Aplastic anemia in two kittens following a prescription error     

Paul AL  Shaw SP  Bandt C 《Journal of the American Animal Hospital Association》2008,44(1):25-31

A medication error resulted in two kittens being treated with azathioprine (12 and 12.5 mg/kg) instead of azithromycin for 2 weeks. On clinical examination, the kittens were febrile, weak, and had oronasal hemorrhage. Complete blood cell counts indicated severe bone marrow suppression. Treatment consisted of multiple transfusions, antibiotics, and granulocyte colony-stimulating factor. One of the kittens responded to therapy and had a complete recovery. The other kitten was treated for 40 days with no clinical response before dying. Both kittens also contracted Mycoplasma hemofelis infection from a contaminated blood transfusion.  相似文献   

Analysis of systematic and genetic effects on the prevalence of different types of primary lens opacifications in the wild-boar-colored wirehaired Dachshund     

Müller C  Hamann H  Brahm R  Grussendorf H  Rosenhagen CU  Distl O 《Berliner und Münchener tier?rztliche Wochenschrift》2008,121(7-8):286-291

The aims of this study were to analyze the influence of systematic environmental effects on the prevalence of primary non-congenital cataract (CAT), fibreglass cataract in the nucleus (FCN), and prominent suture lines (PSL) and to estimate the heritabilities of these eye diseases in the wild-boar-colored wirehaired Dachshunds (WWD) bred in the German Dachshund Club 1888 e.V. (DTK). Data included 2,430 WWD born between 1995 and 2003 that were examined between 1996 and 2005 by veterinary ophthalmologists. CAT was diagnosed in 3.83% of the 2,430 dogs, FCN in 3.74%, and PSL in 2.76%. Sex, size, inbreeding coefficient, the age of the dog at examination, experience of the veterinary ophthalmologist and the additive genetic effect of the animal were considered in the multivariate linear model. The age of the dog at examination had a significant influence on the prevalence of FCN. The degree of experience of the veterinary ophthalmologist significantly influenced the prevalence of FCN and PSL. Using a transformation into the Dempster-Lerner threshold model, heritability estimates (h(DL)2) for WWD were h(DL)2 = 0.39 +/- 0.13 for CAT, h(DL)2 = 0.36 +/- 0.11 for FCN and h(DL)2 = 0.49 +/- 0.12 for PSL. Positive genetic correlations (r(g)) were found between CAT and FCN (r(g) = 0.58 +/- 0.21), between PSL and FCN (r(g) = 0.83 +/- 0.23), and between CAT and PSL (r(g) = 0.79 +/- 0.06). The eye diseases investigated here in the Dachshund were found to be genetically influenced and positively correlated traits.  相似文献   

A mixed methods inquiry: How dairy farmers perceive the value(s) of their involvement in an intensive dairy herd health management program     

Erling Kristensen  Carsten Enevoldsen 《Acta veterinaria Scandinavica》2008,50(1):50

Background

Research has been scarce when it comes to the motivational and behavioral sides of farmers'' expectations related to dairy herd health management programs. The objectives of this study were to explore farmers'' expectations related to participation in a health management program by: 1) identifying important ambitions, goals and subjective well-being among farmers, 2) submitting those data to a quantitative analysis thereby characterizing perspective(s) of value added by health management programs among farmers; and 3) to characterize perceptions of farmers'' goals among veterinarians.

Methods

The subject was initially explored by means of literature, interviews and discussions with farmers, herd health management consultants and researchers to provide an understanding (a concourse) of the research entity. The concourse was then broken down into 46 statements. Sixteen Danish dairy farmers and 18 veterinarians associated with one large nationwide veterinary practice were asked to rank the 46 statements that defined the concourse. Next, a principal component analysis was applied to identify correlated statements and thus families of perspectives between respondents. Q-methodology was utilized to represent each of the statements by one row and each respondent by one column in the matrix. A subset of the farmers participated in a series of semi-structured interviews to face validate the concourse and to discuss subjects like animal welfare, veterinarians'' competences as experienced by the farmers and time constraints in the farmers'' everyday life.

Results

Farmers'' views could be described by four families of perspectives: Teamwork, Animal welfare, Knowledge dissemination, and Production. Veterinarians believed that farmers'' primary focus was on production and profit, however, farmers'' valued teamwork and animal welfare more.

