Midazolam enhances the analgesic properties of dexmedetomidine in the rat     

Boehm CA  Carney EL  Tallarida RJ  Wilson RP 《Veterinary anaesthesia and analgesia》2010,37(6):550-556

ObjectiveTo investigate the analgesic properties of different dose combinations of midazolam and dexmedetomidine administered intraperitoneally (IP) in the rat.Study designProspective experimental trial.AnimalsSeventy adult male Sprague Dawley rats weighing 250-300 g.MethodsDexmedetomidine (D) 0.03, 0.06, 0.09, 0.12, 0.15, 0.18, 0.21 mg kg^?1 and midazolam (M) 5, 10, 25, 50 mg kg^?1 were administered IP, alone then in combinations ranging from 0.03 D:5 M to 0.18 D:30 M mg kg^?1. Analgesia was evaluated using the tail-flick test at time 0 (before injection), 15, 30, 45, 60 and 75 minutes.ResultsMidazolam at all doses administered (5-50 mg kg^?1) did not significantly change tail-flick latencies from baseline values whereas D showed clear dose-dependent increases in tail-flick latency for doses administered in the range of 0.03-0.18 mg kg^?1. Tail-flick latencies in rats administered D + M combinations were significantly greater than D alone (p<0.05).ConclusionsA dose-related analgesic effect was demonstrated for D in the rat, which was enhanced by co-administration of M.Clinical relevanceThe combination of D + M administered IP to rats at doses of 0.12:20 and 0.09:15 mg kg^?1 was shown to be a good combination to provide sedation/analgesia with a duration of action greater than 60 minutes. The onset of sedation was rapid (1-3 minutes), and onset of profound analgesia was reached within 5-10 minutes.  相似文献   

Dynamic cellular uptake of mixed-monolayer protected nanoparticles     

Carney RP  Carney TM  Mueller M  Stellacci F 《Biointerphases》2012,7(1-4):17

Nanoparticles (NPs) are gaining increasing attention for potential application in medicine; consequently, studying their interaction with cells is of central importance. We found that both ligand arrangement and composition on gold nanoparticles play a crucial role in their cellular internalization. In our previous investigation, we showed that 66-34OT nanoparticles coated with stripe-like domains of hydrophobic (octanethiol, OT, 34%) and hydrophilic (11-mercaptoundecane sulfonate, MUS, 66%) ligands permeated through the cellular lipid bilayer via passive diffusion, in addition to endo-/pino-cytosis. Here, we show an analysis of NP internalization by DC2.4, 3T3, and HeLa cells at two temperatures and multiple time points. We study four NPs that differ in their surface structures and ligand compositions and report on their cellular internalization by intracellular fluorescence quantification. Using confocal laser scanning microscopy we have found that all three cell types internalize the 66-34OT NPs more than particles coated only with MUS, or particles coated with a very similar coating but lacking any detectable ligand shell structure, or 'striped' particles but with a different composition (34-66OT) at multiple data points.  相似文献   

Iridovirus-like virions in imported dwarf gourami (Colisa lalia) with systemic amoebiasis     

IG ANDERSON  HC PRIOR  BJ RODWELL  GO HARRIS 《Australian veterinary journal》1993,70(2):66-67

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Acute lymphatic leukemia in a boa constrictor     

F L Frye  J D Carney 《Journal of the American Veterinary Medical Association》1973,163(6):653-654

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Toe grabs     

HC 《Journal of Equine Veterinary Science》1989,9(6):334

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Complete diphallia, imperforate ani (type 2 atresia ani), and an accessory scrotum in a 5-day-old calf.     

Alan T Loynachan  Carney B Jackson  Lenn R Harrison 《Journal of veterinary diagnostic investigation》2006,18(4):408-412

A 5-day-old Angus calf was submitted to the necropsy service at the University of Kentucky Livestock Disease Diagnostic Center. At birth, the calf was noted to have 2 scrota. Five days post-calving the calf developed severe tenesmus and an umbilical infection. Clinical examination revealed atresia ani. At necropsy, complete diphallus, imperforate ani (type 2 atresia ani), and remnants of 2 scrota were identified. This report describes the gross pathologic appearance of a rare case of complete diphallia, imperforate ani (type 2 atresia ani), and an accessory scrotum in a 5-day-old calf.  相似文献   

Biological variation of biochemical analytes determined at 8-week intervals for 1 year in clinically healthy cats     

Stephanie M. Smith  Patrick C. Carney  Jennifer M. Prieto  Meredith L. Miller  John F. Randolph  Giosi Farace  Sarah Peterson  Graham Bilbrough  Mark E. Peterson 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2023,52(1):44-52

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Phase-matched generation of coherent soft X-rays     

A Rundquist  CG Durfee  Z Chang  C Herne  S Backus  MM Murnane  HC Kapteyn 《Science (New York, N.Y.)》1998,280(5368):1412-1415

Phase-matched harmonic conversion of visible laser light into soft x-rays was demonstrated. The recently developed technique of guided-wave frequency conversion was used to upshift light from 800 nanometers to the range from 17 to 32 nanometers. This process increased the coherent x-ray output by factors of 10(2) to 10(3) compared to the non-phase-matched case. This source uses a small-scale (sub-millijoule) high repetition-rate laser and will enable a wide variety of new experimental investigations in linear and nonlinear x-ray science.  相似文献   

Estimates of biological variation in routinely measured biochemical analytes in clinically healthy dogs     

Craig G. Ruaux  Patrick C. Carney  Jan S. Suchodolski  Jörg M. Steiner 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2012,41(4):541-547

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Independent molecular pathways in initiation and loss of hormone responsiveness of breast carcinomas   总被引：4，自引：0，他引：4  

S Sukumar  W P Carney  M Barbacid 《Science (New York, N.Y.)》1988,240(4851):524-526

These studies were set up to determine whether those oncogenes participating in the initiation of mammary carcinogenesis (for example, ras oncogenes) play a direct role in the outcome of events associated with the late stages of tumor development such as loss of hormone dependency. Mammary carcinomas induced by a single carcinogenic insult in pubescent rats was selected as an in vivo model system with direct relevance to human breast cancer. Acquisition of hormone-independent growth in these carcinogen-induced tumors was found to be independent of the activation of ras oncogenes during the early stages of carcinogenesis. In agreement with these observations, introduction of a human ras oncogene into human MCF-7 breast carcinoma cells did not abrogate their hormonal dependency for growth in vivo. These findings suggest that those events responsible for the critical stages of breast cancer development occur independently and in an uncoordinated manner.  相似文献