in eight experiments on five ewes. Analysis of variance comparisons were made between the control period and heat stress infusion periods within the PB and PR experiments. Further comparisons were made between the start and 5, 10 or 15 min of PB or PR infusion in order to test drug effects during an acute heat stress. Rectal temperature HR, RR and arterial pH were higher (P less than .05) at the start of PR and PB infusions than during the thermoneutral control period.(ABSTRACT TRUNCATED AT 250 WORDS)  相似文献   

Immunohistochemical characteristics of canine aortic and carotid body tumours     

Brown PJ  Rema A  Gartner F 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2003,50(3):140-144

In an immunohistochemical study of 25 canine chemodectomas, 17 tumours were stained with antisera to neurone specific enolase and the same number were stained for synaptophysin; a single tumour was stained for S100. Staining for Ki-67 occurred in 18 cases; the Ki-67-labelling index and the intensity of immunostaining was increased in more pleomorphic and malignant tumours, as assessed on histological grounds. Immunohistochemistry did not aid in recognition of less well-differentiated tumours.  相似文献   

Salivary gland basal cell adenocarcinoma: a report of cases in a cat and two dogs     

Sozmen M  Brown PJ  Eveson JW 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2003,50(8):399-401

Basal cell adenocarcinoma of the salivary gland is described in a cat and two dogs; tumour tissue was characterized by cords and islands of epithelial cells with a distinct basal layer. The tumours were stained by various immunohistochemical methods. In addition to positive staining with cytokeratin 14 and pancytokeratin (CKs 5, 6, 8, 17 and 19), there was also staining with Jack bean agglutinin A (ConA) and soya bean agglutinin (SBA); this occurs in many other types of salivary gland tumours and is a feature of normal salivary gland acinar cells. In one dog there was also staining with SBA. This is the first report of this tumour in domestic animals; the immunohistochemical characteristics did not distinguish it from other salivary gland tumours.  相似文献   

Vulnerabilities in agriculture     

Brown C 《Journal of veterinary medical education》2003,30(2):112-114

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Safety of a modified-live combination vaccine against respiratory and reproductive diseases in pregnant cows     

Ellsworth MA  Brown MJ  Fergen BJ  Ficken MD  Tucker CM  Bierman P  TerHune TN 《Veterinary therapeutics : research in applied veterinary medicine》2003,4(2):120-127

A combination vaccine (Bovi-Shield FP4 + L5, Pfizer Animal Health) containing modified-live virus (MLV) components against bovine herpesvirus-1 (BHV-1), bovine viral diarrhea virus BVDV), parainfluenza virus-3 (PI3), bovine respiratory syncytial virus (BRSV), and inactivated cultures of Leptospira canicola, grippotyphosa, hardjo, icterohaemorrhagiae, and pomona was evaluated for safety in pregnant beef and dairy animals. Heifers vaccinated prebreeding with the minimum immunizing dose (lowest antigen level initiating immunizing effects) of the vaccine's MLV BHV-1 or BVDV components and during pregnancy (approximately 200 days of gestation) with vaccine containing 10x doses of the same BHV-1 and BVDV components delivered live, healthy calves that were determined to be serologically negative (titer less than 1:2) for neutralizing antibodies to BHV-1 and BVDV prior to nursing. Additionally, in three field safety studies, previously vaccinated cows and heifers that received a field dose (vaccine containing antigen levels required for commercial sale of the MLV combination vaccine during either the first, second, or third trimester of pregnancy had abortion rates similar to those of pregnant cows and heifers vaccinated during the same stage of pregnancy with sterile water diluent.  相似文献