Clinical,metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome b5 reductase deficiency in cats     

Jared A. Jaffey  N. Scott Reading  Urs Giger  Osheiza Abdulmalik  Ruben M. Buckley  Sophie Johnstone  Leslie A. Lyons   《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2019,33(6):2725-2731

Two non‐pedigreed male castrated cats had persistent cyanosis over a 3‐year observation period. Clinical cardiopulmonary evaluations did not reveal abnormalities, but the blood remained dark after exposure to air. Erythrocytic methemoglobin concentrations were high (~40% of hemoglobin) and cytochrome b₅ reductase (CYB5R) activities in erythrocytes were low (≤15% of control). One cat remained intolerant of exertion, and the other cat developed anemia and died due to an unidentified comorbidity. Whole‐genome sequencing revealed a homozygous c.625G>A missense variant (B4:137967506) and a c.232‐1G>C splice acceptor variant (B4:137970815) in CYB5R3, respectively, which were absent in 193 unaffected additional cats. The p.Gly209Ser missense variant likely disrupts a nicotinamide adenine dinucleotide (NADH)‐binding domain, while the splicing error occurs at the acceptor site for exon 4, which likely affects downstream translation of the protein. The 2 novel CYB5R3 variants were associated with methemoglobinemia using clinical, biochemical, genomics, and in silico protein studies. The variant prevalence is unknown in the cat population.  相似文献   

DESPOT, a process-based tree growth model that allocates carbon to maximize carbon gain     

Buckley TN  Roberts DW 《Tree physiology》2006,26(2):129-144

We present a new model of tree growth, DESPOT (Deducing Emergent Structure and Physiology Of Trees), in which carbon (C) allocation is adjusted in each time step to maximize whole-tree net C gain in the next time step. Carbon gain, respiration and the acquisition and transport of substitutable photosynthetic resources (nitrogen, water and light) are modeled on a process basis. The current form of DESPOT simulates a uniform, monospecific, self-thinning stand. This paper describes DESPOT and its general behavior in comparison to published data, and presents an evaluation of the sensitivity of its qualitative predictions by Monte Carlo parameter sensitivity analysis. DESPOT predicts determinate height growth and steady stand-level net primary productivity (NPP), but slow declines in aboveground NPP and leaf area index. Monte Carlo analysis, wherein the model was run repeatedly with randomly different parameter sets, revealed that many parameter sets do not lead to sustainable NPP. Of those that do lead to sustainable growth, the ratios at maturity of net to gross primary productivity and of leaf area to sapwood area are highly conserved.  相似文献   

Tree ring correlation between prehistoric landslides and abrupt tectonic events in Seattle, washington     

Jacoby GC  Williams PL  Buckley BM 《Science (New York, N.Y.)》1992,258(5088):1621-1623

Radiocarbon ages of submerged trees on landslide deposits in Lake Washington, Seattle, indicate that the most recent slides in three separate areas may have occurred simultaneously about 1000 years ago. Tree ring crossdating shows that seven bark-bearing trees from one of these recent slides and a tree 23 kilometers to the northwest in a probable tsunami deposit on the shore of Puget Sound died in the same season of the same year. The close coincidence among the most recent lake landslides, a probable tsunami, abrupt subsidence, and other possible seismic events gives evidence for a strong prehistoric earthquake in the Seattle region.  相似文献   

Zona pellucida dissolution enzymes of the rabbit sperm head   总被引：1，自引：0，他引：1  

R Stambaugh  J Buckley 《Science (New York, N.Y.)》1968,161(841):585-586

Enzymes which dissolve the zona pellucida have been extracted from the rabbit sperm head and characterized as having the enzymic properties of hyaluronidase and trypsin. Their combined actions produce a rapid and complete dissolution of the zona pellucida, but the vitellus and its membrane are unaffected by prolonged exposure to this enzyme complex. Inhibition of the proteolytic component with lima bean or soybean inhibitors of trypsin prevents dissolution of the zona pellucida by the extract.  相似文献   

Large-scale tree planting initiatives as an opportunity to derive carbon and biodiversity co-benefits: a case study from Aotearoa New Zealand     

Suryaningrum  Febyana  Jarvis  Rebecca M.  Buckley  Hannah L.  Hall  David  Case  Bradley S. 《New Forests》2022,53(4):589-602

New Forests - Planting trees is widely regarded as an important part of climate change mitigation and adaptation efforts. As a result, large-scale tree planting projects have been initiated around...  相似文献   

The pace of shifting climate in marine and terrestrial ecosystems   总被引：2，自引：0，他引：2  

