THE COTTON ROOT ROT FUNGUS INDIGENOUS IN ARIZONA DESERTS     

King CJ  Hope C  Eaton ED 《Science (New York, N.Y.)》1932,75(1932):48-49

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Bovine γδ T cells: cells with multiple functions and important roles in immunity     

Guzman E  Price S  Poulsom H  Hope J 《Veterinary immunology and immunopathology》2012,148(1-2):161-167

The γδ T-cell receptor (TCR)-positive lymphocytes are a major circulating lymphocyte population in cattle, especially in young calves. In contrast, human and mice have low levels of circulating γδ TCR(+) T cells (γδ T cells). The majority of the circulating γδ T cells in ruminants express the workshop cluster 1 (WC1) molecule and are of the phenotype WC1(+) CD2(-) CD4(-) CD8(-). WC1 is a 220000 molecular weight glycoprotein with homology to the scavenger receptor cysteine-rich (SRCR) family, closely related to CD163. The existence of 13 members in the bovine WC1 gene family has recently been demonstrated and although murine and human orthologues to WC1 genes exist, functional gene products have not been identified in species other than ruminants and pigs. Highly diverse TCRδ usage has been reported, with expanded variable genes in cattle compared to humans and mice. Differential γ chain usage is evident between populations of bovine γδ T cells, this may have implications for functionality. There is a growing body of evidence that WC1(+) γδ T cells are important in immune responses to mycobacteria and may have important roles in T cell regulation and antigen presentation. In this review, we will summarize recent observations in γδ T cell biology and the importance of γδ T cells in immune responses to mycobacterial infections in cattle.  相似文献   

Natural scrapie in British sheep: breeds, ages and PrP gene polymorphisms.     

N Hunter  J D Foster  J Hope 《The Veterinary record》1992,130(18):389-392

One hundred and sixty-seven sheep of 32 breeds and crossbreeds affected by natural scrapie throughout Britain were tested for the presence of restriction fragment length polymorphisms of the PrP gene observed when their DNA was digested with EcoRI or HindIII. These polymorphisms have already been associated with different susceptibilities to experimental scrapie (controlled by alleles of the Sip gene) in a flock of Cheviot sheep. In two studies 86 to 92 per cent of the sheep were found to carry the PrP gene EcoRI fragment e1 which is associated with high susceptibility (or the sA allele of Sip) to experimental scrapie. The PrP gene HindIII genotypes of the natural scrapie sheep were not apparently associated with differences in susceptibility to scrapie. There was no link between the polymorphisms and the age or breed of the affected sheep.  相似文献   

Role of bovine chemokines produced by dendritic cells in respiratory syncytial virus-induced T cell proliferation     

Werling D  Koss M  Howard CJ  Taylor G  Langhans W  Hope JC 《Veterinary immunology and immunopathology》2002,87(3-4):225-233

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Clinical challenge. An enlarged urinary bladder.     

Katharine Hope  Carlos Sanchez  Suzan Murray 《Journal of zoo and wildlife medicine》2005,36(3):550-552

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Clinical and clinicopathological features and outcomes of cats with suspected dietary induced pancytopenia     

Barbara Glanemann  Karen Humm  Mariana Abreu  Sophie Aspinall  David Buckeridge  Hope Carveth  Hannah Darcy  Jessica Florey  Polly Frowde  Isuru Gajanayake  Kate Green  Emma Holmes  Alenka Hrovat  Anne-Katherine Jasensky  Bryn A Jones  Vasiliki Lantzaki  Eve JY Lo  Kirsty MacDonald  Kevin O'Brien  Alejandro Suárez-Bonnet  Nele Van den Steen  Balazs Szladovits  Annelies Willems  Helen Wilson 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2023,37(1):126-132

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Long‐Term Outcome,Complications and Disease Progression in 23 Dogs After Placement of Tracheal Ring Prostheses for Treatment of Extrathoracic Tracheal Collapse          下载免费PDF全文

Hope K. Chisnell DVM  Anthony D. Pardo MS  DVM  Diplomate ACVS 《Veterinary surgery : VS》2015,44(1):103-113

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Progress in the epidemiology and diagnosis of amitraz resistance in the cattle tick Boophilus microplus     

Jonsson NN  Hope M 《Veterinary parasitology》2007,146(3-4):193-198

Amitraz is a rapidly acting acaricide that has been in use for the control of cattle ticks for more than 30 years. Resistance against amitraz was first reported in Boophilus microplus in Australia in 1980 but has been slow to spread in comparison to resistance against synthetic pyrethroids. The most recent estimate of prevalence of amitraz resistance in Australia is 10.8%. In Mexico, the development and distribution of amitraz appears to have been more rapid and the prevalence has been estimated to be 19.4% in Yucatan state. In New Caledonia, about 10% of properties were confirmed to have amitraz resistance. There is little reliable information on the prevalence of amitraz resistance in southern Africa. Risk factors have been identified, but the small sample sizes in the studies that have attempted to identify risk factors using survey data suggest caution in their interpretation. Regional variation in prevalence has been reported, as has a positive relationship with frequency of acaricide application. There is evidence to suggest that in Australia, amitraz resistance might have emerged on a small number of properties and been disseminated by cattle movements. There is also some evidence to suggest that amitraz resistance can diminish in the field when selection pressure is not applied. The mode of inheritance of amitraz resistance is uncertain and it has been suggested that it is a polygenic trait. The mechanism of amitraz resistance is unknown. Two possibilities have been proposed: octopamine receptor and monoamine oxidase. There is some equivocal support for both possibilities. The larval packet test bioassay is the most reliable method of diagnosing amitraz resistance in B. microplus, and this test has been modified by Miller to provide more accuracy and repeatability. Molecular tests are in development but will not eliminate the need for the bioassay.  相似文献   

The role of dendritic cells in shaping the immune response     

Howard CJ  Charleston B  Stephens SA  Sopp P  Hope JC 《Animal health research reviews / Conference of Research Workers in Animal Diseases》2004,5(2):191-195

Dendritic cells are central to the initiation of primary immune responses. They are the only antigen-presenting cell capable of stimulating naive T cells, and hence they are pivotal in the generation of adaptive immunity. Dendritic cells also interact with and influence the response of cells of the innate immune system. The manner in which dendritic cells influence the responses in cells of both the innate and adaptive immune systems has consequences for the bias of the adaptive response that mediates immunity to infection after vaccination or infection. It also provides an opportunity to intervene and to influence the response, allowing ways of developing appropriate vaccination strategies. Mouse and human studies have identified myeloid, lymphoid and plasmacytoid dendritic cells. Studies in domesticated animals with agents of specific infectious diseases have confirmed the applicability of certain of the generic models developed from mice or from in vitro studies on human cells. In vivo and ex vivo studies in cattle have demonstrated the existence of a number of subpopulations of myeloid dendritic cells. These cells differ in their ability to stimulate T cells and in the cytokines that they produce, observations clearly having important implications for the bias of the T-cell response. Dendritic cells also interact with the innate immune system, inducing responses that potentially bias the subsequent adaptive response.  相似文献   

What is your diagnosis? Panosteitis     

Baird H  Kerwin SC  Henry G  Porterpan B  Johnson MC 《Journal of the American Veterinary Medical Association》2005,226(6):871-872

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