Multiple colonic enteroliths in an Arabian gelding with chronic intermittent colic     

SA COLGAN  JD WRIGHT  P. GAVEN 《Australian veterinary journal》1997,75(2):100-101

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Vitamin B₁₂ responses to cobalt pellets in beef cows     

GJ JUDSON  JD McFARLANE  A. MITSIOULIS  P. ZVIEDRANS 《Australian veterinary journal》1997,75(9):660-662

Objective To assess the effectiveness of cobalt pellets in maintaining adequate vitamin B₁₂ in beef cows on pasture of low cobalt content.
Design A field experiment in a herd grazing cobalt deficient pasture.
Animals Mature Murray Grey cows.
Procedure Cows were given a single oral dose of 0, 1, 2 or 4 cobalt pellets (30 g pellets containing 30% by weight cobaltic oxide) with a selenium pellet and a grub screw. Samples of blood, liver, faeces and milk for chemical analyses were collected at intervals over a period of 2 years after treatment.
Results A single cobalt pellet raised liver vitamin B₁₂ concentration of cows above that of untreated cows for at least 28 weeks, and 2 or 4 pellets for 57 weeks. Plasma vitamin B₁₂ concentration was an unreliable indicator of the effectiveness of cobalt pellet therapy. Milk vitamin B₁₂ and faecal cobalt concentrations increased in response to cobalt pellet therapy.
Conclusion These studies show that one cobalt pellet will prevent vitamin B₁₂ inadequacy in beef cows for between 28 and 57 weeks; two or four pellets will prevent inadequacy for 57 to 75 weeks. Milk vitamin B₁₂ concentration may be a useful indicator of the effectiveness of cobalt pellets in increasing the vitamin B₁₂ supply in lactating cows.  相似文献   

Hepatotoxicity associated with CCNU (lomustine) chemotherapy in dogs     

Kristal O  Rassnick KM  Gliatto JM  Northrup NC  Chretin JD  Morrison-Collister K  Cotter SM  Moore AS 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2004,18(1):75-80

One hundred seventy-nine tumor-bearing dogs were treated with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) between 1995 and 2001. CCNU was given as a single dose of 50-110 mg/m2 body surface area PO. Treatment interval varied, but the minimal interval between CCNU doses was 3 weeks. After treatment, 11 dogs (6.1%) developed hepatic toxicity. The median number of CCNU doses and the median total cumulative CCNU dose were significantly higher in dogs that developed hepatic toxicity (4 doses; 350 mg/m2) than in dogs without hepatic damage (3 doses; 230 mg/m2). Median duration to detection of hepatic toxicity from the last dose of CCNU was 11 weeks (range 2-49 weeks). Common biochemical abnormalities were abnormally high serum liver enzyme activities and hypoalbuminemia. Six dogs with CCNU-associated hepatic toxicity had ascites, and 3 dogs had concurrent pleural effusion. Serum concentrations of bile acids were abnormally high in 4 of 5 dogs tested. Percutaneous ultrasound-guided liver biopsies were performed in 10 dogs, and findings were nonspecific and chronic in nature. Seven dogs were euthanized because of progressive liver failure, and their median survival from diagnosis of liver disease was 9 weeks. Three dogs died of other causes and 1 dog of unknown cause. Although clinical signs resolved in 3 dogs, biochemical abnormalities and histopathologic lesions persisted 4 to 38 months from the time of diagnosis of liver disease. Our findings suggest that CCNU can cause delayed, cumulative dose-related, chronic hepatotoxicity that is irreversible and can be fatal.  相似文献   

Conservation biology and the preservation of biodiversity in Australia: a role for zoos and the veterinary profession     

JD KELLY  AW ENGLISH 《Australian veterinary journal》1997,75(8):568-574

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The relationship of selected two-dimensional echocardiographic measurements to the racing performance of 5431 yearlings and 2003 two-year-old Thoroughbred racehorses     

Jeffrey A. Seder AB  MBA  JD  Charles E. Vickery III BS  Patrice M. Miller 《Journal of Equine Veterinary Science》2003,23(4):149-167

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The relationship of subsequent racing performance to foreleg flight patterns during racing speed workouts of unraced 2-year-old Thoroughbred racehorses at auctions     

Jeffrey A. Seder AB  MBA  JD  Charles E. Vickery III BS 《Journal of Equine Veterinary Science》2005,25(12):505-522

Workouts of 980 unraced 2-year-old Thoroughbred racehorses at major U.S. auctions were videotaped using digital high-speed video equipment (ie, slow motion) and studied for signs of extraneous foreleg motion.^a Extraneous foreleg motion included, but was not limited to: 1) hyper rotation of the cannon bone on an axis parallel to the plane of the running surface (ie, moving in sagittal plane; hoof hitting an elbow in extreme cases) and perpendicular to the direction of the racetrack longitudinally; and 2) foreleg flight patterns not symmetrical and/or not parallel to the vector of the forward momentum of the horse's center of gravity (eg, winging, paddling, and/or wobbling at joints). Experienced Thorough bred racehorse industry videographers and gait analysis researchers were trained and used as film reviewers who rated foreleg motion on a scale of 1 to 5, with 1 indicating little or no extraneous motion, 3.5 indicating average extraneous motion (relative to the other unraced 2-year-olds at these auctions and to more than 20,000 similar horses at similar auctions over the past 10 years), and 5 indicating extreme extraneous motion (ie, at least 1 standard deviation or more from the mean). Because these were subjective ratings, only the more extreme rankings were used for comparison purposes in this study—that is, a minority (15.3%) of the overall study population.