Conclusion

The veterinarians in this study appear to focus too much on financial performance and increased production when compared to most of the participating farmers'' expectations. On the other hand veterinarians did not focus enough on the major products, which farmers really wanted to buy, i.e. teamwork and animal welfare. Consequently, disciplines like sociology, economics and marketing may offer new methodological approaches to veterinarians as these disciplines have understood that accounting for individual differences is central to motivate change, i.e. ''know thy customer''.  相似文献   

Colluvisols under cultivation in Schleswig-Holstein. 3. Soil organic matter transformation after translocation     

Lothar Beyer  Hans-Peter Blume  Carsten Kbbemann 《植物养料与土壤学杂志》1999,162(1):61-69

‘Colluvisols’ (Colluvi-cumulic Anthrosols) are an important soil unit in North Germany. In the landscape of loamy till these soils are associated with eroded Luvisols. The soil organic matter (SOM) of top layers of both soils was compared by using approaches of wet chemistry, CPMAS ¹³C-NMR and pyrolysis field-ionization mass spectrometry (Py-FIMS). The Luvisols are sources of SOM transfer due to a continuous erosion process. The annual input of straw and plant residues induces the dominance of litter compounds like proteins, polysaccharides and lignin in the SOM. The Colluvisols are sinks of SOM transfer with a predominance of humic compounds. Lignin is degraded forming humic compounds with an alkylic and aromatic structure. In these soils selected compounds with higher mass signals were detected by Py-FIMS, which may indicate the existence of typical “SOM markers” in the colluvic materials.  相似文献   

Structure-specific detection of plant cuticle bound residues of chlorothalonil by ELISA     

Carsten Jahn  Holger Zorn  Arnd Petersen  Wolfgang Schwack 《Pest management science》1999,55(12):1167-1176

Monoclonal antibodies (mAb) against the main photo-addition products of chlorothalonil with olefinic compounds of plant cuticles were produced. An indirect competitive enzyme-linked immunosorbent assay (ELISA) was developed for the detection of free and bound chlorothalonil and its derivatives. For the characterization of the binding properties of the mAb, derivatives of chlorothalonil (simulating structures of cuticle bound residues) were synthesized. The cross-reactivities of these products were determined by ELISA. The test system was employed to detect bound residues of chlorothalonil in enzymatically isolated tomato cuticles, which had been spiked with methanolic solutions of the compound, irradiated by simulated sunlight and extracted. The use of isolated cuticles allows work to be carried out with authentic material without disturbance by metabolic processes. © 1999 Society of Chemical Industry  相似文献   

Nitrous oxide emissions from grass–clover swards as influenced by sward age and biological nitrogen fixation     

Thorsten Reinsch  Carsten Malisch  Ralf Loges  Friedhelm Taube 《Grass and Forage Science》2020,75(4):372-384

Grassland renovation by cultivation and reseeding has been shown to increase short-term emissions of N₂O, but there is uncertainty about long-term effects, despite the potential impacts of reseeding on sward composition and soil functions. A field experiment was therefore carried out to determine how N₂O emissions from previously renovated grasslands varied in the intermediate to long-term, compared with an undisturbed permanent grassland (PG). Plots on the PG site were renovated, either two (G2) or five (G5) years prior to the two experimental years. In each sward age and experimental year, annual N₂O-measurements were conducted on a weekly basis and compared with the undisturbed PG. Plots were either unfertilized or were fertilized with slurry (240 kg N ha⁻¹ year⁻¹). On average, annual N₂O emissions were 0.39 kg N/ha for the unfertilized swards, and 0.91 kg N/ha for slurry-fertilized swards. Sward age had no effect on N₂O emissions. With increasing sward age the proportion of legumes in the sward was reduced, but a minimum biological nitrogen fixation (BNF) of 88 kg N/ha was maintained even in the fertilized PG. Both sward age and BNF were of limited importance for the annual N₂O emissions compared with the effects of soil carbon content and nitrogen surplus levels. However, measured N₂O emissions were low in all sward age treatments, with a low risk of additional N₂O emissions when BNF is taken into account in fertilizer planning.  相似文献   

Efficacy and Mechanism of Action of Marine Alkaloid 3,10-Dibromofascaplysin in Drug-Resistant Prostate Cancer Cells     

