Synthesis and in-vitro antifungal activity of 6-trifluoromethyipyrazolo[3,4-6d]pyrimidin-4(5H)-thiones     

Chiara B. Vicentini  Tiziana Poli  Augusto C. Veronese  Vincenzo Brandolini  Maurizio Manfrini  Mario Guarneri  Paolo Giori 《Pest management science》1989,27(1):77-83

Twelve 6-trifluoromethylpyrazolo[3,4-d]pyrimidin-4(5H)-thiones were prepared by the reaction between 4-thiocarbamoyl-5-aminopyrazoles and trifluoroacetic anhydride. They were tested in vitro for antifungal activity against a series of phytopathogenic fungi of different taxonomic classes. The EC50 and MIC values of four compounds were comparable or inferior to those of reference commercial fungicides in controlling Sclerotinia minor, Corticium solani and Phytium ultimum.  相似文献   

Fungitoxicity of 5-aminoisoxazole-4-thiocyanate derivatives     

Chiara B. Vicentini  Vincenzo Brandolini  Tiziana Poli  Mario Guarneri  Paolo Giori 《Pest management science》1992,34(2):127-131

3-Methyl-5-(acyl/alkyl)aminoisoxazole-4-thiocyanates were prepared by rhodanation of N-acyl/alkyl-3-methyl-5-isoxazolamines. These products were tested for antifungal activity against a series of phytopathogenic fungi of different taxonomic classes. Some of the compounds showed interesting in-vitro activity. The more active compound in the in-vitro test displayed a moderate preventive activity against Plasmopara viticola, Alternaria solani and Pyricularia recondita.  相似文献   

Medullary trichomalacia in 6 German shepherd dogs          下载免费PDF全文

Tieghi C  Miller WH  Scott DW  Pasquinelli G 《The Canadian veterinary journal. La revue veterinaire canadienne》2003,44(2):132-136

Medullary trichomalacia is the name proposed for a hair shaft abnormality that was recognized in 6 German shepherd dogs. Affected dogs had multifocal areas of broken hairs, especially on the dorsolateral trunk. Microscopic examination of hair shafts revealed focal areas of loss of architecture, swelling, and apparent softening of the medulla, followed by longitudinal (length-wise) splitting and breakage of the hair shaft. No cause could be found. Affected dogs were otherwise healthy, and apparent spontaneous recovery was the usual outcome. Relapses may occur.  相似文献   

A rapid and simple method for the separation of pure lymphocytes from horse blood     

Zizzadoro C  Belloli C  Badino P  Ormas P 《Veterinary immunology and immunopathology》2002,89(1-2):99-104

A method for the separation of pure and viable lymphocytes and granulocytes from the same blood sample in horses was reported. By centrifuging equine heparinized blood at 100 xg for 10 min at room temperature (r.t.), the resulting supernatant plasma was an almost pure (97.71 +/- 0.30%; n = 15) suspension of highly viable (98.72 +/- 0.28%) lymphocytes. When sodium citrate was used as an anticoagulant, lymphocyte suspensions collected in the same manner showed lower purity (87.89 +/- 1.59%; n = 9) and higher yields (56.56 +/- 3.89%, n = 9 versus 36.11 +/- 2.23%, n = 15). Where needed, a further centrifugation at 250 xg for 3 min (r.t.) of heparinized lymphocyte preparations removed an average of 87.39% (n = 15) contaminating platelets. A suspension of 85.96 +/- 2.20% pure granulocytes (93.23 +/- 1.74% neutrophils; n = 14) with minimal contamination by erythrocytes and high viability (93.11 +/- 1.26%) was obtained by performing a flash red blood cell lysis on the white-greyish layer resulting from the centrifugation of the heparinized blood samples. Among the several methods available, the procedure described herein is easy, rapid, cheap and reproducible.  相似文献   

Canine cutaneous melanocytic tumours: significance of β‐catenin and survivin immunohistochemical expression          下载免费PDF全文

Laura Bongiovanni  Alessandra D'Andrea  Ilaria Porcellato  Andrea Ciccarelli  Daniela Malatesta  Mariarita Romanucci  Leonardo Della Salda  Luca Mechelli  Chiara Brachelente 《Veterinary dermatology》2015,26(4):270-e59

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Nonthymoma‐associated exfoliative dermatitis in 18 cats          下载免费PDF全文

Monika Linek  Silvia Rüfenacht  Chiara Brachelente  Claudia von Tscharner  Claude Favrot  Sylvia Wilhelm  Claudia Nett  Ralf S. Mueller  Ursula Mayer  Monika Welle 《Veterinary dermatology》2015,26(1):40-e13

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Comparison of FEDESI and SCORFAD scoring systems for the evaluation of skin lesions in allergic cats          下载免费PDF全文

Chiara Noli  Tiziana Cena 《Veterinary dermatology》2015,26(6):481-e113

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A case of severe ventricular arrhythmias occurring as a complication of nerve‐stimulator guided brachial plexus location          下载免费PDF全文

Chiara Adami  Nicole Studer 《Veterinary anaesthesia and analgesia》2015,42(2):230-231

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Cardiovascular changes after administration of aerosolized salbutamol in horses: five cases     

Daniela Casoni  Claudia Spadavecchia  Chiara Adami 《Acta veterinaria Scandinavica》2014,56(1):49

Prevention and treatment of intraoperative hypoxemia in horses is difficult and both efficacy and safety of therapeutic maneuvers have to be taken into account. Inhaled salbutamol has been suggested as treatment of hypoxia in horses during general anesthesia, due to safety and ease of the technique. The present report describes the occurrence of clinically relevant unwanted cardiovascular effects (i.e. tachycardia and blood pressure modifications) in 5 horses undergoing general anesthesia in dorsal recumbency after salbutamol inhalation. Balanced anesthesia based on inhalation of isoflurane in oxygen or oxygen and air and continuous rate infusion (CRI) of lidocaine, romifidine, or combination of lidocaine and guaifenesine and ketamine was provided. Supportive measures were necessary to restore normal cardiovascular function in all horses but no long-term adverse effects were noticed in any of the cases.  相似文献   

Ciclosporin‐responsive sterile pustular dermatitides in two dogs     

Silvia Colombo  Chiara Noli 《Veterinary dermatology》2014,25(2):146-147

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