A group of 73 horses with “good” foreleg motion had ratings from 1 to 3. A group of 77 horses with “bad” foreleg motion had ratings from 4 to 5. The subsequent North American racing performance of horses with good and bad foreleg motion was compared. Both groups had similar average velocity and similar distribution patterns of the velocities of the workouts, so the differences between the groups that are discussed in this study were not caused by different overall workout velocities.

Extraneous foreleg motion was shown to be related to subsequent racing earnings and the level of racing competition achieved. Horses with good foreleg motion (as defined herein) earned more and had greater stakes-level success than horses with bad foreleg motion. For example, the median earnings per start of horses with good foreleg motion was 83% higher than those of horses with bad foreleg motion, and horses with good foreleg motion were 58% more likely to win a top race (ie, one designated as a “graded” stakes) than horses with bad foreleg motion. However, the “good movers” raced less overall than the “bad movers.”

A secondary finding of this study is that although there is a widely held industry belief that horses with high action or bad foreleg motion are more suited to turf racing, horses with good foreleg motion were more likely than horses with bad foreleg motion to race at least once on turf, and, among horses to race on turf, horses with good foreleg motion were more likely than horses with bad foreleg motion to win and to finish “in the money” (ie, at least third).  相似文献   

WHAT IS YOUR DIAGNOSIS?     

KL BOSWARD  S RICH  JD WHITE  P MARTIN  R MALIK 《Australian veterinary journal》2006,84(3):82-82

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Prophylactic trimethoprim-sulfadiazine during chemotherapy in dogs with lymphoma and osteosarcoma: a double-blind, placebo-controlled study     

Chretin JD  Rassnick KM  Shaw NA  Hahn KA  Ogilvie GK  Kristal O  Northrup NC  Moore AS 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(1):141-148

BACKGROUND: The administration of chemotherapy is associated with risk for morbidity. Management of chemotherapy-related morbidity in veterinary oncology has been primarily supportive. HYPOTHESIS: The purpose of this study was to evaluate the effect of prophylactic antimicrobial use on chemotherapy-associated morbidity in dogs with lymphoma or osteosarcoma. ANIMALS: Dogs presenting with histologically confirmed osteosarcoma or lymphoma were eligible. METHODS: Patients were randomized to receive placebo or trimethoprim-sulfadiazine for 14 days after their first doxorubicin chemotherapy. Both owner and clinician were blinded with respect to treatment. Patient assessment included CBC, physical examination and performance, and toxicosis grading on days 7 and 14. Investigated outcomes were hospitalization, suspicion of infection, gastrointestinal toxicity, neutropenia, nonhematologic toxicity, and quality of life. RESULTS: Seventy-three dogs were enrolled; 34 had osteosarcoma, and 39 had lymphoma. Dogs receiving trimethoprim-sulfadiazine (n = 36) had a significantly reduced hospitalization rate (P = .03), nonhematologic toxicity (P = 0.039), grade 2-4 nonhematologic toxicity (P < .0001), grade 2-4 gastrointestinal toxicity (P = .007). and altered performance (P = .015). By group, dogs with osteosarcoma (n = 34) that received the antimicrobial experienced fewer occurrences of nonhematologic toxicity (P = .02) and less severe nonhematologic toxicity (P = .038). Dogs with lymphoma (n = 39) had significant reductions in the occurrence of hospitalization (P = .035), severity of nonhematologic toxicity (P = .036), and alterations of performance (P = .015). CONCLUSIONS: The use of prophylactic trimethoprim-sulfadiazine has benefit in reducing morbidity in dogs with osteosarcoma or lymphoma during the first 14 days after treatment with doxorubicin.  相似文献   

Acquired factor V inhibitors after allogeneic hematopoietic stem cell transplantation in a dog     

Joseph Masciana  Nathan Peterson  John Chretin 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2020,34(5):2096-2100

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Thermal Structure of Jupiter's Upper Atmosphere Derived from the Galileo Probe     

A Seiff  DB Kirk  TCD Knight  LA Young  FS Milos  E Venkatapathy  JD Mihalov  RC Blanchard  RE Young  G Schubert 《Science (New York, N.Y.)》1997,276(5309):102-104

Temperatures in Jupiter's atmosphere derived from Galileo Probe deceleration data increase from 109 kelvin at the 175-millibar level to 900 ± 40 kelvin at 1 nanobar, consistent with Voyager remote sensing data. Wavelike oscillations are present at all levels. Vertical wavelengths are 10 to 25 kilometers in the deep isothermal layer, which extends from 12 to 0.003 millibars. Above the 0.003-millibar level, only 90- to 270- kilometer vertical wavelengths survive, suggesting dissipation of wave energy as the probable source of upper atmosphere heating.  相似文献