Sergey A. Dyshlovoy  Moritz Kaune  Jessica Hauschild  Malte Kriegs  Konstantin Hoffer  Tobias Busenbender  Polina A. Smirnova  Maxim E. Zhidkov  Ekaterina V. Poverennaya  Su Jung Oh-Hohenhorst  Pavel V. Spirin  Vladimir S. Prassolov  Derya Tilki  Carsten Bokemeyer  Markus Graefen  Gunhild von Amsberg 《Marine drugs》2020,18(12)

Efficacy and mechanism of action of marine alkaloid 3,10-dibromofascaplysin (DBF) were investigated in human prostate cancer (PCa) cells harboring different levels of drug resistance. Anticancer activity was observed across all cell lines examined without signs of cross-resistance to androgen receptor targeting agents (ARTA) or taxane based chemotherapy. Kinome analysis followed by functional investigation identified JNK1/2 to be one of the molecular targets of DBF in 22Rv1 cells. In contrast, no activation of p38 and ERK1/2 MAPKs was observed. Inhibition of the drug-induced JNK1/2 activation or of the basal p38 activity resulted in increased cytotoxicity of DBF, whereas an active ERK1/2 was identified to be important for anticancer activity of the alkaloid. Synergistic effects of DBF were observed in combination with PARP-inhibitor olaparib most likely due to the induction of ROS production by the marine alkaloid. In addition, DBF intensified effects of platinum-based drugs cisplatin and carboplatin, and taxane derivatives docetaxel and cabazitaxel. Finally, DBF inhibited AR-signaling and resensitized AR-V7-positive 22Rv1 prostate cancer cells to enzalutamide, presumably due to AR-V7 down-regulation. These findings propose DBF to be a promising novel drug candidate for the treatment of human PCa regardless of resistance to standard therapy.  相似文献   

几种作物的吸硼特点及模拟   总被引：1，自引：0，他引：1  

华中农业大学学报 《华中农业大学学报》1999

  相似文献   

Modeling the Exchanges of Energy, Water, and Carbon Between Continents and the Atmosphere   总被引：19，自引：0，他引：19  

PJ Sellers  RE Dickinson  DA Randall  AK Betts  FG Hall  JA Berry  GJ Collatz  AS Denning  HA Mooney  CA Nobre  N Sato  CB Field  A Henderson-Sellers 《Science (New York, N.Y.)》1997,275(5299):502-509

Atmospheric general circulation models used for climate simulation and weather forecasting require the fluxes of radiation, heat, water vapor, and momentum across the land-atmosphere interface to be specified. These fluxes are calculated by submodels called land surface parameterizations. Over the last 20 years, these parameterizations have evolved from simple, unrealistic schemes into credible representations of the global soil-vegetation-atmosphere transfer system as advances in plant physiological and hydrological research, advances in satellite data interpretation, and the results of large-scale field experiments have been exploited. Some modern schemes incorporate biogeochemical and ecological knowledge and, when coupled with advanced climate and ocean models, will be capable of modeling the biological and physical responses of the Earth system to global change, for example, increasing atmospheric carbon dioxide.  相似文献   

Circulating Metabolic Hormones During the Peripubertal Period and Their Association with Testicular Development in Bulls     

LFC Brito  AD Barth  NC Rawlings  RE Wilde  DH Crews Jr    PS Mir  JP Kastelic 《Reproduction in domestic animals》2007,42(5):502-508

The objective of the present study was to characterize changes in serum metabolic hormones concentrations from 20 weeks before to 20 weeks post-puberty in bulls and to investigate the associations of metabolic hormones concentrations with testicular development. Leptin concentrations increased from 16 weeks before puberty to 8 weeks post-puberty and insulin concentrations increased from puberty to 8 weeks post-puberty. Growth hormone concentrations decreased after 4 weeks post-puberty, whereas IGF-I concentrations increased from 8 weeks before puberty to 8 weeks post-puberty. During this period, testicular growth was accelerated and testosterone secretion increased substantially, without any significant changes in gonadotropin secretion. Monthly circulating concentrations of leptin, IGF-I and insulin accounted for 63% of the variation in scrotal circumference and 59% of the variation in paired testes volume. In conclusion, the secretion of metabolic hormones was not associated with changes in gonadotropins concentrations. Furthermore, the associations of leptin, IGF-I and insulin concentrations with testes size indicated that these hormones might be involved in a gonadotropin-independent mechanism regulating the testicular development in peripubertal bulls.  相似文献