Comparison of lameness outcomes in horses with acute or chronic digital lameness that underwent magnetic resonance imaging     

DW Koch  MF Barrett  BR Jackman  D MacDonald 《New Zealand veterinary journal》2020,68(5):283-288

ABSTRACT

Aims: To compare the outcome, in terms of lameness score or return to athletic function, of horses with acute vs. chronic digital lameness that underwent magnetic resonance imaging (MRI) of the distal limb and to compare the proportion of horses that received intra-articular therapy of the distal interphalangeal (DIP) joint and pattern of diagnostic analgesia in these groups.

Methods: This is a retrospective study of horses (n?=?95) with acute (≤12 weeks; n?=?46) or chronic (>12 weeks; n?=?49) digital lameness that underwent MRI of the distal limb from 2009–2016, at two equine referral centres in the USA. Criteria for inclusion in the study were that a majority of lameness localised distal to the fetlock, and that lameness assessments for ≥12 months following MRI could be obtained from the medical record or the owner could be interviewed regarding their horse's athletic function. Outcome was characterised by an improvement score where 2?=?return to work at a previous or higher level or lameness improved by one grade or more, 1?=?return to work at a lower level or lameness improved by less than one grade, and 0?=?did not return to work or lameness grade worsened. Whether horses had received intra-articular therapy of the DIP joint and the pattern of diagnostic analgesia prior to MRI was also obtained from medical records or by interviewing the owner.

Results: There was a difference (p?=?0.004) in the proportion of horses assigned to improvement scores of 0, 1 and 2 between horses with acute or chronic lameness. There was no evidence of a difference in the likelihood of having received intra-articular therapy of the DIP joint prior to MRI between horses with chronic or acute lameness (p = 0.085). Similarly, there was no evidence of a difference in the pattern of diagnostic analgesia prior to MRI between the two groups (p = 0.94). Eighty-two percent of owners of horses with acute and 62% of those with horses with chronic lameness had a positive opinion of the utility of MRI as a diagnostic modality.

Conclusion: In a population of horses with digital lameness undergoing MRI, a difference in the outcome, in terms of lameness score or return to athletic function was identified between horses with acute lameness compared to those with chronic lameness.

Clinical relevance: Horses with digital lameness that undergo MRI when the lameness is acute may have an improved prognosis due to accurate diagnosis and earlier application of appropriate therapy.  相似文献   

Saving Genetic Resources of Native Pigs in Occidental and Oriental Countries — Practical Examples of the Characterization and Utilization of Native Pigs in Hungary and Laos     

Jozsef RáTKY  Istvan EGERSZEGI  Peter TOTH  Soukanh KEONUCHAN  Takashi NAGAI  Kazuhiro KIKUCHI  Noboru MANABE  Klaus-Peter BRüSSOW 《The Journal of reproduction and development》2013,59(5):437-441

Worldwide, only a few “fatty” pig breeds exist with different and/or regional utilization. Using the Hungarian Mangalica, which almost went extinct in Europe and the Lao Moo Lat pig, which still has a large population in South-East Asia as exemples, we wanted to demonstrate that indigenous (fatty) pig breeds may represent both national value and tremendous economic potential. Since these less prolific and less productive breeds cannot contribute to mass production, new market roles and methods should be established for them in the premium segment of pork trading. Thus their preservation and propagation needs the comprehensive collaboration of commercial, governmental actors and researchers. Briefly summarizing the history, we report the current results of reproductive physiology research. The commercial renaissance of Mangalica pigs is indebted to the enthusiastic efforts of basic scientists, pig breeding experts and dedicated Mangalica producers. Scientific achievements were applied to practical breeding and production of delicious pork and processed products, which ultimately made the economic success in the Mangalica sector possible. Both, research on and utilization of endangered (pig) breeds maintain not only breed diversities, but also may improve the livelihood of farmers worldwide.  相似文献   

Enhancement of consolidated long-term memory by overexpression of protein kinase Mzeta in the neocortex     

Shema R  Haramati S  Ron S  Hazvi S  Chen A  Sacktor TC  Dudai Y 《Science (New York, N.Y.)》2011,331(6021):1207-1210

Memories are more easily disrupted than improved. Many agents can impair memories during encoding and consolidation. In contrast, the armamentarium of potential memory enhancers is so far rather modest. Moreover, the effect of the latter appears to be limited to enhancing new memories during encoding and the initial period of cellular consolidation, which can last from a few minutes to hours after learning. Here, we report that overexpression in the rat neocortex of the protein kinase C isozyme protein kinase Mζ (PKMζ) enhances long-term memory, whereas a dominant negative PKMζ disrupts memory, even long after memory has been formed.  相似文献   

Rapid erasure of long-term memory associations in the cortex by an inhibitor of PKM zeta     

Shema R  Sacktor TC  Dudai Y 《Science (New York, N.Y.)》2007,317(5840):951-953

Little is known about the neuronal mechanisms that subserve long-term memory persistence in the brain. The components of the remodeled synaptic machinery, and how they sustain the new synaptic or cellwide configuration over time, are yet to be elucidated. In the rat cortex, long-term associative memories vanished rapidly after local application of an inhibitor of the protein kinase C isoform, protein kinase M zeta (PKMzeta). The effect was observed for at least several weeks after encoding and may be irreversible. In the neocortex, which is assumed to be the repository of multiple types of long-term memory, persistence of memory is thus dependent on ongoing activity of a protein kinase long after that memory is considered to have consolidated into a long-term stable form.  相似文献   

