Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds     

TH Morris  SW Paine  PW Zahra  EC Li  SA Colgan  SL Karamatic 《Australian veterinary journal》2020,98(12):578-585

Animals used in sport should be treated as required to ensure animal welfare but any such use of medication should also be controlled to ensure integrity. Pharmacokinetic studies on groups of six greyhounds were performed to measure plasma and urine levels of carprofen and firocoxib to inform medication control advice. Using the standard methodology for medication control the Irrelevant Plasma Concentration was determined as 20 and 2 ng/mL for carprofen and firocoxib, respectively. The Irrelevant Urine Concentration was also determined as 0.3 and 2 ng/mL for carprofen and firocoxib, respectively. These Irrelevant Plasma and Urine Concentrations will allow laboratory Screening Limits, Detection Times and Withdrawal Time advice to be determined and publicised by regulators of greyhound racing. The Screening Limits will also inform Recommended Limits of Detection if meat-containing residues of these medications are fed to greyhounds.  相似文献   

Seasonal variations of chemical constituents in the muscle and viscera of small abalone fed different diets   总被引：1，自引：0，他引：1  

Tze-Kuei Chiou  Meng-Mei Lai and  Chyuan-Yuan Shiau 《Fisheries Science》2001,67(1):146-156

SUMMARY: The seasonal changes in levels of chemical constituents in the muscle and viscera of small abalone Haliotis diversicolor fed gracilar and an artificial diet were investigated. Muscle yields were higher in winter and spring. In October specimens, total adenosine 5'-triphosphate (ATP)-related compounds (ARC), total free amino acids (FAA), and glycogen in both muscle and viscera decreased markedly. The artificial diet fed to small abalone had much higher glycogen in the muscle than those fed on gracilar, and showed a great seasonal change. Total amounts of ARC in the muscles were higher through March to July, while those in the viscera were maximal in January. Taurine, arginine, glycine, glutamic acid, and alanine were the major FAA in both tissues, accounting for 81–94% of the total FAA. Total amounts of FAA in the muscles were higher in the samples collected from winter and early spring than in other seasons. Glycine, glutamic acid, and adenosine monophosphate might be the most important taste components related to the palatability of small abalone. Their total amounts in the muscles of the two specimens were considerably high in December to March. This finding suggested that small abalone produced in winter and early spring might be more palatable.  相似文献   

Resveratrol modulates MED28 (Magicin/EG-1) expression and inhibits epidermal growth factor (EGF)-induced migration in MDA-MB-231 human breast cancer cells     

Lee MF  Pan MH  Chiou YS  Cheng AC  Huang H 《Journal of agricultural and food chemistry》2011,59(21):11853-11861

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Starch characteristics and their influences on in vitro and pig prececal starch digestion     

Lee TT  Huang YF  Chiang CC  Chung TK  Chiou PW  Yu B 《Journal of agricultural and food chemistry》2011,59(13):7353-7359

The main objective of this research was to study the characteristics of starch granules and their influences on in vitro and pig prececal starch digestion of corn, dehulled barley, wheat, and potato. Scanning electron microscopy was used to study the starch endosperm structure in the parent material as well as in vitro starch digestion. The results showed that corn starch granules were polyhedral, with a diameter ranging from 2 to 10 μm, whereas those of dehulled barley and wheat were spherical, with a diameter ranging from 5 to 20 μm. Potato had the largest starch granules among starch sources reported herein, with oval spheres of 10-50 μm in diameter. In vitro starch hydrolysis showed that starch granules of corn degraded faster than the starch of dehulled barley and wheat, with the potato starch being degraded the slowest. The in vivo digestibility trial using ileal-cannulated pigs confirmed the starch degradation of grains. The in vitro (x, %) and in vivo (y, %) digestibility were highly correlated [y = 6.5304x - 538.48 (R(2) = 0.9924)]. On the basis of the results, in vitro starch hydrolysis might be useful in predicting in vivo prececal starch digestibility. The digestion kinetic characteristics of different starch sources might be employed to evaluate the starch digestive rate at the pig ileum.  相似文献   

Shedding pattern and serological profile of porcine circovirus type 2 infection in cesarean-derived, colostrum-deprived and farm-raised pigs     

Chiou MT  Yang CY  Chang TC  Chen C  Lin CF  Ye LJ 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2011,73(4):521-525