Burrows MT  Schoeman DS  Buckley LB  Moore P  Poloczanska ES  Brander KM  Brown C  Bruno JF  Duarte CM  Halpern BS  Holding J  Kappel CV  Kiessling W  O'Connor MI  Pandolfi JM  Parmesan C  Schwing FB  Sydeman WJ  Richardson AJ 《Science (New York, N.Y.)》2011,334(6056):652-655

Climate change challenges organisms to adapt or move to track changes in environments in space and time. We used two measures of thermal shifts from analyses of global temperatures over the past 50 years to describe the pace of climate change that species should track: the velocity of climate change (geographic shifts of isotherms over time) and the shift in seasonal timing of temperatures. Both measures are higher in the ocean than on land at some latitudes, despite slower ocean warming. These indices give a complex mosaic of predicted range shifts and phenology changes that deviate from simple poleward migration and earlier springs or later falls. They also emphasize potential conservation concerns, because areas of high marine biodiversity often have greater velocities of climate change and seasonal shifts.  相似文献   

Integrating community gardens into public parks: An innovative approach for providing ecosystem services in urban areas     

Isaac Middle  Peta Dzidic  Amma Buckley  Dawn Bennett  Marian Tye  Roy Jones 《Urban Forestry & Urban Greening》2014,13(4):638-645

When planned coherently, urban green spaces have the potential to provide cities with a range of unique ecosystem services that support ecosystem and human health. This paper draws on existing green space planning literature to argue that the integration of community gardens into standardised and previously under-utilised public park landscapes represents an innovative approach to providing ecosystem services. Particular focus is given to the challenges facing green space planning in Perth, Western Australia. At an individual level, community gardens provide a venue for an alternative and more accessible form of physical activity – gardening – and a restorative park environment that is a more attractive destination for neighbourhood walking. At the community level, gardens can facilitate bridging interactions between different social groups, whilst providing opportunities for local residents to participate actively in green space planning processes. Perhaps most importantly, community gardens can provide unique opportunities for environmental education that lead to enhanced local ecological outcomes. The paper concludes with a brief overview of the main challenges likely to be faced with this integration, and some strategies that may allow them to be overcome. It is hoped this paper will provide a background for future case studies, and a catalyst for increasing integration between formal green space planning and community garden development.  相似文献   

How riding may affect welfare: What the equine veterinarian needs to know     

P. McGreevy  A. McLean  P. Buckley  F. McConaghy  C. McLean 《Equine Veterinary Education》2011,23(10):531-539

Veterinarians generally focus on keeping the performance horse in work but they need to be mindful of ways in which the work itself may jeopardise the animal's welfare and health. Elements of a horse's work may expose it to the risk of injury but insults to wellbeing, which are far more common and far more sustained, although less overt, also deserve consideration. A good example is the way in which chronic physiological stress responses arising from inhumane training techniques may compromise immunity and tissue repair. This article explores the physiological and musculoskeletal insults that can result from ridden work, alongside the gear and training paradigms that can compromise welfare. It also considers issues relating to the use of pharmaceuticals in the ridden horse. With stress reduction as a primary focus, it emerges that veterinarians are uniquely placed to comment on the somatic effects of psychological stressors, including the social and ethological challenges resulting from the work required of the so‐called elite equine athlete. Whether the profession will step up to meet this significant challenge is also discussed.  相似文献   

Significant features of the epidemiology of equine influenza in New South Wales, Australia, 2007     

Moloney B  Sergeant ES  Taragel C  Buckley P 《Australian veterinary journal》2011,89(Z1):56-63

Equine influenza (EI) was first diagnosed in the Australian horse population on 24 August 2007 at Centennial Park Equestrian Centre (CPEC) in Sydney, New South Wales (NSW), Australia. By then, the virus had already spread to many properties in NSW and southern Queensland. The outbreak in NSW affected approximately 6000 premises populated by approximately 47,000 horses. Analyses undertaken by the epidemiology section, a distinct unit within the planning section of the State Disease Control Headquarters, included the attack risk on affected properties, the level of under-reporting of affected properties and a risk assessment of the movement of horses out of the Special Restricted Area. We describe the epidemiological features and the lessons learned from the outbreak in NSW.  相似文献   

Cardiopulmonary effects of a new inspiratory impedance threshold device in acute hemorrhagic shock in dogs     

Alessio Vigani DVM  PhD  Andre C. Shih DVM  DACVA  Gareth J. Buckley MA  VetMB  DACVECC  MRCVS  Leonel Londoño DVM  Carsten Bandt DVM  DACVECC 《Journal of Veterinary Emergency and Critical Care》2011,21(6):618-624

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