Wallowa Russet: A full season long Russet for processing and fresh market     

D. C. Hane  A. R. Mosley  S. R. James  K. A. Rykbost  C. C. Shock  S. L. Love  D. L. Corsini  J. J. Pavek  R. E. Thornton  B. A. Charlton  E. P. Eldredge  S. Yilma 《American Journal of Potato Research》2003,80(4):289-294

The Agricultural Experiment Stations of Oregon, Idaho, and Washington and the U.S. Department of Agriculture jointly released Wallowa Russet in 2002. This late maturing variety is most suitable for frozen french fry use, but may find limited fresh market potential because of outstanding flavor and texture when baked. Wallowa Russet was evaluated as AO87277-6 in Oregon irrigated trials from 1993 through 1999, and in western regional trials from 1997 through 1999. Averaged over 13 locations in seven states, Wallowa Russet produced total yields of 55.6 mt/ha compared to 53.5 and 45.7 mt/ha for Russet Burbank and Russet Norkotah, respectively, and U.S. No.1 yields of 44.4 mt/ha compared to 30.7 and 36.0 mt/ha for Russet Burbank and Russet Norkotah. Specific gravity is consistently higher for Walowa Russet than for Russet Burbank and fry color is as light or lighter; sugar end development is less than that observed in Russet Burbank. Wallowa Russet is similar to Russet Burbank in susceptibility toVerticillium wilt, foliar early blight (Alternaria solani), and potato leafroll virus (PLRV). However, Wallowa Russet develops less net necrosis than Russet Burbank from PLRV infection. Wallowa Russet is more susceptible to common scab (Streptomyces scabies) than Russet Burbank. It has moderate resistance to potato virus Y (PVY). Tubers of Wallowa Russet are less susceptible to tuber infection and decay caused by potato late blight (Phytophthora infestans) than Russet Norkotah and Ranger Russet. Wallowa Russet has less hollow heart, brown center, blackspot bruise, and fewer growth cracks than Russet Burbank but is more susceptible to shatter bruise. Vitamin C is higher for Wallowa Russet (30.4 mg/100 g fresh weight) than for Russet Burbank (21.9) or Russet Norkotah (22.0), and protein content averaged 5.6% compared to 4.7% and 4.9% for Russet Burbank and Russet Norkotah, respectively.  相似文献   

Analgesic management of an eight-year-old Springer Spaniel after amputation of a thoracic limb     

West E  Andreoni V  Keeley B  Self Ia  Jones B 《Irish veterinary journal》2009,62(2):111-118

Analgesic agents were administered perioperatively to an eight-year-old Springer Spaniel undergoing amputation of its right thoracic limb. The amputation was carried out due to a painful, infiltrative and poorly differentiated sarcoma involving the nerves of the brachial plexus. A combination of pre-emptive and multimodal perioperative analgesic strategies was used; including intravenous (IV) infusions of fentanyl, morphine, lidocaine and ketamine.  相似文献   

Gonadal Activity in Male and Female Captive Fossas (Cryptoprocta ferox) During the Mating Season     

BR Vogler  B Blevins  F Goeritz  TB Hildebrandt  M Dehnhard 《Reproduction in domestic animals》2009,44(S2):98-102

The fossa is an endangered, mongoose-like carnivore species endemic to Madagascar with a breeding season (BS) in the southern hemisphere spring. For the present study, faecal samples of captive fossas were collected for over 1 year for five males and four non-pregnant females, and for two pregnant animals during the reproductive period. The goal was to assess gonadal activity using non-invasive hormone measurements of faecal testosterone (T) and gestagen metabolites using assays previously established in our laboratory and further validated in this study. All study animals were housed in northern hemisphere zoos. In males, the seasonal T metabolite profile revealed a peak in spring (March). High performance liquid chromatography (HPLC) analysis was used to characterize the faecal hormone metabolite composition. The highest immunoreactivity was detected in the position of dihydrotestosterone, whereas native T was not detected. In the two pregnant females, gestagen metabolite concentrations increased 4–9 days after the initial matings and remained elevated throughout gestation with concentrations dramatically higher than those of the non-pregnant females during the BS. In these females, gestagen metabolite analyses did not reveal a seasonal pattern similar to the males. The HPLC-analysis revealed that the major proportion of immunoreactivity was associated with an unknown metabolite, whereas native progesterone was undetectable. The seasonal hormone pattern of male fossas gives proof of the reproductive seasonality of this species.
The elevated 5α-pregnan-3β-ol-20-one levels in pregnant animals allows for the characterization of pregnancy in the fossa based on analysis of faecal steroid metabolite concentrations.  相似文献   

Landscape changes as visible indicators in the social,economic and political process of soil erosion: A case study of the municipality of puebla de valles (Guadalajara Province), Spain     

J. D. Garcia Perez  C. Charlton  P. Martin Ruiz 《Land Degradation \u0026amp; Development》1995,6(3):149-161

This paper proposes a methodological approach to data gathering as a sound basis for understanding land degradation processes, breaking down barriers of distrust between Government officials and land users, and promoting participation in planning for soil and water conservation. It examines how landscape changes, of value as indicators of erosion, are perceived by land users and can be used in planning. It is proposed that the participation of land users in the construction of questionnaires, data gathering, analysis and writing up of the findings are examples of the participatory initial stages in planning.  相似文献