Six 5-week-old porcine circovirus type 2 (PCV2)-free, cesarean-derived, colostrums-deprived (CDCD) pigs were inoculated intranasally with 10(6) TCID(50) of PCV2. Four CDCD pigs were untreated cohabitants. Forty farm-raised pigs from two PCV2-contaminated herds were randomly selected for PCV2 trace investigations. Blood, nasal, oropharyngeal and fecal samples were collected from all tested pigs weekly. The PCV2 DNA shed at 6-11 and 7-12 weeks of age for PCV2-inoculated pigs and cohabitants, respectively. All the CDCD pigs exhibited seroconversion after PCV2 exposure. In the farm-raised animals, PCV2 shed at 9-15 weeks of age and seroconversion started at 11 weeks of age. Collectively, the pigs had a prolonged PCV2 shedding period following viral exposure, and growing pigs were the source of horizontal PCV2 transmission in PCV2-infected herds.  相似文献   

Adrenal teratoma in an ox     

PW LADDS  P. RUSSELL†  RA FOSTER 《Australian veterinary journal》1990,67(12):464-465

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Residues of endosulfan in the tissues of lactating goats     

INDRANINGSIH †  CS McSWEENEY‡  PW LADDS 《Australian veterinary journal》1993,70(2):59-62

SUMMARY: The sites of tissue accumulation in lactating goats of the organochlorine insecticide endosulfan were studied. Twelve lactating goats were dosed orally with endosulfan (1 mg/kg body weight per day) for 28 days. Groups of 3 animals were killed on days 1, 8, 15, and 21 after endosulfan treatment ended and their tissues examined for the presence of endosulfan. Total residues of α and β endosulfan and endosulfan sulphate (mg/kg) were detected in kidney (0.29), gastro-intestinal tract (0.20), liver (0.12), brain (0.06), muscle and spleen (0.04), lung and heart (0.01) and milk (0.02) on the flrst sampllng day but within 15 days, concentrations had fallen to < 0.01 mg/kg in all tissues except kidney (0.20). Endosulfan could not be detected in animals 21 days after dosing had ceased. The residue in milk could only be detected on day 1 of sampling. This study indicates that kidney rather than fatty tissue should be used to monitor the presence of endosulfan in animals intended for human consumption.  相似文献   

Detection of Tritrichomonas foetus antigens in formalin-fixed, paraffin embedded sections by the peroxidase antiperoxidase technique     

CM CAMPERO  PW LADDS  RG HIRST  JA VAUGHAN  DE EMERY 《Australian veterinary journal》1989,66(8):264-266

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Disease-husbandry associations in farmed crocodiles in Queensland and the Northern Territory     

GN BUENVIAJE  PW LADDS  L. MELVILLE†  SC MANOLIS‡ 《Australian veterinary journal》1994,71(6):165-173

SUMMARY To investigate husbandry-disease associations in farmed crocodiles 7 farms in Queensland and the Northern Territory were visited and details of past and present farm design and husbandry practices were recorded. In addition pathological examination of 300 (mostly young) crocodiles was carried out (85 necropsied, one biopsied and 214 examined retrospectively). Mortality rate and occurrence of disease, especially opportunistic infections with bacteria and fungi, were highest during winter months and in farms located at greater latitudes. A difference in the presence and prevalence of disease between the initial establishment phase of Northern Territory crocodile farms (1984–87) and currently (1988–91) was apparent; parasitic infections are now relatively infrequent and bacterial septicaemias and mycoses less common as a result of some provision of artificial heating for juveniles. Gross and microscopic changes observed in visceral and periarticular gout, bacterial hepatitis/septicaemia, deep and superficial mycosis, pentastomiasis and other parasitic infections are described.  相似文献   

Efficacy of praziquantel in the treatment of green sea turtles with spontaneous infection of cardiovascular flukes     

W. ADNYANA  PW LADDS  D. BLAIR 《Australian veterinary journal》1997,75(6):405-407

Objective To assess the efficacy of praziquantel as a treatment for cardiovascular flukes in turtles.
Procedure Six green sea turtles ( Chelonia mydas ) spontaneously infected with cardiovascular flukes (Digenea: Spirorchiidae) were treated orally with praziquantel, and necropsied 3 or 7 days later to look for flukes in the heart and major blood vessels. Six similar animals were maintained as untreated controls.
Results Absence of flukes in treated, but not control turtles, indicated that a one day course of treatment at a dose rate of 3 times 50 mg/kg body weight is effective.
Conclusion This result should be of value for preventing disease in wild caught green turtles introduced into farms or aquaria.  相似文献